ID A0A016WWK9_9BILA Unreviewed; 2227 AA.
AC A0A016WWK9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN Name=Acey_s0468.g2007 {ECO:0000313|EMBL:EYC44209.1};
GN ORFNames=Y032_0468g2007 {ECO:0000313|EMBL:EYC44209.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC44209.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC44209.1}.
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DR EMBL; JARK01000068; EYC44209.1; -; Genomic_DNA.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0019899; F:enzyme binding; IEA:UniProt.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT TRANSMEM 2072..2096
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2108..2125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2131..2157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2205..2226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 493..510
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 876..1055
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1433..1591
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 1630..1654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2227 AA; 251839 MW; 8CE27CC9BE989BED CRC64;
MADKKPDKSP AGAQTEVRQE FALSTLNEEL DIIMQDLKNL PQDLTAAPNV KLGKAQRPMV
EDAIRERVQQ VCDQLERLTQ STSGYRVFGK ELFALLHGEG IENIEDLRDF INTTGKDGEI
LEDICADLNT DVTQVRKAVR DLKKQTGRQQ QEVEMETDEG IDTNTCENTI QDYEQRFQLQ
DRVQAGEAHA RLDQPMTSAN SVPCSMPCTT HSAQEPNSRE AGQNGFSEWL DFLQANTCPT
PGVFYGKRNE NYREFMRRFR RKYRKVVQSD KDLIEILGDD HLGGRAKSIL LALPAAIVQQ
GFEAVAEELG KLVAADSTAG RLRALTELRS LRMRPNQSVA EFCVLLENLA RQANPDCTLE
DRSMEYAQIL LDNLAKWPEH VQLIAALHRV TPDRAYSEVK QLAITMEQSK MMFTTQEQRK
QFRQGNNWRS RATNYRDTNS GIILPEHSNR VNDCSRRMEP QRRDIAANNG RQNFNQPQPQ
PFQRVNGRNA ETRRCFKCSE VGHIGRHCPQ QQQANMARNQ RQLQTPHRMD HRVSQMIARG
HSMGITVREP RSSFEGLIGN QLWVTLEVLG ENLPAMIDSG SMISILPVGV LARAKKSGFD
VDTLEAIEVE GTLPVYDASN NRMKFLGGVR VDVQLVGGQR SMVSFFVADQ PGNEILLGTN
ALEGLGVYII VDSKHDKESA CTEFIHDEEG EQIKSVRSLR RVYMPPYTCC LIQAQCETEA
DEVVMWSSRR GVPTGVFKIS DKGLTLPIVN DGEDPLIIEN GEELGKWSTD KWSEGWENMD
LAVTGAATEN LSTEDRRALL SEQITSNLAS KVIQQDLAGV LDEFEDVFAV SDRELTRTNL
VEMNIDTGES SPIRLKARPV PLAVRQKLKD MLEDLQRRNI IERSKSDWAF PIVLVEKKDG
SLRLCVDYRE LNKRIKQDSY PLPTVEAVLQ SLAGKKFFST LDMCSGYWQI PLSKEAKEKS
AFTTPEGLFQ FTVTPFGLST SPPVFQRMMD MVLYDLTGSE VFCYIDDIII CTHTRERHLE
LLREICQRMR DAGLKLKAQK CVLLQTQVSF LGHLIDANGL HMDPRKVEVI KNYPTPTNIK
QLRTFLGMAS FYRKFCLGFS KQTSCLFALT SAKVKWSWDE EHNRAFEKVK KMISSGPVLS
QPDIEKARSG ERPFKIFTDA STYGLGAVLS QDGDDGQLHP LFFASKALTK AERRYHVTDL
EALAVVFAVR RFHMFIYGLP VVVMTDHQPL TALFKRKNVS ARVLRWSLEL QRYNLEVRYV
KGKANAVADA LSRGVAHLEE EEPLEGLGEA VVNEIRAEES SKWLKELEAD DQFAEIIKLL
RKNDLDGTVR LKGSNTPVRI SDFILDNGDL KMYQDDGTLV YVVPKEKRRE VFLESHEGTF
AGHFGPQRLL KKLRKQVFWP GMAKDIMKWS QECQKCFVSN PRQAIVPPLK PISTARPYEL
IGVDVLELGP TRNGNRYAVT VIDHFSKWAA AYPVADKSAE TIAKVLFQRW VAEGCRYPKA
IISDKGGEFE NKVMDELTTV MKIDHKFTKG YNPRENGITE RLNGTIVAML RRSTVVPVEW
DERLPFCMMA YNMTPHRATG ESPYFILHGM DPEFPSSIIP NGGITWYSMD KSMDEYKTAI
LQSMAEVHDR VKEHNERTRA RMKRDYDAKN EVDPSRHPKV GDRVYVVAPA EKSKCAHPKL
VSEWMGPFRV LQISENSALV ARMGQNSEPL RVQFDMLRIV PKCISDEQLV TVTSRGKRGR
KPRVAHVKLI TSPCFSGVKI DNVRMAGHVQ FICKDNCLAK AKLGDLKGVH FPGAFAKEPV
ITVWNAWKAA SLFIRTDIDM AEKVKHHTNG VISPDAKALV AVLRLAYDRC RDWTAFICST
AGVNKHVNVD GYDVTPLLDH AVKVVRMEML EGEKQNRPEK TGGTGYASPV YGRILEKDGR
RGSLETQIVT TFRHVRDVLD GWQHMRNWVI VWPVELNVTG ELVKEIIDRC KKHFEEGGVI
VTAWTPVMRS NVEMWKNTMG LWLTIDGILA KLARASQFYT TSRTRMENGR LFTEVSNDLL
SGPITFEEAS AGDCLGNFTV GMYSCIDVTV TFSASAFGII GTLLVPSILL VIASWLHFWV
HGSWSVPRTI SAALPFFLFA VLFLFRRDVV AAAPGLCCWF IFCLVITFLS LLEYFVVICC
GIRRSIRYTA NGHPEENPIG AAKETLEVAY DTRCANFRNN NGIDIIARVL FPLIFIIFLV
VFFLFFI
//
