ID A0A016WPE8_9BILA Unreviewed; 881 AA.
AC A0A016WPE8;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Helicase ATP-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0568.g57 {ECO:0000313|EMBL:EYC41471.1};
GN Synonyms=Acey-smg-2 {ECO:0000313|EMBL:EYC41471.1};
GN ORFNames=Y032_0568g57 {ECO:0000313|EMBL:EYC41471.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC41471.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC41471.1}.
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DR EMBL; JARK01000168; EYC41471.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WPE8; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 47..84
FT /note="Upf1"
FT /evidence="ECO:0000259|Pfam:PF09416"
FT DOMAIN 253..325
FT /note="Helicase/UvrB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04851"
FT DOMAIN 355..454
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 457..635
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
SQ SEQUENCE 881 AA; 98772 MW; 8CC38F847B671E11 CRC64;
MDFDEVYGGG VGETLTFVET VDDDGVLHGG TQDSTFAFDH HFSIPTQSSQ LLSWIVNVPS
EQAQLRARHI TAAQASRLED LWKEHPKATV EDLDRPGVDT EPESVLLRYE DAFHYRRIFA
PLVREEAEFD RKTKESQTQS VGHVRWDQGL NKKHLAFFHL PKFMEGNHSD EIGIEMRAAS
SEKMPTDPRI NFTCEAVWNS TSFDRMYQAL NTLEKDPHCV SQYIFHKLMG HDIDEILFKV
QQPKRLSAPG LPELNHSQMH AVKTVLMRPL SLIQGPPGTG KTVTSATIVY HLVQQTQGQV
LVCSPSNIAV DQLAEKIHRT GLKVVRLYAK SREALDTNVE FLALHAQLKA LKESAELQKL
QQLKEEIGEL SAADQERYIN LKKMSEHKLL AAADVICCTC SSAADARLSR IKIKCVLVDE
STQATEPEVL VSIVRGVRQL ILVGDHCQLG PVILCKKVQY RMHPELSAFP SNVFYEGSLQ
NGVTQTERQL RGVDWEWPVP GRPMIFWSCY GQEEMSASGT SFLNRTEAAN VEKLASKLIR
GGMRPEQIGI ITPYEGQRSY IVQYMHTQGT LNSKLYENME IANVDAFQGR EKDLIIVTCV
RSNDHSGIGF LNDPRRLNVA LTRAKYGLII IGNAKVLARQ PLWNDLLTTF NQKNVIVEGP
INNLKSVQIT LPKPKPQRAN PAYPTDRYGI QRATYTLREY RGGYAREAPA MDPHSAISAH
SLRHAANLPV PLHMLQMFPP PPFPQQPPQQ RFPAGRRNVP AWPPTPQSMA AGPVRTGQSQ
NDYGGMYASQ ASQDPLIGVD AYGDVSMSGW TQSQSQNVAS MSMQSQLRIS KTIWLIYCSR
KDLELMDGHL TLLCDRYGSA VIGYEVLADR PVSTRCLLSE R
//
