ID A0A016V318_9BILA Unreviewed; 405 AA.
AC A0A016V318;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Histidine acid phosphatase {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0020.g227 {ECO:0000313|EMBL:EYC21108.1};
GN Synonyms=Acey-pho-5 {ECO:0000313|EMBL:EYC21108.1};
GN ORFNames=Y032_0020g227 {ECO:0000313|EMBL:EYC21108.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC21108.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000032};
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC21108.1}.
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DR EMBL; JARK01001356; EYC21108.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016V318; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR033379; Acid_Pase_AS.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567:SF110; ACID PHOSPHATASE 1, ISOFORM B; 1.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 405 AA; 46071 MW; 50146086906056EE CRC64;
MAEAWQAPLE ANTTTLVYVQ VAWRHGDRTP ATPVPFSGAD SWSEGLGELT KKGIAQQYRL
GKWLRARYGK FLGDRFDRHE VFVRSSDYNR TLMSAQANMA GLFPPSKSEI WETGLAWQPV
PVHSIPKSID KELYEDIACP TASAEFRKVW KSGVVSKMEL ENEDLILFLR EHSQIPNFQF
YMLWMIYDNL FCMLQHNDTH VWPPWMNSSL FSRVQKLYDA SSRMKYHTEV LRRLRGGPLL
KDVIDRFVAK RNGDLGDRPK LYAYSAHDTT LAAMLSTLGI YPAEFPRYAT AVLLELHSRD
GELVIEVYHK NMTDVDSVYR YSIPGCPDPC TLDALRSTVE KYLPNDWTAE CGLAGPDALN
YMISTAVFAC TTVLLAGFIA LDVTLKRRHR SSFASDPLMV DDDEA
//
