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Database: UniProt
Entry: A0A016TIN1_9BILA
LinkDB: A0A016TIN1_9BILA
Original site: A0A016TIN1_9BILA 
ID   A0A016TIN1_9BILA        Unreviewed;       859 AA.
AC   A0A016TIN1;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   15-FEB-2017, entry version 12.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=Acey_s0097.g2969 {ECO:0000313|EMBL:EYC02844.1};
GN   ORFNames=Y032_0097g2969 {ECO:0000313|EMBL:EYC02844.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae;
OC   Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC02844.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EYC02844.1}.
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DR   EMBL; JARK01001433; EYC02844.1; -; Genomic_DNA.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000024635};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    404    429       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    441    462       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    547    565       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    577    604       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    616    636       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    686    705       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    789    813       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       35     69       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   859 AA;  97860 MW;  0A5868BA9C82899F CRC64;
     MSRCQIFLQT DSAYQCVAEL GELGLAQFLD LNEDMNSYQR KFVNEIRRCE EMERKLNFIE
     EEVTKDEVEI KDYDEHIPAP QPKNMTELEA NFEKLEEELL SINSSSKQLI KNHVQLLEMK
     AVLEKVHLLL DESTRRDAAM SISEAARGEA GPFTIGIAND YDKEKREDNE LKFVTGVINR
     KKVISFERFI WRFCRGKVFV RTADIGERTE LFEAKKTDDK AVFILFFSGE QLRSRVQKIC
     NGFHGVIYNC PENTKERAHL LDQINAQVAD MQNVINKTLE YRRKIIFAAS LSVKKWTIML
     LKLKSIFHTL NMFSVDVTHK CLIAECWVPT VDLPLVKQAL RKGTDQAGSP IQAVLNEMET
     HDMPPTHFKL NKFTQGFQNI VDAYGIANYR EVNPAPWSII SFPFLFAVMF GDSGHGIIMF
     LAALAFVVFE NKLISMKIKD EIFNTFFGGR YVVLLMGIFS IYTGLLYNDI YSKSIDIFGS
     SWKNPYPQSL LASMDEHGFN SSQTMDLTWP PEYSFDSNLG PYPFGVDPIW NVAKNKLNFL
     NPMKMKTSII LGISQMAFGL LLSLCNHIHN RSLVDIFFVF VPQCFFLGCI FVYLCVMVVL
     KWIFFYVNPT FIFGRLYPGS NCAPSLLIGL INMFMLKGRD PGFVQHINSP NATASVTIDG
     KNYTYDVYDQ CYLQQWYPGQ VLAEQILLGL AVVSIPIMLF VKPFYVRWLH NRGLPIPGGH
     GHGGGGEEEE FSFGDVMVYQ AIHTIEFALG CISHTASYLR LWALSLAHAQ LSEVLWDMLL
     SIGLDMGGWA GSAAVFILYF FFGVLSVSIL ILMEGLSAFL HALRLHWVEF NSKFYGGTGV
     AFEPFYFTRL IRIAEGLEQ
//
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