ID A0A016VDN3_9BILA Unreviewed; 645 AA.
AC A0A016VDN3;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0012.g1707 {ECO:0000313|EMBL:EYC25112.1};
GN Synonyms=Acey-max-2 {ECO:0000313|EMBL:EYC25112.1};
GN ORFNames=Y032_0012g1707 {ECO:0000313|EMBL:EYC25112.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC25112.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC25112.1}.
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DR EMBL; JARK01001348; EYC25112.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016VDN3; -.
DR STRING; 53326.A0A016VDN3; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd06614; STKc_PAK; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF10; SERINE_THREONINE-PROTEIN KINASE MAX-2; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 45..58
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 366..617
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 15..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..236
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 400
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 645 AA; 70599 MW; BBD0493ED6F8DFCE CRC64;
MSTPKEKSKV KVRNFFGRIF SPGTSSEKDR GDSSDDSKPS SSLDISQPYN TVHRIHVGYD
GQKFSGLPDT WMDSLLRDIS EADQKKNPNA VVTALRFYAA SMKEKEKAKF MTTNSVYNAS
DEDSDDVEIQ LNGQVTGHHA PTPASSSING LSNVSGSKIA GLSLSSTEDS MSDRAVPSPA
PAFNHSSNAG APVQAKRKES ATVEGGLDVP NPPPPIHPRS AGRKDAPPPP PPPQRSKTAV
VTEGSQPSGN AQKIPPKVPP KPAHLKASSA CASPPPFVSL TSSDTNSIGH SLSNGSVASN
ISSEVENRSY SDKENATAAI SAEKPKAAPE PEAVRVRSQP KEKMTDGQVL EELRQIVNQG
DPLNKYEIKR QIGLGASGTV YVANCKDTND VVAVKRMAFK TQPKKEMLLT EIKVMKQFRH
PNVVNYIESY LVDADDLWVV MDYLEGGNLT DVVVKTELDE GQIAAVLKEC VKALHFLHSH
SIVHRDIKSD NVLLGMDGQV KLTDMGFCAQ IQPGSKRDTV VGTPYWMSPE ILNKKRYNYK
VDIWSLGIMA LEMIDGEPPY LHETPLKAIY LIAQNGKPEI KRRDQLSPDF LNFLDRCLVV
DPEERADAEE LLRHPFLARA KPLSSLIPYI KAVKELKEKE KLSHK
//
