ID   A0A016WES8_9BILA        Unreviewed;       550 AA.
AC   A0A016WES8;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   Name=Acey_s0784.g2336 {ECO:0000313|EMBL:EYC37503.1};
GN   ORFNames=Y032_0784g2336 {ECO:0000313|EMBL:EYC37503.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC37503.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC37503.1}.
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DR   EMBL; JARK01000384; EYC37503.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016WES8; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR47027; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47027:SF8; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          113..335
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          16..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   550 AA;  62861 MW;  E73000734E2C0344 CRC64;
     MVPVRLGQAI GKTCRYGSAD GGVRKAPKHE STEGGEMRKR RHAGTRCVSG GPIVRKTPGE
     DEYVIPSVLP SEVRHAIKSV KNRTAPGPDR IRPEHLKNLP TALVSTLARL FTRYLSECKV
     PTQWKTSRTV LLYKKGDPQD MGNYRPICLL SVVYKLFTRV ILNRIERTLD EGQPCEQAGF
     RKGFSTIDHI YTLSPGSLKY HESTRCLSVS RSSISRKPST PISPFYDDIT IDVRRGVRQG
     DTVSPKLFTA TLEDVMRRLE WDNMGVRVDG RLLHHLRFAD DIVLITPSIS QAERMLADFD
     DACGKIGLQL NLTKTMFMRN GWVPDAPFSL NGTTISECSS YVYLGREVNM MNDLAPELGR
     RKRAAWGAYK SIEDVVKKTK NIRLRAHLFN TTVLPALTYA SETWALRKQD ENAVSVIERS
     IERVMLGMTR LTQVRAGIRS STLRQQSKIR DAAVYAKSSK IRWAGHVMRP NDHRWTRAVS
     DWTPRNVKRT TGRPPTRWSD FFTKSFKKRY DTLRVSRTDR THWTTLARER DKWKDCWRPL
     GLPNDQRESR
//