ID   A0A016WA68_9BILA        Unreviewed;       807 AA.
AC   A0A016WA68;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
DE   Flags: Fragment;
GN   Name=Acey_s0928.g3081 {ECO:0000313|EMBL:EYC36162.1};
GN   ORFNames=Y032_0928g3081 {ECO:0000313|EMBL:EYC36162.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC36162.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC36162.1}.
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DR   EMBL; JARK01000528; EYC36162.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016WA68; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05471; pepsin_like; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR041577; RT_RNaseH_2.
DR   PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR   Pfam; PF00026; Asp; 1.
DR   Pfam; PF17919; RT_RNaseH_2; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..807
FT                   /note="Peptidase A1 domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5009738594"
FT   DOMAIN          75..495
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   REGION          597..621
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        597..615
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         807
FT                   /evidence="ECO:0000313|EMBL:EYC36162.1"
SQ   SEQUENCE   807 AA;  92333 MW;  083EF8B3F250C10B CRC64;
     MLLWLVLLVA ANHAMGERYQ IPLSKIQSKM VQMLRAGSWA THVKEMRAKN HNIMDAPVKK
     SNSNQNINTY HDMEYIANIT IGNPEQTFTV VLDTGSPDTW VVDYTCSADK PLVCDDSICD
     QGLICKVFCP HRVCCEKKSP RKRNPCRGKH YFESAKSSTY VSMNGTWTMG YRPWGKAKGF
     FGNDTLRFGD KGTKQLVVPA TKIGFANGID EYLGERRLDG VVGLAFSSLS YNDAVSPFER
     AWELGLVEPK FTVYMERVGW DAENVFGGMV TYGGLDTQHC GDVIAYEPVS VATYWKFKMD
     PQAMMTMSRE MMREERKEMM EMFFKHLAVQ GQGSATSEVA SVPGVMSALS NRIEKFVFDP
     DMDMGFTKWY TRYKEVFIED AKQLTESARV RLLCEKLDSE TFERYQRHVL PKEVTSIGFE
     ETVATLKQLF DVKTSEFTLR YQGLNLEKSD AEDYLVYTGR VNEFCERARI RELDSDGIKC
     LLWIFGLKSQ REAEIRQRLI AVLDREYKAG RKLSLQELYR ECENFLSLKK DSETIAGNVK
     TVEAAVKEDR RKRECWNCCG DHFAQQCKSK PWFCKQCKKT GHKERFCEVA NRRKAAENGS
     EGRRSRQNSD NRRKKKIMQS SRKHVRGVKI ANATAERIAE YGFKVRLEKC SFAKPEIRYL
     GFIVDKNGRR PNPEKIEAIK SMVEPKNVGQ LRAFLGMITY YAAFMPTMKD LRGPLDALLK
     KDVKWEWTSK QQLAFEKLKK ALSSELNLAH YDPRQKIVVA ADACDYGIGC VISHRYKDGS
     EKPIAHASRS LTAAEKNYSQ IEKEALG
//