ID A0A016VDN6_9BILA Unreviewed; 1714 AA.
AC A0A016VDN6;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=U5 small nuclear ribonucleoprotein 200 kDa helicase {ECO:0000256|ARBA:ARBA00034541};
GN Name=Acey_s0012.g1710 {ECO:0000313|EMBL:EYC25117.1};
GN ORFNames=Y032_0012g1710 {ECO:0000313|EMBL:EYC25117.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC25117.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC25117.1}.
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DR EMBL; JARK01001348; EYC25117.1; -; Genomic_DNA.
DR STRING; 53326.A0A016VDN6; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 484..667
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 677..914
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1331..1506
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 218..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1714 AA; 194623 MW; 847A8F301BE857F0 CRC64;
MADELARVQQ YEYRQNSNLV LQVDYNLTDR RGREEPTGEV LPLSDRVLKG MKMGDKYMRT
KAPIQEQKKK RKKKADEEDF RIMSKSVIGD NTELMGSYKP RTQETKQTYE VILAFIQEAI
GDQPRDILCG AADEVLAVLK SDKIREKEKK KEVELLLGSL TDERTAVLIN LARKITDFSM
EDEHKMEMDE LDENEGVNVH FDESDEEQDA VIDEIKNVDE SSSDDEGGEE AEHNEILKGG
GFDEEEAAAK KDALHPRDID AHWIQRSLAK FFNDPIVAQQ KVTEVLGILK DSVDDRECEN
KLVLLLGFDH FDFIRILRQH RHMVLYCTLL KQAQDEERVK IEEEMKSRPE LHHILAQLLE
TDEADIVETE RAKREKTAQR RAAAAAGEEA VAAGQWLAGR KVLDLEDLAF SQGSHLMSNK
RCELPDGSYR KQKKSYEEIH VPALKPRPFA EGEKLIDISE LPKWAQPAFD GFKSLNRIQS
RLCESALNSD EHLLLCAPTG AGKTNVALLT VLHEIGKHLN DDGTVKVDEF KCIYIAPMKS
LVQEMVGNFT KRLAPFGITV GEMTGDAQMS KEQFMATQVI VCTPEKYDIV SRKGGERAYS
QLVRLVIIDE IHLLHDDRGP VLEAIVVRTL RQVEQTHDDC RLVGLSATLP NYQDVATFLR
VKPEHLYYFD NSYRPVPLEQ QYIGVTEKKA LKRFQAMNEV VYDKIMEHAG KSQVLIFVHS
RKETAKTAKA IRDACLEKDT LSAFMREGSA STEILRTEAE QVKNHDLKDL LPYGFAIHHA
GMNRLDRTLV EDLFADKHIQ VLFSTATLAW GVNLPAHTVI IKGTQIYNPE KGRWTELGAL
DVMQMLGRAG RPQYDSKGKG ILITNHSELQ FYLSLMNQQL PVESQMIARL PDMLNAEVVL
GSISSVSDAM SWLGYTYLYI RMLKSPTLYG IPIDQAKADP LLEQRRADLI HTACLQLDKG
NLVKYDKKSG LIQATELGRI ASHYYCTFES MQTYNQLLKP TSTEIDLFRI FSLSSEFKNI
AVREEEKLEL QKLAEHVPIP IKESLDESSA KTNVLLQAYI SQLKLDGFAL QSDMVFIAQS
AGRLFRALYE IVLWRGWAAL ALKVLSLCKM VTARQWQSLN PLHQFKKIPT EIVRSIDKRN
YSFERLYDLD QHQLGELIRM PKMGKPLYKF IRQFPKLEMT TLIQPITRTT LRIELTITPD
FQWDEKVHGS AEGFWIFVED VDGELILHHE YFLLKQKFCT EEHVVKMFVP VFDPLPPLYF
VRIVSDRWLG SETVLPISFR HLVLPEKYPP PTELLDLQPL PISALNNKHF EAVFQTKDIK
IFNPIQTQVF RTVYESNDNV LIAAPNGSGK TACAELAILR HFDNNPDAKC VYVTPMEDMA
VKVHNDWQDR LGVALDRTVV LLTGEPSTDL KLLQRGKLII ATPERWDNVS RRWKQRKNVQ
AVKLFVVDDL HMIGGTIGPV LEVICSRMRY MSAQLDTTVR IVGLSSSLTN ARDVGAWLGC
SAAATFNFLP NTRPVPLELY IQGFNLSHTA SRLAAMVRPV YQAISRHAGK LNPKPALVFV
PGRRQSRSTA IDMLTMAHAD GAPQRFLHIS ETDGTFVKLL NSLQDQTLRE TLLCGVGFLH
EGTHAKDFQI VERLFSSGAI QVCIVPRTMC YQISMSAYLV VIMDTQFYNG KYHVYEDYPI
GDVLHMVGLA NRPGRDVDVS TGSWAGVAPN LYYS
//
