ID A0A016TK86_9BILA Unreviewed; 831 AA.
AC A0A016TK86;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=GPI ethanolamine phosphate transferase 3 {ECO:0000256|ARBA:ARBA00020841};
GN Name=Acey_s0096.g2928 {ECO:0000313|EMBL:EYC03086.1};
GN Synonyms=Acey-C27A12.9 {ECO:0000313|EMBL:EYC03086.1};
GN ORFNames=Y032_0096g2928 {ECO:0000313|EMBL:EYC03086.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC03086.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
CC {ECO:0000256|ARBA:ARBA00008695}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC03086.1}.
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DR EMBL; JARK01001432; EYC03086.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016TK86; -.
DR STRING; 53326.A0A016TK86; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16023; GPI_EPT_3; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037675; PIG-O_N.
DR InterPro; IPR039524; PIGO/GPI13.
DR PANTHER; PTHR23071:SF1; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3; 1.
DR PANTHER; PTHR23071; PHOSPHATIDYLINOSITOL GLYCAN; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 410..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 737..758
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 770..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 804..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 831 AA; 92451 MW; 68C9C76CCCA4EF32 CRC64;
MRSKCSDAKL PHSECWMQRQ FRKVVVLLVD ALRYDFMVPL EDDAERSFFR GHMPGVKKLL
KRGAQIGLLL ADPPTTTLQR IKAITTGTLP TFIDAGDNFA PSAHISEDNI FFQARSRHLN
VTFMGDNTWT SLYPNMFTSV YPYDSFDIND LNTVDAAVKE LLHEEVISHS SADLIVAHVL
GVDHCGHKYG PNHIQMANQL RKVDEIILET ANELFSDDLL VVLGDHGMTT TGDHGGDSDD
ETHAGLLVFS PGHKFPALPD GLRQIDLVPT LSLLLGLPIP FSNLGIVIES LFPQNLTEQA
IALNYEQVRR FANTYAAANP SFEISEIIVH DTANPAEQLR TMHRLQASLR AAWTQFDLSL
MRLGVLSFVE TLLFTLSSRQ LSAAQSVVRS GCLLLQLSLI FGGANDSPAV PLLLAVLPLS
TLHSLISIVS GLISTRWTSF PMLFAYLCVF FHSFSFFSNS FVVYEGYVVR FLAQSILLVS
FGEKTLSSMK DRKTAVRATS PLHALLSRCD KWDVGVLFVS LLLLRSEAFF HRCREEEINC
QQFLPLELIT SLSPDALFWR FVVATASIYS LNFFIERILP DVVPNSLRIA RALSWPTHAF
ITFYHLVQLV PHTEVMQKRL HMMGIGLALT VYALSAIAAL ICVCQKDGPN RAIYLCLVHT
ICWPLLLLLG DGLQPSLIAF LIILYGSIHL CNEVVLPPLL SLLIPLGFYL TGHSPTLSTI
PWQAAFVGLP GNFPVRALPA LLILSHISVS AILVPLSLPL HVFASRESLF SLVGCSAIPA
LFSCLAATVL RRHLMVWKIF APRFIYEGVL FIYFLCVANL TLFISRRLRV L
//
