ID   A0A016UY20_9BILA        Unreviewed;       751 AA.
AC   A0A016UY20;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Extracellular Endonuclease subunit A domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   Name=Acey_s0023.g781 {ECO:0000313|EMBL:EYC19921.1};
GN   ORFNames=Y032_0023g781 {ECO:0000313|EMBL:EYC19921.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC19921.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC19921.1}.
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DR   EMBL; JARK01001359; EYC19921.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016UY20; -.
DR   STRING; 53326.A0A016UY20; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd16018; Enpp; 1.
DR   Gene3D; 3.30.1360.180; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR   InterPro; IPR044925; His-Me_finger_sf.
DR   InterPro; IPR002591; Phosphodiest/P_Trfase.
DR   PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR   PANTHER; PTHR10151:SF114; ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE C27A7.3; 1.
DR   Pfam; PF01663; Phosphodiest; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   SUPFAM; SSF54060; His-Me finger endonucleases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        28..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   751 AA;  85292 MW;  C0FF47825540BFA8 CRC64;
     MSQSSREAMD TTTTTTTGSS AAKNRAGLLL LVALLPMMVL LVVALGFFLF SFPDTSDDRR
     HEYGKYFSCS CKCNRSDLLE PHPPLVVISF DGYAKKYLSF KSQTVFRRMA KCGVSAEAVY
     SGFPSLTFPN HYTMATGLHP GHSELVHNTI LDPSVHPEPK YLGRNLMDGH YRKEPIWSYY
     KRHWKRKAAT YSWIGSQHNS SYYLQPDYMI PFSSSMTARG TLQQVVNWLR MDPANRPGLI
     MAYITEPDYT GHWTAGPRIT EVVRYLDKVL RKFLQTLEKD GLLCCVNIVF ISDHGMGEIK
     KYVVLDQHFN IKDLTILNGV LTHIFKGNST LTDDQITEAL TCKGTDNVRV FTKSTMPLRL
     HYSKSKRIGD LVLLTKMDTL VVSTKKQIRR DKPGAHGFDY IEPDMHTIMF AQGPSFKQNV
     VLPAFQNVEY MNLWRKLLKI PQMETDGEPA FMDLALNTHD EYLKPPQSIP NIQKCSYSRA
     KALENTCGEC SVEDRISFEN WATCAVGGVS KAVVPQSESP QFRSIVGCND MAIIKTSKEE
     AFMMALFEIY SEDDNDHLLR NKCTFNIIKP SATCDRPTVS AKGTELDFKP LSAYPKRVLA
     NEHSLFSPWK AGFYKDMMTP LNDYTRKIVT KFGKVVSITG TAYDDDYDGK YSPIASNSPY
     PTHLYRILLR CAGKWSNEGA YCANPKDTKV LSFVFPHMDS NANCMNQTEL LLQYTATVKQ
     IETLTNLRFN FTNIPDVQQM ILKMHINVRI W
//