ID A0A017HG88_9RHOB Unreviewed; 884 AA.
AC A0A017HG88;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 13-SEP-2023, entry version 48.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=Lokhon_00679 {ECO:0000313|EMBL:EYD73153.1};
OS Limimaricola hongkongensis DSM 17492.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Limimaricola.
OX NCBI_TaxID=1122180 {ECO:0000313|EMBL:EYD73153.1, ECO:0000313|Proteomes:UP000025047};
RN [1] {ECO:0000313|EMBL:EYD73153.1, ECO:0000313|Proteomes:UP000025047}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17492 {ECO:0000313|EMBL:EYD73153.1,
RC ECO:0000313|Proteomes:UP000025047};
RA Fiebig A., Goeker M., Klenk H.-P.P.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYD73153.1}.
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DR EMBL; APGJ01000003; EYD73153.1; -; Genomic_DNA.
DR RefSeq; WP_017927819.1; NZ_KK088649.1.
DR AlphaFoldDB; A0A017HG88; -.
DR STRING; 1122180.Lokhon_00679; -.
DR PATRIC; fig|1122180.6.peg.678; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_5; -.
DR Proteomes; UP000025047; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 3.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000025047}.
FT DOMAIN 703..719
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 629..636
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 884 AA; 95351 MW; B11D69B661E51153 CRC64;
MNTQAGTVTP MMAQFLEIKA AHRDALLFYR MGDFYEMFFD DAVAAAEALD IALTKRGKHM
GEDIAMCGVP VHAAESYLLT LIRKGFRVAI AEQLEDPAEA KKRGSKSVVK RDVVRLVTPG
TLTEESLLDA RRHNFLAAFS ELRDDCALAW VDISTGALSV LGCDRLALGP ELARLTPREL
LVAESAEQEL AEVTSNFDLA VTPLHRGAFD SAGGAARLAK LWKVASLDAF GSFSRAEISA
MAALVEYLDL TQKGRLPLLR PPQQEARMSA MRIDAATRRS LELTHAMGGG REGSLLQAID
RTVTAGGARL LERRVASPSC ALPAITARQA AVAHLTEDDR LRGDLRDALR GAHDLDRALS
RLALERGGPR DMAAIRSTLD VADRIAALTD GRDLPGPLAD AARDLGGQEE LHELLDQALV
AEPPLLARDG GFVAAGFDED LDAARRLRDE GRGVIAGMQA DYAAETGIQS LKIKHNNVLG
YFIETTATHA AKMLAPPLSD RFIHRQTTAN QVRFTTVELN EIETRILNAG GHALELEKRI
HDRLRAAILD QAGPLGQLAR ALSEIDLAAG LADLARSADW CRPTLDDSRA FHVEAGRHPV
VEQALRRAGE SFVGNDCDLG DAPLWLLTGP NMAGKSTFLR QNALIAVLAQ IGSFVPAASA
HIGIVSQIFS RVGASDDLAR GRSTFMVEMV ETAAILNQAD DRALVILDEI GRGTATYDGL
SIAWAVLEHL HDVNRCRGIF ATHYHEMTQL AAKLDGVATA TVAVREWQGE VIFLHEVRRG
TADRSYGVQV ARLAGLPASV VERARVVLQA LEQGEREGGG RKQTLIDDLP LFAAMPPASA
TAPAAPSKVE ERLRGTHPDE LTPRAALELL YELHGLLPQA SGRG
//
