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Database: UniProt
Entry: A0A017S5R3_9EURO
LinkDB: A0A017S5R3_9EURO
Original site: A0A017S5R3_9EURO 
ID   A0A017S5R3_9EURO        Unreviewed;       858 AA.
AC   A0A017S5R3;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   11-NOV-2015, entry version 8.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=EURHEDRAFT_485268 {ECO:0000313|EMBL:EYE92176.1};
OS   Aspergillus ruber CBS 135680.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1388766 {ECO:0000313|EMBL:EYE92176.1, ECO:0000313|Proteomes:UP000019804};
RN   [1] {ECO:0000313|Proteomes:UP000019804}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 135680 {ECO:0000313|Proteomes:UP000019804};
RX   PubMed=24811710; DOI=10.1038/ncomms4745;
RA   Kis-Papo T., Weig A.R., Riley R., Persoh D., Salamov A., Sun H.,
RA   Lipzen A., Wasser S.P., Rambold G., Grigoriev I.V., Nevo E.;
RT   "Genomic adaptations of the halophilic Dead Sea filamentous fungus
RT   Eurotium rubrum.";
RL   Nat. Commun. 5:3745-3745(2014).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KK088438; EYE92176.1; -; Genomic_DNA.
DR   EnsemblFungi; EYE92176; EYE92176; EURHEDRAFT_485268.
DR   Proteomes; UP000019804; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019804};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019804};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    429    454       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    466    486       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    553    571       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    583    606       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    649    669       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    761    784       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    790    814       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      100    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   858 AA;  98363 MW;  9FE42E75F1CF6D80 CRC64;
     MAPRDTFFRS ADMSLTQLYI ANEIGREVVS ALGELGQVQF RDLNPETNAF QRTFTKEIRR
     LDNVERQLRY FHTQMEKADI TMRSSNEFSD TLAAPLASEI DELAERSESL EQRIASLNDS
     YETLKKREVE LSEWRWVLRE TGGFFDRAHT HTEDIRQSFD NDEAPLLRDV EQQPQRGVNG
     DAEQQQQQQS FLEMNIGFVA GVIPRDRIGA FERILWRTLR GNLYMNQSEI PEPVVDPTTN
     EETRKNVFVI FAHGKHIITK IRKISESLGA SLYGVDENSE LRRDQIHEVN TRLGDVGNVL
     RNTKNTLDAE LRQIARSLAA WMIIVKKEKA VYDTLNRFSY DQARKTLIAE AWCPTNSLGL
     IKATLQDVND RAGLTVPTII NQIRTNKTPP TYMRTNKFTE GFQTIVNAYG IPKYSEVNPA
     LYTVVTFPFM FAVMFGDLGH GLLMTLAAAA MILWEQKLLK TKLDELSYMA FYGRYIMLMM
     GLFSMYTGFL YNDIFSKAFT FFPSQWQWPD DIQRGQAVEA TLKDGYRFPI GLDWNWHEAE
     NSLLFSNSMK MKMSIVLGWA HMTYALFLQY VNARHFKSKV DIIGNFIPGF IFFQSIFGYL
     VLTIVYKWSV DWAAKGQSPP GLLNMLIFMF LSPGTVEEPL YPGQSGVQVT LLLLALVQVP
     LMLFFKPFYL RRENERARAQ GYRGLGEPAR VSALEDDNGR DSMASEGDGT NEGTAMIAQD
     LDADDEEHEE FDFSEVMIHQ VIHTIEFCLN CISHTASYLR LWALSLAHQQ LSIVLWDMTI
     GGAFEQEDPT IRIIMIVVTF FMWFTLTIAI LCVMEGTSAM LHSLRLHWVE AMSKHFHGEG
     IPFVPFSFKT LLEEEPVD
//
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