ID   A0A016X2J1_9BILA        Unreviewed;       898 AA.
AC   A0A016X2J1;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   Name=Acey_s0407.g910 {ECO:0000313|EMBL:EYC46115.1};
GN   ORFNames=Y032_0407g910 {ECO:0000313|EMBL:EYC46115.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC46115.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC46115.1}.
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DR   EMBL; JARK01000007; EYC46115.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016X2J1; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR19446:SF415; REVERSE TRANSCRIPTASE-RELATED PROTEIN; 1.
DR   PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          477..727
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   898 AA;  103214 MW;  997E34AB6A1A6844 CRC64;
     MTICTFNART LASEASIEDL MVQARKIRYD VIGLTETRRH RPLNATFDTG EELFLGTCDS
     RGVGGVGVLV NTNLAMNIDS FEQLTTRIGR LRLRRCGSTP AVTVFIAYAP TFSYDEDEIE
     AFYMVLEKFY REDHTFYKVI VGDFNAKIGP RRTPEELHIG THGLQWNEQG ERLSELIMTT
     KTIHGNSQFQ KPTSLRWTWE SPGGEYHNEI DHIIVNRRHC LTDVGVVPKF YTGSDHRLLR
     ARFFFSRKGE KAAKYKKRSP KPIINWDLFT TLLSFIIFYY TQCRGTMLPF EVKHLHDSTK
     KAEGLRTTKR RQSHETFELI RQRGAARAAG NYQLTSELAR RCREAIKEDL KERRAAVLAE
     AAEAGRSIRN TRRDFANRKT KMTALRRPDG TITSSRMVME RVIYDFYSDL FDSHVQLPPC
     HLREDEYVIP SVLPSEVRHA IKSVKNRTAP GPDRIRPEHL KNLPTALVNT LARLFTRYLS
     ECKVPSQWKT SRTVLLYKKG DPQDIGNYRP ICLLSVVYQL FTRVILNRIE RTLDEGQPCE
     QAGFWKGFST IDHIHAVTRL IEVSREYKMP LCLTFIDLKK AFDTVETEAV LEALGTQGVP
     TQYIRIFLSS IATSRPESRH SRRHHYRRQK RGSTRRHCVA ETIHRHPRGR HATIGVGQYG
     SASCSRLLRF ADDIVLITPN ISQAERMLAD FDDACGKIGL QLNLTKTMFM RNGWVPDAPF
     SLNGTTISEC SSYVYLGREV NMMNDLAPEL GRRKRAAWGA YKSIEDVVKK TKNIRLRAHL
     FNTTVLPALT YASETWALRK QDENAVSVIK HSIERVMLGM TRLTQVRAGI RSSTLRQQSK
     IRDATVYAKS SNIRWAGHLM RLNDQCRQRL DSAERKAHDR KTTDPMVRIL HEVLQRTI
//