ID A0A016VV22_9BILA Unreviewed; 973 AA.
AC A0A016VV22;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=Acey_s0004.g2059 {ECO:0000313|EMBL:EYC31260.1};
GN ORFNames=Y032_0004g2059 {ECO:0000313|EMBL:EYC31260.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC31260.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC31260.1}.
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DR EMBL; JARK01001340; EYC31260.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016VV22; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15934; 7tmC_mGluRs_group2_3; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF171; G_PROTEIN_RECEP_F3_4 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..973
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001491168"
FT TRANSMEM 560..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 670..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 718..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 749..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 561..823
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 847..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 973 AA; 108536 MW; 542C56AC2ECDFC10 CRC64;
MGWGTILLFL YCIIPLVDAV RQVTVPGEIV LGGLFPIHEA GRNGSQCGKI KADQGVQRMV
AMLYALEKVN QDNSLLPQAS LGAQILDTCS VDSHALEQSL EFIKSVMSSG DGAICADGSP
ASYHRQPVAA VVGAAGSQVS VMVASMLQLF RIPQVSYSST GAELSEKPRF GYFSRVVPPD
NLQAQVMARV VRELDWTYVH AIADTGSYGE RGMDSFRAAA TELGICIDGD VHKISRRWTD
KNFRDLLIRM HRTRKARGVV MFVDEDNLKR LLHTLDKLIK EGHKELERHF WFVASDSWGI
KQSVVLGLEH LLAGAITIAP YVREEKAYIT FFRKLSPAGF TFLEEYWEAL GCGKNYELKY
FGECFDYINY TLKQESYVPF VVDAVRVLAR AISKYITDEC GDTEFHRCSL STSRFLGDRL
QKYYRNVSLS ENEPPLIDAN GDGIGRYDVF QLDSKGVYHK VGKWRSSEDS FEVRVEQVRR
GFRLAAGESP FSVCSTDCPR GHYRAYQDQT CCWACIPCDT ATSIIINVTK CDMCPEGEVP
DETQSYCVPI PPVSMRWDSA WALIPAGFSL LGLSSTVFVV GVFLKFSNTP VIMASGRELC
YCMISGISMC YLLTFFLVSQ PSVPTCAFTR VLMGLSMSAI YAAIITKTNR LARVFKPDSA
QRPRFITPRA QVGICACIVS VQLFGSIIWL LVDPPGTKVV FPSRTEAVLT CKATASHLLV
SLLYNLVLIV ACTVYAFKTR KIPENFNETR HIGFTMYSTC ILWLSFGPIY FATQNNFRIQ
ITSLCMCISL SGTVALVCFF APKIYIVLFQ PYKNVRTRQS AVGRLVNQQM RFMSQLTCNQ
DSYTSAYKPM STASNPSYRP GSEENSHGST QASTIHPLPL PIQDKLSNNN ICLPKTEIGK
KFSLPEEPDH NCPDLLTTND IRRRRPASLY ATMPDVVRPL PLPLKLPPEM NECDSQVALI
LEEIATDPHV TFL
//