GenomeNet

Database: UniProt
Entry: A0A016UVF9_9BILA
LinkDB: A0A016UVF9_9BILA
Original site: A0A016UVF9_9BILA 
ID   A0A016UVF9_9BILA        Unreviewed;       993 AA.
AC   A0A016UVF9;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   05-OCT-2016, entry version 10.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=Acey_s0024.g1072 {ECO:0000313|EMBL:EYC19414.1};
GN   ORFNames=Y032_0024g1072 {ECO:0000313|EMBL:EYC19414.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae;
OC   Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC19414.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EYC19414.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JARK01001360; EYC19414.1; -; Genomic_DNA.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000024635};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    522    546       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    567    585       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    667    689       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    701    725       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    791    813       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    910    930       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      193    220       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   993 AA;  113222 MW;  47FA0BD2DE75CBD8 CRC64;
     MMVLVICASK TFHRRGRLAG TWLRLITLLR QIPRHIVEVS SRSGHSQSLC EVPRAVDRSD
     LINVSELFPP TTAVYPELES VTTRAYRAPT KPSSSTMGSL YRSEPMKLCE MILVKDAAYD
     CVGELGKYGN VQFNDLNANK NIFQRTFVRE VRRCEELERK LRFLERQVAE CVPGIQLQPI
     DATTIETPSH FEINHLETAL DELERDFVEL NRNDSHLRKN LNEMREFQYV LRRVDQFFEV
     HMEDEAMNKI EAPEHQQDTF SKSITSGGHI SGQNDIPLTP LLNDEKGENA WFVAGVIPLD
     KKNTFERVLW RACRRTAFVR ISDITLTLED PVTLAPIVKC VFIVFFKGES LKMIIDKVCD
     GFNARQYPCP KTSKERQSAL FETISRIQDL KIVIDSTQKH RFQILEDVAK DLPTWLKKVH
     LQKAIYHTLN MFTVDTNGFL AAECWIPENE MDTVHNALQV GLKASGCDVS PILNEMAKQT
     SPPTFHRTNK FTSVFQSIVD SYGVASYREI NPAPYTIITF PFLFAVMFGD AAHGLILFLA
     GLFFILNEQK ILARRIRGEI FNTFFGGRYI IVLMGLFSIY TGVLYNDAFA KSFNVFGSSW
     ANPYNQSEIE SWIQPKVDAR EAKITTVMLD PATAYLKERG PYPFGVDPIW NIAENRLSFL
     NSMKMKMSVI IGVLQMTFGV FLSLLNHIFF NSKVDILTNF IPQLVFLSCI FIYLCGQMVV
     KWLFFSVEKG IVLGMEYPGS YCAPSLLIGL INMFMLKERP VGYMMENNGT VHHPTCYLNQ
     WYPDQALVEK CLLLTAVGCI PIMLIGRPLA AYFEQKKMAG RRKFLNGILG DDSEHLIAID
     RYLHEHSLTD AFVHQAIHTI EFVLGCVSHT ASYLRLWALS LAHAQLSEVL WHMVLIPGIS
     SEGNVLSTSI ITYVVFFFFA IMSLSILVMM EGLSAFLHAL RLHWVEFQSK FYQGAGHAFR
     PYSLQECLET AQHLSEVTEE QSQVSEVTDE VWN
//
DBGET integrated database retrieval system