ID A0A016UVF9_9BILA Unreviewed; 993 AA.
AC A0A016UVF9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 20-DEC-2017, entry version 12.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN Name=Acey_s0024.g1072 {ECO:0000313|EMBL:EYC19414.1};
GN ORFNames=Y032_0024g1072 {ECO:0000313|EMBL:EYC19414.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Strongylida; Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae;
OC Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC19414.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC ATPase), a multimeric enzyme that catalyzes the translocation of
CC protons across the membranes. Required for assembly and activity
CC of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- CAUTION: The sequence shown here is derived from an
CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC preliminary data. {ECO:0000313|EMBL:EYC19414.1}.
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DR EMBL; JARK01001360; EYC19414.1; -; Genomic_DNA.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629; PTHR11629; 2.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Complete proteome {ECO:0000313|Proteomes:UP000024635};
KW Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 522 546 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 567 585 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 667 689 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 701 725 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 791 813 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 910 930 Helical. {ECO:0000256|RuleBase:RU361189}.
FT COILED 147 167 {ECO:0000256|SAM:Coils}.
FT COILED 193 220 {ECO:0000256|SAM:Coils}.
SQ SEQUENCE 993 AA; 113222 MW; 47FA0BD2DE75CBD8 CRC64;
MMVLVICASK TFHRRGRLAG TWLRLITLLR QIPRHIVEVS SRSGHSQSLC EVPRAVDRSD
LINVSELFPP TTAVYPELES VTTRAYRAPT KPSSSTMGSL YRSEPMKLCE MILVKDAAYD
CVGELGKYGN VQFNDLNANK NIFQRTFVRE VRRCEELERK LRFLERQVAE CVPGIQLQPI
DATTIETPSH FEINHLETAL DELERDFVEL NRNDSHLRKN LNEMREFQYV LRRVDQFFEV
HMEDEAMNKI EAPEHQQDTF SKSITSGGHI SGQNDIPLTP LLNDEKGENA WFVAGVIPLD
KKNTFERVLW RACRRTAFVR ISDITLTLED PVTLAPIVKC VFIVFFKGES LKMIIDKVCD
GFNARQYPCP KTSKERQSAL FETISRIQDL KIVIDSTQKH RFQILEDVAK DLPTWLKKVH
LQKAIYHTLN MFTVDTNGFL AAECWIPENE MDTVHNALQV GLKASGCDVS PILNEMAKQT
SPPTFHRTNK FTSVFQSIVD SYGVASYREI NPAPYTIITF PFLFAVMFGD AAHGLILFLA
GLFFILNEQK ILARRIRGEI FNTFFGGRYI IVLMGLFSIY TGVLYNDAFA KSFNVFGSSW
ANPYNQSEIE SWIQPKVDAR EAKITTVMLD PATAYLKERG PYPFGVDPIW NIAENRLSFL
NSMKMKMSVI IGVLQMTFGV FLSLLNHIFF NSKVDILTNF IPQLVFLSCI FIYLCGQMVV
KWLFFSVEKG IVLGMEYPGS YCAPSLLIGL INMFMLKERP VGYMMENNGT VHHPTCYLNQ
WYPDQALVEK CLLLTAVGCI PIMLIGRPLA AYFEQKKMAG RRKFLNGILG DDSEHLIAID
RYLHEHSLTD AFVHQAIHTI EFVLGCVSHT ASYLRLWALS LAHAQLSEVL WHMVLIPGIS
SEGNVLSTSI ITYVVFFFFA IMSLSILVMM EGLSAFLHAL RLHWVEFQSK FYQGAGHAFR
PYSLQECLET AQHLSEVTEE QSQVSEVTDE VWN
//
