ID A0A016WEQ4_9BILA Unreviewed; 551 AA.
AC A0A016WEQ4;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=PX domain protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0745.g1999 {ECO:0000313|EMBL:EYC38056.1};
GN Synonyms=Acey-F25H2.2 {ECO:0000313|EMBL:EYC38056.1};
GN ORFNames=Y032_0745g1999 {ECO:0000313|EMBL:EYC38056.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC38056.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC38056.1}.
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DR EMBL; JARK01000345; EYC38056.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WEQ4; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProt.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd06886; PX_SNX27; 1.
DR Gene3D; 1.20.80.60; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR037831; SNX17/27/31-like.
DR InterPro; IPR037833; SNX27_PX.
DR PANTHER; PTHR12431; SORTING NEXIN 17 AND 27; 1.
DR PANTHER; PTHR12431:SF19; SORTING NEXIN-27; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 35..128
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 153..261
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 261..363
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 62654 MW; 01CD4197FD16DA1B CRC64;
MYDDSDESSD DNRPSAHSSS SSSRKRLPFD PKPHLVTIVK TNTGFGFNVK GQVSEGGQLR
SLNGQLYAPL QHVSAVLADG AAERANLRRG DRILQVNGVN VEGATHRHVV DLIKHGGDRL
TMIVISVEDS DVDRFECCEE SVISYRHDYS ESRSLPVTIP SYHTVNDGVE KFVVFNLYMA
GRHLGSRRYS EFVELHQLLR REFIDYSFPK LPGKWPFSLS EQQLDSRRRG LELYLERVCS
VKVIADSDIM QDFLMECDPS CEVEVRVLLP DGGHACVNIR RNSSTSLLFA LLARKLNMSR
DMALSCAIFE TMEQSFALSC LLIQTIACVT ERKLLDGESP HQLYIQNYSC ASSSCLVLRK
WIFDPDRERQ LCQKDPLFRQ FVFHQAVADV NEGRLKCCQK MYQLKAIQNE GNAEEFLEMT
RRMSGYNEIA FPPCGCPTRK AGDVVMVVRF SSLLLTSDPP NAEIQVEISW DDIIEYHVDE
GGRAFQFNFK REGKRAKPIK LFSNYAEYMA ECFAQILFER QVASNWKPTR LITESVESSS
DHRTEIPSED V
//
