ID   A0A016WWV7_9BILA        Unreviewed;       448 AA.
AC   A0A016WWV7;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN   Name=Acey_s0491.g2392 {ECO:0000313|EMBL:EYC43498.1};
GN   ORFNames=Y032_0491g2392 {ECO:0000313|EMBL:EYC43498.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC43498.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC43498.1}.
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DR   EMBL; JARK01000091; EYC43498.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016WWV7; -.
DR   STRING; 53326.A0A016WWV7; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR045046; Vps9-like.
DR   PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          182..391
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
SQ   SEQUENCE   448 AA;  50395 MW;  4123E3AF831BADC3 CRC64;
     MCLYFDLFCL MLNIVVISVV QLYAKVGEYF LPHIRTLRCA DGMWSLCERL TVERLLINSE
     VCCLQELHNE VSAKFLQLGL LSWNNKQHQL LLQRLVSSHT SVTQENCCML SSQLNSTEIE
     EAYRKLGHHH ALFGRCLSLL FSSPLSIAEL LHVVGQNQEV PLEECIHAVF GLLYGNCIFS
     TDEKAVLETL SCLIRVQLLS HSNPRLIIRK GTAAFPRLYK LYSESLYSAK IFLTAALHDS
     VMLVLCQDEV FLDVDPAKSP LRFPSADRIR RFGDDPTSAQ YHKRVAAHRK LIVEKLVLLA
     HSFIKGICDA ISCFPLGLIW LVQQLNTALI EVKRLTVDEA ALICTDLIVT NLLCPAIINP
     ENIGIISDTP ISHIARFNLM QIGQIIQVID SSFIFISFHP ILITEKVLKK AAFKSRLRGG
     VANGALWMYW RNATSTSADS YAGSQRSH
//