ID A0A016WZI9_9BILA Unreviewed; 974 AA.
AC A0A016WZI9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=LITAF domain-containing protein {ECO:0000259|PROSITE:PS51837};
GN Name=Acey_s0441.g1521 {ECO:0000313|EMBL:EYC45045.1};
GN Synonyms=Acey-nmr-1 {ECO:0000313|EMBL:EYC45045.1};
GN ORFNames=Y032_0441g1521 {ECO:0000313|EMBL:EYC45045.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC45045.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC45045.1}.
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DR EMBL; JARK01000041; EYC45045.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WZI9; -.
DR STRING; 53326.A0A016WZI9; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0017146; C:NMDA selective glutamate receptor complex; IEA:UniProt.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR006629; LITAF.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF377; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10601; zf-LITAF-like; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00714; LITAF; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS51837; LITAF; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Ion transport {ECO:0000256|ARBA:ARBA00023286};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..974
FT /note="LITAF domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013130708"
FT TRANSMEM 519..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 788..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 918..935
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 883..966
FT /note="LITAF"
FT /evidence="ECO:0000259|PROSITE:PS51837"
SQ SEQUENCE 974 AA; 109668 MW; D55B53A8C951B58E CRC64;
MIILAVLLLA HSIPAKPILK IAVLIFGEHN FEDHVHSVKT AYWEIFETTS TQLANYTVVA
EYIDGGVLRK KPFNSANRLQ LTDEVVCEQV INRSIAVVIY APSLHRETQP EYLSRVSSTA
YALGFYSIPT IGVMVREAEF SKKKIYPTFV RPTPSYADES FVFLNLLRRL DYRQVVVVSV
KGDRNGEQFV ELFEKKRKKY KIHVQSYIEL EINDSLNTSL AVRFEEFTSN IVVLYATKPH
AIMIFSAAEV TGKQKVWIVN EDASKASNVP DGAIASRLSQ TPLSALRSSF ASIKSSLEFL
DSLDETVNPP SGCGKDAVHS KWATDHGLQL LRAICSTSTS KITFNERCER ISVDYDILNY
NEGYKEVGAL NGAHLRLAED SIHWTGGGRK PLEITLPKHL RAVTILDPPF IYTTPIISLA
ECKNLGTVSV ELSPVNIVQV EGPWYPCPKY GYNYTYHYCC AGYAIDLLSN LSLPEPNTTI
DTSFTFSLHL NESYGAVTLG EKIPRDSPMQ SFLQPLKSAL WTSLLISVIM VGLVIFCLDL
KSPFDRFYKM DKSQMAADDP FLMEVANDRV NFGEAMWFVW GVLLNSGVSE KTPRSCAARV
LGIVWCGFCM IMVASYTANL AAFLVLDQPE KGLTGITDPR LRNPSANYSF GTVLNSNVYQ
YFKRHVELST MFRKMEAHNM EKVSDAVASL MNGSLDAFIW DSTRLDFEAA RQCELRTRGA
LFGRSAYGVG LQKNSPWTPH ITSAILRMAE SGIMEKLDAK WIDNKESKCV TEAHKSPARL
SLWNMKDVFI LVTGGVAAGA LCSTIEVIYG RRKARRGRER ALAARYVDKW RTIVHGGRMP
SHYNLSRPVI RRGFAGLEPC TLADIRKREL ARSKQKIGDR VFLHPSPFVP DLNFGRHSVA
LFCSRCRNLV ETDVHRECGL FAYVWCVIFV LLFLWPCSPL PCFMEAFADF VHICPVCSHK
IGRYRRCRRP KFYV
//
