ID A0A016VFK1_9BILA Unreviewed; 640 AA.
AC A0A016VFK1;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=FERM domain-containing protein {ECO:0000259|PROSITE:PS50057};
GN Name=Acey_s0011.g1400 {ECO:0000313|EMBL:EYC25817.1};
GN Synonyms=Acey-nfm-1 {ECO:0000313|EMBL:EYC25817.1};
GN ORFNames=Y032_0011g1400 {ECO:0000313|EMBL:EYC25817.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC25817.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell projection, rhabdomere
CC {ECO:0000256|ARBA:ARBA00043944}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC25817.1}.
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DR EMBL; JARK01001347; EYC25817.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016VFK1; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13194; FERM_C_ERM; 1.
DR CDD; cd17097; FERM_F1_ERM_like; 1.
DR Gene3D; 1.20.5.450; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.10.360.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR011174; ERM.
DR InterPro; IPR011259; ERM_C_dom.
DR InterPro; IPR041789; ERM_FERM_C.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR008954; Moesin_tail_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23281; MERLIN/MOESIN/EZRIN/RADIXIN; 1.
DR PANTHER; PTHR23281:SF39; MOESIN_EZRIN_RADIXIN HOMOLOG 2; 1.
DR Pfam; PF00769; ERM_C; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF48678; Moesin tail domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 36..324
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT COILED 335..435
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 575..602
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 640 AA; 74102 MW; 8745E25C824324F7 CRC64;
MRVRTIKHLF IYVSDQISVV IMGLFPFLAR GSGKVVHAKV TTMDADLDRI VIETSWTGRH
LFDAVCRIIG LREVWFFGLQ FTNKKGLPCW LQMDREIRKQ DVPRGEDGCM QFLFLVKFYP
EDVEDELIQD LTRHLFFLQI KQAILSMDLY CSPEASVLLA SFAVQAINGD CTDDIGPLDL
DKLLPKSVIE QYDMSADMWR ERIKRWWINN QGQTREDAEM EYLRVAQDLE MYGILYYPIC
NKKETDLHLG ISAQGLGIYK GSNRITPRPF FSWSEIKNIS FKNKKFHMKT VDKSTISFRA
QERTINPSIL DLCIGTHNLY LRRRQPDTLE VQQMKALAKE DRARRQQEAA RLAREREERL
QVENERNQLK AEIEKIAEQL AQAKEAARKT EETAELLAEK ARASEQETLL LTKRVSEAEA
ECHRLQMNHV KSEEALMRME RKAREAELYA QRISMSLADV NSKPHYASHA LITEPTIWPL
SNLALQGTLS HHQLMISGGS QEGDRASLAE RQQMHQGQLP GVPPPAAPIY RAMPPNVAQM
MHAPPPPDPS VNQRLEFHNL RSELEKSRHD FSEKARLFKE RLNDFRNEID ALKREDRQTE
HDVIHAHNVH NGFDKFTTLR MHKSKSASSL ESFYELESWH
//
