ID A0A016W2J3_9BILA Unreviewed; 1163 AA.
AC A0A016W2J3;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=RhoGEF domain protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0001.g11 {ECO:0000313|EMBL:EYC33821.1};
GN Synonyms=Acey-tag-218 {ECO:0000313|EMBL:EYC33821.1};
GN ORFNames=Y032_0001g11 {ECO:0000313|EMBL:EYC33821.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC33821.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC33821.1}.
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DR EMBL; JARK01001337; EYC33821.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016W2J3; -.
DR STRING; 53326.A0A016W2J3; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11793; SH3_ephexin1_like; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845:SF5; EPHEXIN, ISOFORM D; 1.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 686..876
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 911..1034
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1045..1106
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 24..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..224
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1163 AA; 130716 MW; 2FAE3FDE6C14B508 CRC64;
MSMVQEPGLS GAADVRGGSR VRALAHRFET GDTSGAAAAP RAKSDDEVVK ERGSEQEMLL
VVHVDVAGAA AAAAARKTTD QPARARLSRS RASQKKRPQS SSDPLQTSHR QPYAMRKCGS
AHSNLCTVQP VEIKPRVRRE KPPPPQKPVD LAQRAMTWSK CSQPGPSSKR SPLPERESST
PREQTNGNAT EVAEVPTVSS TPSTSRNSRP RLAPPPPPPP KKPARLISRD QTSENKPRLY
REISSSSLNV ETISDSIYQQ LPSPEEALPR SPRLPSSAVP DERPRPSVPT IPLPLPPQSH
EDPDDDDYEC YEQIDYSSDT LTIDGSVVDC SAESSVTYKA SGSEPTTARD RRSETFAESQ
SWNTSSYPRH SLSLPGNSSM CPILDRPQTA ATVRKKPPSP RSAGASELEK LFRLKSSLQQ
NISKKVDQLR QKVGERRIRT SQSVESRDID YSTRGDVTAV SESGSNYKNT DDDIYVYGDE
WSSEDDDDQN VYEDRRSSMY KELEQQLNRA FPVAKMESEY EYDSADFVAS DEGQPRPEAL
PFAALSVTTG SSTDEPSPEE EDYARQYTSR LPTDQPLYQI YMLAEHDKLF DSVLLRSSDS
ACGQEEHAME STGTVDLFRR ESCASSDSGR GADCSTSASA LTSNTSMRRE RLIATSHFGS
QRSLWCELEE VRAAGLLNTL DDETKMRQEA YFEVITSEAS YLRSLNILIT HFMASQELMG
SKSSFSVISN SDRKQLFSNI FAVRDCSERL LSDLETRLEH SLVLDDLCGI LLHHFETNFD
VYIKYCSNQV YQERTLRRLK AENPAFLTAI SRMEADKQCQ GLDMRSFLML PMQRVTRYPL
LVYAILDRLK RGCDEYEVAT KALHAANRVV GECNEGARRM ERTEQLLEVD SRLVYKDPDL
KKIALVSNCR YLVKRGSLVQ LMERKNRNIL QGKQKTRNVY IFLFSDIILV TKKKLNGTYE
CKDYAARRYI DVQPLEVDPN RTTNGAISSL TTRPHLFLCV FMRNARGRQT ELLLNAESET
DRERWLSALR PPISANPEEK IYAEWDCPQA VAVHTYNKNQ DDELSLEVGD MVNILRKMPD
GWFFGEKTSD GQSGWFPSSY VQQILNDHVR ANNYRKRLRL IQAAGSVSTR ESPPRSSATP
LMDRLRRMSN PRFLFQADPT SAL
//
