ID A0A016X371_9BILA Unreviewed; 1531 AA.
AC A0A016X371;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=Acey_s0412.g981 {ECO:0000313|EMBL:EYC45977.1};
GN Synonyms=Acey-chd-1 {ECO:0000313|EMBL:EYC45977.1};
GN ORFNames=Y032_0412g981 {ECO:0000313|EMBL:EYC45977.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC45977.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC45977.1}.
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DR EMBL; JARK01000012; EYC45977.1; -; Genomic_DNA.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR CDD; cd18666; CD1_tandem_CHD1-2_like; 1.
DR CDD; cd18659; CD2_tandem; 1.
DR CDD; cd17993; DEXHc_CHD1_2; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 6.10.140.1440; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR040793; CDH1_2_SANT_HL1.
DR InterPro; IPR025260; CHD1-like_C.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623:SF14; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR Pfam; PF18375; CDH1_2_SANT_HL1; 1.
DR Pfam; PF13907; CHD1-like_C; 1.
DR Pfam; PF00385; Chromo; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01176; DUF4208; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00598; CHROMO_1; 2.
DR PROSITE; PS50013; CHROMO_2; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 211..300
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 325..389
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 431..601
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 729..880
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1251..1313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1431..1531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1075..1126
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 32..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1264..1289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1306
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1443..1465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1466..1493
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1494..1509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1531 AA; 175110 MW; BB77278C75096788 CRC64;
MWQDESDDSS SHAGGSEEDV KATPVDATPV DSQQEETRDG DGSSAGEHDS DYENQEEDKV
ESEDDNDNAP GSSTSSSSSS SSSGSDVPRR RPKGRLDEKT RKLLEDSNYL RRSSRSKQAD
RKRKSSSPSE EEEEEASQSE ESSSDDESYK RSSKKGVPAR KSKGSRGRGT NSSRSAVDYT
EKGSDEDLDE NDVLEWEDDK KSPSSVAANA ETIERVIKSR MGAQGATGSA TTCYNVAEKG
DPNTPNATVL EQQFLIKWVG WSHLHNTWES EASIAAMGAN GVKKMQNFLK KQKEMEEWKR
TADKEYIEFY ECEQVMSEEL CEEYKKVERI VAHQVSRDRN AEGVEATEYY VKWCGLSYSD
CTWEDARLLP PEQIQAYHRR IDNYKAPSKN AVVLRKRPKF VKIEGMPSFL QPDGKDQTLR
DYQLEGLNWM LHAWCKHNSC ILADEMGLGK TIQSIAFLAA LYHRYELYGP FLVVVPLSTM
AAWQKEFAQW APDLNLVTYM GDTNSREQIR QFEWYVPGTK KIKVNAVLTT YEILLKDKPF
LGSFHWAALA VDEAHRLKND ESLLYISLSS FNCDHRLLIT GTPLQNSLKE LWALLHFIMP
EKFDSWAEFE SGHSDRDHKG IAALHRKLEP FLLRRVKKDV EKSLPPKLEQ ILRVDMTAQQ
KQYYKWILTK NYRELSKGVK GSINGFVNLV MELKKCCNHT SLVRQYDHFE NDPQARLQQL
LKSSGKLILL DKLLCRLKDT GHRVLIFSQM VMMLDILQEY LQLRRFPAQR LDGSMRADLR
KQALDHYNAE GSTDFAFLLS TRAGGLGINL ATADTVIIFD SDWNPQNDLQ AMSRAHRIGQ
TRQVNIYRLV TRNSMEEEIV ERAKRKLVLD HLVIQRMDTT GRTVLSKTSG SGARSIPFDK
KELNDILKFG AADLFKEGDG EEQEPEVDID RILSVAETRD ADETQESGNE LLNSFKYANF
SINEEQDVAA AAQHQVASSK ELDGEATGAD WDEIIPAAER EKLEEEERRK LAADLELAPR
QRVKVDIEEA DDGDASASEG EAEGGRKKRK KAFGDFSGVE VKRFVRSFRK FAKPLQRLEA
LAQDAELEEH SADELRKLAE ALLEGCEKAE EEHELKKNEV KADGEKTKDR GPSFKFAGVV
DVNVRAIRKL HAELEPLHKV LSDNDAAADF KPPHKARSQK GWDVEWTSVD DTALLRGVYK
YGLGSWEAIK MDPQLGLADK IFLKDKVRKP QPRHVQQRVD YLLKLMDKSA NGVRTQRAAP
SGLPRKRKAP DDDQGKSAPV EEKRRREKEK EHSSHHKHHH HHSSQAKPSS ATRDKTLADQ
LALVLIEKSI YGQALEDTND RPFSECVKMM RPVQKYIKKL TAAGSDKEAA KYLMRLGDNC
RDQLDEMLKK KPKTNVRKWY NYMWIFLSKF VSQEPMEMLQ KYRELCAANH RHRHREHNHV
QKEKSPHKHD GEKKKDKDRD KKDGKEQHKK KHHKEHKHDK EHKEHRSHKS HEGHKDRFPR
DDPPAEYRSP LQDEYRSSPL VRPPLLSTTP R
//