ID   A0A016VPH0_9BILA        Unreviewed;       496 AA.
AC   A0A016VPH0;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   Name=Acey_s0006.g2991 {ECO:0000313|EMBL:EYC29469.1};
GN   ORFNames=Y032_0006g2991 {ECO:0000313|EMBL:EYC29469.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC29469.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC29469.1}.
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DR   EMBL; JARK01001342; EYC29469.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016VPH0; -.
DR   STRING; 53326.A0A016VPH0; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR46238; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46238:SF8; RIBONUCLEASE H; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..496
FT                   /note="Reverse transcriptase domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5001490376"
FT   DOMAIN          80..338
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   496 AA;  56689 MW;  FE83B9F89862B663 CRC64;
     MVFMCLLLEK FHTVTATSKL FTSLVVLEAY IRNHNSNTSL LPHGGPFKPG KATGPDDVAA
     ELWKSRHWNS AQWLTAFLNK IVEEKKTPVD WQRSTTVPIW KRKGNPAECA NYRPIRLLSH
     NMKVFERIID RRIRDIIRVS RNQCGFVANC GTTDAIHAAR LLMEKHSEKQ KPLHLAFLDL
     EKAFDRVPHE AIWYALRWHG VPEELIEWVR ILYADPRSRV QAAAGTSAEF PISVGVHQGS
     ALSPLLFILV MDAITRDLQR PAPWTLLYAD DVMLASEQKE DLQRQTQAWS ERLARFGLRL
     NVKKTEYMTT NPDELSTIHV DGNDLRRTDY FKYLGSTLSA DGNLAHEVVA RVNATWLKWR
     SMTGVLCDKN IPDRFKSKVY RAVVRSVALY GAECWPATKE VERRLSVMET KMLRWTAGVT
     RADRIRNEKI RERFGIAPIA DKLRETRLRW YGHVLRANED TICKVGLDLE VPGKRRKASV
     RAVCQATVAS VQATVA
//