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Database: UniProt
Entry: A0A016X371_9BILA
LinkDB: A0A016X371_9BILA
Original site: A0A016X371_9BILA 
ID   A0A016X371_9BILA        Unreviewed;      1531 AA.
AC   A0A016X371;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   Name=Acey_s0412.g981 {ECO:0000313|EMBL:EYC45977.1};
GN   Synonyms=Acey-chd-1 {ECO:0000313|EMBL:EYC45977.1};
GN   ORFNames=Y032_0412g981 {ECO:0000313|EMBL:EYC45977.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC45977.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC45977.1}.
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DR   EMBL; JARK01000012; EYC45977.1; -; Genomic_DNA.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR   CDD; cd18666; CD1_tandem_CHD1-2_like; 1.
DR   CDD; cd18659; CD2_tandem; 1.
DR   CDD; cd17993; DEXHc_CHD1_2; 1.
DR   CDD; cd18793; SF2_C_SNF; 1.
DR   Gene3D; 2.40.50.40; -; 2.
DR   Gene3D; 6.10.140.1440; -; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR   InterPro; IPR040793; CDH1_2_SANT_HL1.
DR   InterPro; IPR025260; CHD1-like_C.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR   InterPro; IPR023780; Chromo_domain.
DR   InterPro; IPR023779; Chromodomain_CS.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   PANTHER; PTHR45623:SF14; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1; 1.
DR   PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR   Pfam; PF18375; CDH1_2_SANT_HL1; 1.
DR   Pfam; PF13907; CHD1-like_C; 1.
DR   Pfam; PF00385; Chromo; 2.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00176; SNF2-rel_dom; 1.
DR   SMART; SM00298; CHROMO; 2.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01176; DUF4208; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF54160; Chromo domain-like; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00598; CHROMO_1; 2.
DR   PROSITE; PS50013; CHROMO_2; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          211..300
FT                   /note="Chromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50013"
FT   DOMAIN          325..389
FT                   /note="Chromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50013"
FT   DOMAIN          431..601
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          729..880
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          972..992
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1028..1049
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1251..1313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1431..1531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1075..1126
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        32..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..131
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1264..1289
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1290..1306
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1443..1465
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1466..1493
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1494..1509
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1531 AA;  175110 MW;  BB77278C75096788 CRC64;
     MWQDESDDSS SHAGGSEEDV KATPVDATPV DSQQEETRDG DGSSAGEHDS DYENQEEDKV
     ESEDDNDNAP GSSTSSSSSS SSSGSDVPRR RPKGRLDEKT RKLLEDSNYL RRSSRSKQAD
     RKRKSSSPSE EEEEEASQSE ESSSDDESYK RSSKKGVPAR KSKGSRGRGT NSSRSAVDYT
     EKGSDEDLDE NDVLEWEDDK KSPSSVAANA ETIERVIKSR MGAQGATGSA TTCYNVAEKG
     DPNTPNATVL EQQFLIKWVG WSHLHNTWES EASIAAMGAN GVKKMQNFLK KQKEMEEWKR
     TADKEYIEFY ECEQVMSEEL CEEYKKVERI VAHQVSRDRN AEGVEATEYY VKWCGLSYSD
     CTWEDARLLP PEQIQAYHRR IDNYKAPSKN AVVLRKRPKF VKIEGMPSFL QPDGKDQTLR
     DYQLEGLNWM LHAWCKHNSC ILADEMGLGK TIQSIAFLAA LYHRYELYGP FLVVVPLSTM
     AAWQKEFAQW APDLNLVTYM GDTNSREQIR QFEWYVPGTK KIKVNAVLTT YEILLKDKPF
     LGSFHWAALA VDEAHRLKND ESLLYISLSS FNCDHRLLIT GTPLQNSLKE LWALLHFIMP
     EKFDSWAEFE SGHSDRDHKG IAALHRKLEP FLLRRVKKDV EKSLPPKLEQ ILRVDMTAQQ
     KQYYKWILTK NYRELSKGVK GSINGFVNLV MELKKCCNHT SLVRQYDHFE NDPQARLQQL
     LKSSGKLILL DKLLCRLKDT GHRVLIFSQM VMMLDILQEY LQLRRFPAQR LDGSMRADLR
     KQALDHYNAE GSTDFAFLLS TRAGGLGINL ATADTVIIFD SDWNPQNDLQ AMSRAHRIGQ
     TRQVNIYRLV TRNSMEEEIV ERAKRKLVLD HLVIQRMDTT GRTVLSKTSG SGARSIPFDK
     KELNDILKFG AADLFKEGDG EEQEPEVDID RILSVAETRD ADETQESGNE LLNSFKYANF
     SINEEQDVAA AAQHQVASSK ELDGEATGAD WDEIIPAAER EKLEEEERRK LAADLELAPR
     QRVKVDIEEA DDGDASASEG EAEGGRKKRK KAFGDFSGVE VKRFVRSFRK FAKPLQRLEA
     LAQDAELEEH SADELRKLAE ALLEGCEKAE EEHELKKNEV KADGEKTKDR GPSFKFAGVV
     DVNVRAIRKL HAELEPLHKV LSDNDAAADF KPPHKARSQK GWDVEWTSVD DTALLRGVYK
     YGLGSWEAIK MDPQLGLADK IFLKDKVRKP QPRHVQQRVD YLLKLMDKSA NGVRTQRAAP
     SGLPRKRKAP DDDQGKSAPV EEKRRREKEK EHSSHHKHHH HHSSQAKPSS ATRDKTLADQ
     LALVLIEKSI YGQALEDTND RPFSECVKMM RPVQKYIKKL TAAGSDKEAA KYLMRLGDNC
     RDQLDEMLKK KPKTNVRKWY NYMWIFLSKF VSQEPMEMLQ KYRELCAANH RHRHREHNHV
     QKEKSPHKHD GEKKKDKDRD KKDGKEQHKK KHHKEHKHDK EHKEHRSHKS HEGHKDRFPR
     DDPPAEYRSP LQDEYRSSPL VRPPLLSTTP R
//
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