ID   A0A016V9W0_9BILA        Unreviewed;       681 AA.
AC   A0A016V9W0;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   Name=Acey_s0014.g2512 {ECO:0000313|EMBL:EYC24454.1};
GN   ORFNames=Y032_0014g2512 {ECO:0000313|EMBL:EYC24454.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC24454.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC24454.1}.
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DR   EMBL; JARK01001350; EYC24454.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016V9W0; -.
DR   STRING; 53326.A0A016V9W0; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR19446:SF415; REVERSE TRANSCRIPTASE-RELATED PROTEIN; 1.
DR   PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          441..681
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   681 AA;  78423 MW;  D19595B58F1FB961 CRC64;
     MDSLFLQYRN DLYFLSARQE DQVRRHWTDR DEETPLNATF DTGEELFLGT CDSRGVGGVG
     VLVNTNLAMN IDSFEQLTTR IGLLRLRRCG SMPALTVFVA YAPTSSYDED EIEAFYMDWR
     SSTGKTIHSI RSSLATSTPR LALEERLRNF TSFRKPTSLR WTLESPGGEY HNEIDHIIVN
     RRFCLTDVGV VPKFYTGSDH RLLRARFFFS RKGEKAAKYK KRSSKPTINW DLFTTLTGFW
     ADTVVDNIDE EYERLIQHLR DSAKKAEGLR TTKRRPSHET LELIRKRGAA RAAGNNQLTS
     ELARRCREAI KEDLKERRAA VLAEAAEAGR SIRNTRRDFA NRKTKMTALR RPDGTITSSR
     RVMEKVIYDF YSDLFDSHVH LTPCHLREDE YVIPSVLPSE VRHAIKSVKN RTAPGPDRIR
     PEHLKNLPTA LVNTLARLFT RYLSECKVPS QWKTSRIVQL YKKGYPQDIG NYRPICLLSV
     VYKLFTRVIL NRIERTLDEG QPCEQAGFRK GFSTIDHIHT VTRLIEVSRE YKMPLCLTFI
     DLKKAFDTVE TEAVLEALGN QGVPTQYIRI FRELYSNFTT RISPFYEDIT IDVRRGVRQG
     DTVSPKLFTA TLEDVMRRLE WDNMGVRVDG RLLHHLRFAD DIVLITPSIS QAERMLADSD
     DACGKIGLQL NLTKTMFMKN G
//