ID A0A016TPM2_9BILA Unreviewed; 454 AA.
AC A0A016TPM2;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=FACT complex subunit {ECO:0000256|RuleBase:RU367052};
GN Name=Acey_s0086.g1959 {ECO:0000313|EMBL:EYC04730.1};
GN ORFNames=Y032_0086g1959 {ECO:0000313|EMBL:EYC04730.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC04730.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|EMBL:EYC04730.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|EMBL:EYC04730.1};
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum reveal infection-specific gene families.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- FUNCTION: Component of the FACT complex, a general chromatin factor
CC that acts to reorganize nucleosomes. The FACT complex is involved in
CC multiple processes that require DNA as a template such as mRNA
CC elongation, DNA replication and DNA repair. During transcription
CC elongation the FACT complex acts as a histone chaperone that both
CC destabilizes and restores nucleosomal structure. It facilitates the
CC passage of RNA polymerase II and transcription by promoting the
CC dissociation of one histone H2A-H2B dimer from the nucleosome, then
CC subsequently promotes the reestablishment of the nucleosome following
CC the passage of RNA polymerase II. {ECO:0000256|RuleBase:RU367052}.
CC -!- SUBUNIT: Component of the FACT complex.
CC {ECO:0000256|RuleBase:RU367052}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367052}.
CC Chromosome {ECO:0000256|RuleBase:RU367052}.
CC -!- SIMILARITY: Belongs to the peptidase M24 family. SPT16 subfamily.
CC {ECO:0000256|RuleBase:RU367052}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC04730.1}.
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DR EMBL; JARK01001422; EYC04729.1; -; Genomic_DNA.
DR EMBL; JARK01001422; EYC04730.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016TPM2; -.
DR STRING; 53326.A0A016TPM2; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0035101; C:FACT complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 2.30.29.150; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR013953; FACT_Spt16.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013719; RTT106/SPT16-like_middle_dom.
DR InterPro; IPR040258; Spt16.
DR InterPro; IPR048969; SPT16_C.
DR PANTHER; PTHR13980; CDC68 RELATED; 1.
DR PANTHER; PTHR13980:SF15; FACT COMPLEX SUBUNIT SPT16; 1.
DR Pfam; PF08512; Rttp106-like_middle; 1.
DR Pfam; PF08644; SPT16; 1.
DR Pfam; PF21091; SPT16_C; 1.
DR SMART; SM01287; Rtt106; 1.
DR SMART; SM01286; SPT16; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU367052};
KW DNA damage {ECO:0000256|RuleBase:RU367052};
KW DNA repair {ECO:0000256|RuleBase:RU367052};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU367052}; Nucleus {ECO:0000256|RuleBase:RU367052};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transcription {ECO:0000256|RuleBase:RU367052};
KW Transcription regulation {ECO:0000256|RuleBase:RU367052}.
FT DOMAIN 3..101
FT /note="FACT complex subunit Spt16"
FT /evidence="ECO:0000259|SMART:SM01286"
FT DOMAIN 218..308
FT /note="Histone chaperone RTT106/FACT complex subunit SPT16-
FT like middle"
FT /evidence="ECO:0000259|SMART:SM01287"
FT REGION 328..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..400
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..454
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 52627 MW; 3D040FF642D14484 CRC64;
MRHVSPYFNS VAIASNVKEH GEAAAPSNNL TTAFRLIKEI QKRFRTEEAE EREKEGAVKQ
DKLILSQAKA NPKLKDLFVR PNIIAKRISG SLEAHINGFR YTSLRGDRID VLYNNIKHAF
FQPCDNEMII LLHFHLKHPV LWGKKKYKDI QFYTEVGEIT TDLGKYHHMQ DRDDVQSEQM
EREMRRKLNQ TFQNFCDKVV KQTNDQFDFD CPFSELGFLG VPHRSSCMLK PTSSCLVNLT
EWPPFIVTLD EVELVHFERV SFQLKNFDMV FIFKDYNRKT QMVQQIPMSS LDGVKEWLNT
SDLRYTEGIQ SLNWPKIMKT ITDDPEEFFE TGGWNFLGAD SDQEDEPEDE SESEEAYSPS
ESESGEDESD EDESEGEATS EDSDEEGSLD SDESEGKDWS DLEEEAARAD KRRDIEESGG
GGDRDRDRKR HHDRERDRKR HHSSKGGPPP KRHK
//
