ID A0A016UK14_9BILA Unreviewed; 502 AA.
AC A0A016UK14;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=phosphatidylinositol N-acetylglucosaminyltransferase {ECO:0000256|ARBA:ARBA00012420};
DE EC=2.4.1.198 {ECO:0000256|ARBA:ARBA00012420};
DE AltName: Full=GlcNAc-PI synthesis protein {ECO:0000256|ARBA:ARBA00032160};
GN Name=Acey_s0036.g3190 {ECO:0000313|EMBL:EYC15520.1};
GN Synonyms=Acey-D2085.6 {ECO:0000313|EMBL:EYC15520.1};
GN ORFNames=Y032_0036g3190 {ECO:0000313|EMBL:EYC15520.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC15520.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC15520.1}.
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DR EMBL; JARK01001372; EYC15520.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016UK14; -.
DR STRING; 53326.A0A016UK14; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; IEA:InterPro.
DR GO; GO:0017176; F:phosphatidylinositol N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03796; GT4_PIG-A-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR039507; PIG-A/GPI3.
DR InterPro; IPR013234; PIGA_GPI_anchor_biosynthesis.
DR PANTHER; PTHR45871; N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN; 1.
DR PANTHER; PTHR45871:SF1; PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR Pfam; PF08288; PIGA; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 69..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..140
FT /note="PIGA GPI anchor biosynthesis"
FT /evidence="ECO:0000259|Pfam:PF08288"
FT DOMAIN 199..306
FT /note="Glycosyl transferase family 1"
FT /evidence="ECO:0000259|Pfam:PF00534"
SQ SEQUENCE 502 AA; 56780 MW; B2D6281ADE683AA8 CRC64;
MTASTDKNKE LFSIALVSDF FCPNAGGVET HIYFLAQCLL ELGHKVVVIT HAYGDRRGIR
YLSNGLKVYY LPFLVVYNGC SLATIIGSLP WLRKIFLREQ IQLIHGHATF SSMAHEAMFN
GWLMGIRTVF TDHSLFGFAD ASAILTNTLV LQYSLANVDR VICVSYTSKE NTVLRGKLDP
RKVFTIPNAI ETRLFYPDPE QFYGNPTTII FLGRLVYRKG ADLLCAIIPK VCTRHPNVRF
IVGGDGPKRL ELEEMREKYH LHSRVTLLGT LPHNMVREVL VQGQIFINTS LTEAFCMSIV
EAASCGYELE IFFIKKVSTY LSVLSLHVVS TRVGGVPEVL PADFISLEEP VPELLVDALS
EAIRKREYRL LMDPIEKHEA VSNMYNWPDI AKRTEVVYQD AMREQTPQWR RGLKRYADQG
IGFGILYITV ALINMLFLII LEYFDPASKN PLANDIPRSK PASRGTAETP VDIKSTTYRE
CSVNHRRNFG MRLRSAAKAP LK
//
