ID A0A016UZM2_9BILA Unreviewed; 742 AA.
AC A0A016UZM2;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Type I phosphodiesterase / nucleotide pyrophosphatase {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0023.g779 {ECO:0000313|EMBL:EYC19918.1};
GN ORFNames=Y032_0023g779 {ECO:0000313|EMBL:EYC19918.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC19918.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC19918.1}.
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DR EMBL; JARK01001359; EYC19918.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016UZM2; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd16018; Enpp; 1.
DR Gene3D; 3.30.1360.180; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR10151:SF114; ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE C27A7.3; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 742 AA; 83518 MW; 6666B06D9AF149CA CRC64;
MGVQVIRIGD EQADQKAKDQ SKPNSIGKII VGIIVVLTLL AIIAVIVWLI LQPGKEAENV
KCPRTCRNPR YLSPHPPLVV ISLDGYAHKY LSRKLQPTFD KIAECGVTAE RVYSSFPSLT
FPNHVTISNG LHPGHHGIVA NTIYDPNVSP KPEYLGTTIL DGFYTKEPIW SLYQRQTRRK
AATISWIGSY HNSSYYMQPH HKIPFTPGIH PNEKLDQVFE WLKLDEDKRP GITMIYITEP
DFTGHKTMGP KLNDAIVLVD KAIEKFLAKL KAEGILECVN IVIVSDHGMA EIKNIVVLED
LFSLNDMVIS TGANTLIFRR NSTVTHEEIM SALTCKGTDH TRVFTKETVP LRYHYSPSKR
IGDYVVLGQR DVYTYSEKKD VDPAKTGAHG YDYIQPEMHS IMFARGPSFK EKVVLPPFMN
VEYMNLWTKL LQLPAHENDG DLDFMNIALI SGGGAQIAHH SSIRKCAMNN AIDKHSLDVI
CGQCSPKDKD EFANWAKCEV GGASTAVGVT ADLRDFCYMA GCNDMAVIDV STKNAFLATL
VEIYDQKSND QLLSNDCTFH LAKRSDQCKR PNIAEKVEYR TLSAYPGRVL ANEYSLITPW
KPNFIRDILD PLNDYTKDIV EKLGRVLSIT GTTYDEDYDG KHSASTITSP YPTHLFRILI
ACDGSWSDSG PFCHKPEHTK VLSFVFPHVD GDPNCLTRDK FLLQYTARIK DVESITGQFF
NFTNLPYHQQ VLLKLHTNID LW
//
