ID A0A016UW31_9BILA Unreviewed; 992 AA.
AC A0A016UW31;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN Name=Acey_s0024.g1072 {ECO:0000313|EMBL:EYC19415.1};
GN ORFNames=Y032_0024g1072 {ECO:0000313|EMBL:EYC19415.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC19415.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC19415.1}.
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DR EMBL; JARK01001360; EYC19415.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016UW31; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF56; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 4; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 521..545
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 566..584
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 666..688
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 700..724
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 790..812
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 909..929
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 192..219
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 992 AA; 113224 MW; 8EA4458328A14F95 CRC64;
MISKDLLKHI FHRRGRLAGT WLRLITLLRQ IPRHIVEVSS RSGHSQSLCE VPRAVDRSDL
INVSELFPPT TAVYPELESV TTRAYRAPTK PSSSTMGSLY RSEPMKLCEM ILVKDAAYDC
VGELGKYGNV QFNDLNANKN IFQRTFVREV RRCEELERKL RFLERQVAEC VPGIQLQPID
ATTIETPSHF EINHLETALD ELERDFVELN RNDSHLRKNL NEMREFQYVL RRVDQFFEVH
MEDEAMNKIE APEHQQDTFS KSITSGGHIS GQNDIPLTPL LNDEKGENAW FVAGVIPLDK
KNTFERVLWR ACRRTAFVRI SDITLTLEDP VTLAPIVKCV FIVFFKGESL KMIIDKVCDG
FNARQYPCPK TSKERQSALF ETISRIQDLK IVIDSTQKHR FQILEDVAKD LPTWLKKVHL
QKAIYHTLNM FTVDTNGFLA AECWIPENEM DTVHNALQVG LKASGCDVSP ILNEMAKQTS
PPTFHRTNKF TSVFQSIVDS YGVASYREIN PAPYTIITFP FLFAVMFGDA AHGLILFLAG
LFFILNEQKI LARRIRGEIF NTFFGGRYII VLMGLFSIYT GVLYNDAFAK SFNVFGSSWA
NPYNQSEIES WIQPKVDARE AKITTVMLDP ATAYLKERGP YPFGVDPIWN IAENRLSFLN
SMKMKMSVII GVLQMTFGVF LSLLNHIFFN SKVDILTNFI PQLVFLSCIF IYLCGQMVVK
WLFFSVEKGI VLGMEYPGSY CAPSLLIGLI NMFMLKERPV GYMMENNGTV HHPTCYLNQW
YPDQALVEKC LLLTAVGCIP IMLIGRPLAA YFEQKKMAGR RKFLNGILGD DSEHLIAIDR
YLHEHSLTDA FVHQAIHTIE FVLGCVSHTA SYLRLWALSL AHAQLSEVLW HMVLIPGISS
EGNVLSTSII TYVVFFFFAI MSLSILVMME GLSAFLHALR LHWVEFQSKF YQGAGHAFRP
YSLQECLETA QHLSEVTEEQ SQVSEVTDEV WN
//
