ID A0A016UYN8_9BILA Unreviewed; 840 AA.
AC A0A016UYN8;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=CUB domain-containing protein {ECO:0000259|PROSITE:PS01180};
GN Name=Acey_s0022.g564 {ECO:0000313|EMBL:EYC20310.1};
GN Synonyms=Acey-lev-10 {ECO:0000313|EMBL:EYC20310.1};
GN ORFNames=Y032_0022g564 {ECO:0000313|EMBL:EYC20310.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC20310.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC20310.1}.
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DR EMBL; JARK01001358; EYC20310.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016UYN8; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 5.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 5.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR47537; CUBILIN; 1.
DR PANTHER; PTHR47537:SF2; CUBILIN; 1.
DR Pfam; PF00431; CUB; 5.
DR SMART; SM00042; CUB; 5.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 5.
DR PROSITE; PS01180; CUB; 5.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 745..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..97
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 114..232
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 256..409
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 425..545
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 568..687
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 776..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..793
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 94403 MW; 721955832B404A82 CRC64;
MCVYTFVAGP RQRVKLEFEH FHLAGSSESC EIEYVDIYSE LERVESDLLS ASLGGRYCGT
VSPHVRISLH RVLVLVFHSR AREVDRQFGF RGRYSFIPDT KYQAGTPLNG EDGCDFLIEA
SKRKKGAIFS PTYPGTYPKN FHCSYLLKGR AGQRIRLFFR DFDIYFGGEH CPYDSVTIFD
GPTTSSPIIK KVCGLQQRTE LYSVGTEALI HFNTTNPAKA DPRGFVVEYE FSSRFVDVAQ
LLHGQKGVTH MRGTECDVRV ESNRETTHYI YSPKYPEMYP PNTTCTYILD GLQGDQNLEK
VILTFEEFAV LSDDDSAIVV TDPLSLDDIT CPAAWVGIAI SDATMKATLS STDESNFEST
LCERIPPSSP LRGPYVSTGP RMVVQFGTTD KLITDGLHPS GFKAKVEFKT DFGVTGESIG
TSNECLFRFR SPMGFFNSPR YPANYPLDTN CTYFIEGKPG QQILIHFEQF ALYVGKDEDR
CKDWLEIYDV FQDSGDERLV LQERYCSDTL PGPTVSAFGA YAMRVVFSSD STGSGNGFKA
LYEIRPAAKE DIPSHETKEP RGEGAYRCGR RIRASETTPT GFVMSPNYPV KYNKDVHCDW
EITARDGYKI LLTMVKMEIE GEMSANKAHC QKAVIRVSGA PRPEYCGTNQ NVFTPFVTKN
NSVRISFLTS PDKVNGLKGF NMSWTEVREV NEMSECSSSN EYMCTYSKLC ISSMLRCNGD
ANCGYQDDTD ETHCARKESS TDKTIVIAGV FCGGTFLFIC IFFCYLFKSK LERKKKRQRS
HGSRHRHRQP YRSQKPVGKS IADSELPSPA TSRFVHHDAT GILPPITLHT IADQDQTFYG
//
