ID A0A016TZX7_9BILA Unreviewed; 497 AA.
AC A0A016TZX7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Arf-GAP domain-containing protein {ECO:0000259|PROSITE:PS50115};
GN Name=Acey_s0066.g3706 {ECO:0000313|EMBL:EYC08336.1};
GN Synonyms=Acey-F07F6.4 {ECO:0000313|EMBL:EYC08336.1};
GN ORFNames=Y032_0066g3706 {ECO:0000313|EMBL:EYC08336.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC08336.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC08336.1}.
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DR EMBL; JARK01001402; EYC08336.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016TZX7; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd08831; ArfGap_ArfGap2_3_like; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR PANTHER; PTHR45686:SF4; ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H; 1.
DR PANTHER; PTHR45686; ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}; Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 13..132
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 168..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 54419 MW; 4D329C9C18DEA4C7 CRC64;
MGDDSGPSKS ELQNAMRKLR SIPANKLCFD CNARNPTWAT VTYGVFLCID CSATHRNLGV
HLTFVRSTNL DVNWTWLQLR AMQVGGNANA TQFFKQHGCN SNDAQVKYKS RAAQLYKEKL
AQLCVEVQKK YGNTVFIDTA AVAEEHKEED FFAQDFVQAS QSATSLSSEA YISKEDRNDS
NSDLNSEHGP RVDHLDSHAV ATSAPPPSII LKKPIKKAGA SKKSALGAQK VRIDFDDLEQ
RAVEHEKKSA ELGVAAVQPQ QTAAQDEPVA KLSARLAMQD IQKKTLEAKV SSDPQKAAAV
ERLGMGGFGR PRAAHSVAQG VKPIRQADLS KRTVPSLSPT TKDDEWEFVE DRTTKTNDGD
LFTTDFSSKP QTDFFDSWEE QPQKQTSSVG SGLRKPAAPA PTSDVDIQKK FAGAKAISSD
MYFGSNEMDY ETKAALQRFE GQSSLGSADL WGQGSQPQYS QVPEMSDIKD SLRAGASKVA
EKFSSLSTSF SSYMSER
//
