ID A0A016V561_9BILA Unreviewed; 691 AA.
AC A0A016V561;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=Acey_s0017.g3416 {ECO:0000313|EMBL:EYC22550.1};
GN Synonyms=Acey-ksr-1 {ECO:0000313|EMBL:EYC22550.1};
GN ORFNames=Y032_0017g3416 {ECO:0000313|EMBL:EYC22550.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC22550.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC22550.1}.
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DR EMBL; JARK01001353; EYC22550.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016V561; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00029; C1; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR44329:SF253; -; 1.
DR PANTHER; PTHR44329; SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00109; C1; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 144..198
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 406..681
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 75961 MW; 8542663C8B89B38D CRC64;
MSIEDFEGSG QTHPRATQAK HSQTTSGAAC IIEITQGYRA NHSPKLPTVN TVVNALTLGN
HNDRCRLSRS ASGSGGSLAV SVSSFGTAGV AHRAHTLSPP SPIGCGSTQS TPTLGASSRV
VQSTSMQFGV QKSPKPSRLV HAIPHKWTKT TKFRLNSESV CHFCQRPLGF GFLHAWEKCR
SCKWKVHTHC RSRIGDSCGL TPEHLRILFD KLVQQNNGDI WNDPQSAVPM SRSLNEPAFQ
YPDSAMGIGD SSSSTNSSAP STPALPLGLG HVSSPYALAT APSRSSERKF TFPDAVPEVP
DIVLPDMSDS EVRPSGWSSS SADYGEGPSS LSTRHGEGSE GTVIVDSTGS GGTEIGASDG
SIGGRSPVGS QGGHTWDRNR WNMSTIRGPN AQASWNEVSI PFQKIEFDKN AVVRGRFGYV
QRGYHFGDVA IKFLNMDHIE ESRRLDEFKS EVAAHKNTRH DNIVLFLGYC LENDKYGIVM
SYCKGPSLYH LLHEKSEPID VGAALVIATQ ICQGVSYLHQ KKIIHKDLRS KNIFIESKNK
VVITDFGLFS MKRLRHPHRN HTILTPSHWL SYLAPELIRA LSEDWRELPF SESSDVFAFS
TIWFELLTSS FPFAGECPDR IIWMVGNGLK APLYNLNTAA DVKELLLRCW SFMNTNRPSF
SEILASLNAL PRKRLDRSPS FPAIRSYESI F
//