ID A0A016V1I0_9BILA Unreviewed; 1003 AA.
AC A0A016V1I0;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Calcium-activated BK potassium channel alpha subunit {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0021.g271 {ECO:0000313|EMBL:EYC20548.1};
GN Synonyms=Acey-slo-2 {ECO:0000313|EMBL:EYC20548.1};
GN ORFNames=Y032_0021g271 {ECO:0000313|EMBL:EYC20548.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC20548.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC20548.1}.
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DR EMBL; JARK01001357; EYC20548.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016V1I0; -.
DR STRING; 53326.A0A016V1I0; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF10; SLOWPOKE 2, ISOFORM D; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 29..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 183..257
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 412..504
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
SQ SEQUENCE 1003 AA; 115598 MW; C34C206753D50962 CRC64;
MQYGVDTSFK SRLQQYFIEN QKSSLRIRLF NVFIKLLSCV LYCVRVVNDS RTLPPFVTPK
ERPEGEIRYE YLIWVDRNDY LWLAQTIVAF ISIAETIIIF YISYQGNIFR LLINVHFLLE
LVTSFPFAIT IFQPKLRQLF VPVFLNCWLA KGSLQAMMND LNRGSFMNQS ALFRQLLLLF
AIMLCLIFTG MCSIEHLQRG GERQFDLFTS FYFVMVTFST VGYGDWYPDT WMSRLCVVSF
ICVALVLLPS QIEALGQTWL ERQKSGGDYG GGWSRNEKHV VVTITHLEVE FIRDFLDEFY
AHPENQRIQV ILLSPAELDT QTRLLLKIPL YHERVHYIRG SALRDEDLER ARLSSAQACF
ILSARHQNKK IVTDEHTILR SWAVKDFAPH VKQYVQIFRA ETKMHIEHAE VLICEDEFKY
SLLANNCICP GISTFITLLM HTSRGEEGKK STEPWHKVYG FHSGNEIYMI RAEDSKFFGD
FIGKSFTYAS FHAHRTYGIG LIGLKTNEPN AKIRLNPGVS HVLQGTDILY YMGLTNEESL
YDFRKDLKDQ RRKANLASTI ANIGTVAIDV PNLEEGIIKK PKIKKRGLLQ KTKATDEVRL
IDVPANGSRR PSIAMVMEGK GDSSSDSEHE DACTRCNGPC IQQKIQRTYP QVRTYIGSSN
TVCHMLKEKR PLCCLQLDKA CEHCPYTSAY EYSWTNKPII LAADRTSSGM YNLIIPLRAY
YRPVHELHPI VLLLELEETA SPNPAFLDAV SYFPGIYWMQ GKISVLDNLL RAGVSRAEHV
VVVKETASLA EEHFADCNTI ITVQKIHRMF PRLRMITELT HASNMRFVQF DANSPYSLAQ
SRFEKKERKR GSHMPFMFRL PFAQGGVFSA NMLDRLLYQA IIKPYVVSLT RLLLGIDQTA
DSGYLTSFTV TSDDLWIQTY GRLYQKLCSS VADIPIGIFR TKNMDSKTVS HDMEEKCKSV
DLLETARERK KDMYNHIRCR MRNMGMSMDD ECEFSRFHKI FNF
//
