ID A0A016U945_9BILA Unreviewed; 811 AA.
AC A0A016U945;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN Name=Acey_s0052.g2232 {ECO:0000313|EMBL:EYC11118.1};
GN ORFNames=Y032_0052g2232 {ECO:0000313|EMBL:EYC11118.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC11118.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC11118.1}.
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DR EMBL; JARK01001388; EYC11118.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016U945; -.
DR STRING; 53326.A0A016U945; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638:SF10; CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 241..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 603..709
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 811 AA; 93407 MW; 0AFFA9A6DD811978 CRC64;
MSTGVIRYAE HEYDNPIPRV YGVIDFVDFI CSYLVREIYP IQGSYSRLKL SIAIVSIPLP
NPQMSARSPR SSKYVAVSEQ AGTRFGSAPT VSNSTISNPI QSSIKTMESI AMEAMKPTKV
LEHRSSRIDV NQSSTPTEAV DSNTDVEPLG KKSFVGVVKT AMILRNWMMS AQEHEEDRSS
NINDSLVFEP PPREDNVPIL AAPEEIFETE ITGFEIFKAK VAEWSRRLVF FYVSPSGHFC
YYWTCAVSLG LLYNMLAMVI FIFDDVYIGY FYYWLYLNLF FDCIFLLDIL IQSRTTYTFD
GSEVKNVKMT SKNYYRSYRI YLDVLALVPT DFFLIFYSTI SLVRAIRLFK AYRLNDFIDK
TQKRTSFPHG SKIALLMTAC YIIFHWNACV YFLFSLAEGL SEDDTGAFGF SYYKVFDPRF
PTCSVFNDKN CQFQENFTLL DIDDHRPKYM QEMYAFWEGK FVKWDMGNFS REYSMSIYWS
ALTITTCGQQ PYPSSSPQNM LEVIDTLIGV LVFATIIGGV GSVVTQMNED VYEFRQKMDG
IKFYMKYRMV TPAIQERVIS CVTYMHSQHQ LNDEKELLYV LPPRLQGQIA VNLHMETLKK
VELFKQCSAG FLYEVVLRIK QQIYSPNDYL FRAGERAKEM FIVKRGTLRV IDEESSTPAL
TLTDGATFGE LSVILIAGNQ LGDRRAVSLR SEGYSDVYIL NQDDVSAILQ EYPTDRDILI
SNAREMLRSR DLLSEAAVES TDQPLSMLSL EEQLLRMRNQ IGDLDSQLNN MYASFNNLST
DMKRRLTAVE RIFTQNRRQI KLDCMRGKFK F
//