ID   A0A016WCN5_9BILA        Unreviewed;       787 AA.
AC   A0A016WCN5;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Peptidase, S9A/B/C family, catalytic domain protein {ECO:0008006|Google:ProtNLM};
GN   Name=Acey_s0794.g2388 {ECO:0000313|EMBL:EYC37400.1};
GN   Synonyms=Acey-dpf-2 {ECO:0000313|EMBL:EYC37400.1};
GN   ORFNames=Y032_0794g2388 {ECO:0000313|EMBL:EYC37400.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC37400.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC       pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC37400.1}.
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DR   EMBL; JARK01000394; EYC37400.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016WCN5; -.
DR   STRING; 53326.A0A016WCN5; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF200; DIPEPTIDYL PEPTIDASE FAMILY MEMBER 2; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          113..499
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          587..779
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   REGION          16..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   787 AA;  88817 MW;  270BB252CD02183D CRC64;
     MESCWNSSVY EGSASVNLNG SATQTPSDDS ENRTASRLQF RRRPTYRKFT FEDLFSGKVF
     LKDSYTTGWT RNGGLIQTKD EFLGGTTVAT VIHPGTFDAV DYLSDSTLMH SLSSNEKYAF
     VSKNIKQIFR HSNEELFEIS RMINGTPSER TFPVGPKGDG LETILTFEWN PNINKNDFVF
     VHEYNIYYQL DPEKPGTVRQ LTDDGGYLLR YGVPDWLYEE EILSSGTAIW WSESGQHIAY
     IRFDDRSVNR IYIPKYTKGS QYPQYEEIPY PKAGVEENPL VRLYIWTVKT NRTVIAEPPA
     DLTRTNQSYY IFSNTWLAMP ANLRHSLGEE RLFTAWATRE QNLVYITLCN EIDCVLTHVQ
     SFTVNGRSMW AEPADFKNVF ASKSGFFLLL PHAYNDGNIY NHIAHMQIQK NGSGQITAWH
     GGAYDIREIK GYDMTSDTLT FISAGGGLGT MRLYKVSQAT SANKSNIVAL SSFLPDCDYG
     THEVSPNGKR AVMSCIKPFQ NTKMYIMDVE KPSSNKLLEG AEEAHIPFDL PELSYEIVKL
     PSGYEVHIGI MKPPKFDPTL KYPLLVDVYG GPNSCKVRQS TPNPNMIHFC STLGAVVAWI
     DGRGSSNRGW NLKAPVYKAL GQFETIDTID AVKYLTEKYS FIEKEQVAVF GWSYGGFLST
     HVAMRDQGET FKCAVAVAPV VDFMLYDSAY TERYLGIPLE NPAGYNASQL LNKASLLENV
     KYLLAHGEAD DNVHFQNSAL LAETLQGELV HFTQLVYSNQ DHSMGSRQAH LFMEIGRFLS
     EECFSED
//