GenomeNet

Database: UniProt
Entry: A0A022LQJ0_9MICO
LinkDB: A0A022LQJ0_9MICO
Original site: A0A022LQJ0_9MICO 
ID   A0A022LQJ0_9MICO        Unreviewed;       255 AA.
AC   A0A022LQJ0;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=NAD(P)H-hydrate epimerase {ECO:0000256|HAMAP-Rule:MF_01966};
DE            EC=5.1.99.6 {ECO:0000256|HAMAP-Rule:MF_01966};
DE   AltName: Full=NAD(P)HX epimerase {ECO:0000256|HAMAP-Rule:MF_01966};
GN   Name=nnrE {ECO:0000256|HAMAP-Rule:MF_01966};
GN   ORFNames=H489_0105480 {ECO:0000313|EMBL:EYT65926.1};
OS   Curtobacterium flaccumfaciens UCD-AKU.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Curtobacterium.
OX   NCBI_TaxID=1292022 {ECO:0000313|EMBL:EYT65926.1, ECO:0000313|Proteomes:UP000019755};
RN   [1] {ECO:0000313|EMBL:EYT65926.1, ECO:0000313|Proteomes:UP000019755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCD-AKU {ECO:0000313|EMBL:EYT65926.1,
RC   ECO:0000313|Proteomes:UP000019755};
RX   PubMed=23682147;
RA   Flanagan J.C., Lang J.M., Darling A.E., Eisen J.A., Coil D.A.;
RT   "Draft Genome Sequence of Curtobacterium flaccumfaciens Strain UCD-AKU
RT   (Phylum Actinobacteria).";
RL   Genome Announc. 1:E00244-13(2013).
CC   -!- FUNCTION: Catalyzes the epimerization of the S- and R-forms of
CC       NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or
CC       heat-dependent hydration. This is a prerequisite for the S-specific
CC       NAD(P)H-hydrate dehydratase to allow the repair of both epimers of
CC       NAD(P)HX. {ECO:0000256|HAMAP-Rule:MF_01966}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6R)-NADHX = (6S)-NADHX; Xref=Rhea:RHEA:32215,
CC         ChEBI:CHEBI:64074, ChEBI:CHEBI:64075; EC=5.1.99.6;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01966};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6R)-NADPHX = (6S)-NADPHX; Xref=Rhea:RHEA:32227,
CC         ChEBI:CHEBI:64076, ChEBI:CHEBI:64077; EC=5.1.99.6;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01966};
CC   -!- COFACTOR:
CC       Name=K(+); Xref=ChEBI:CHEBI:29103;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01966};
CC       Note=Binds 1 potassium ion per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_01966};
CC   -!- SIMILARITY: Belongs to the NnrE/AIBP family. {ECO:0000256|HAMAP-
CC       Rule:MF_01966}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|HAMAP-Rule:MF_01966}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYT65926.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; APJN01000021; EYT65926.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A022LQJ0; -.
DR   HOGENOM; CLU_024853_0_2_11; -.
DR   Proteomes; UP000019755; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0052856; F:NADHX epimerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0052857; F:NADPHX epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.10260; YjeF N-terminal domain; 1.
DR   HAMAP; MF_01966; NADHX_epimerase; 1.
DR   InterPro; IPR004443; YjeF_N_dom.
DR   InterPro; IPR036652; YjeF_N_dom_sf.
DR   Pfam; PF03853; YjeF_N; 1.
DR   SUPFAM; SSF64153; YjeF N-terminal domain-like; 1.
DR   PROSITE; PS51385; YJEF_N; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|HAMAP-Rule:MF_01966};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_01966};
KW   NAD {ECO:0000256|HAMAP-Rule:MF_01966};
KW   NADP {ECO:0000256|HAMAP-Rule:MF_01966};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01966};
KW   Potassium {ECO:0000256|HAMAP-Rule:MF_01966}.
FT   DOMAIN          1..248
FT                   /note="YjeF N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51385"
FT   BINDING         61..65
FT                   /ligand="(6S)-NADPHX"
FT                   /ligand_id="ChEBI:CHEBI:64076"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01966"
FT   BINDING         62
FT                   /ligand="K(+)"
FT                   /ligand_id="ChEBI:CHEBI:29103"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01966"
FT   BINDING         150
FT                   /ligand="K(+)"
FT                   /ligand_id="ChEBI:CHEBI:29103"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01966"
FT   BINDING         190
FT                   /ligand="(6S)-NADPHX"
FT                   /ligand_id="ChEBI:CHEBI:64076"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01966"
FT   BINDING         193
FT                   /ligand="K(+)"
FT                   /ligand_id="ChEBI:CHEBI:29103"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01966"
SQ   SEQUENCE   255 AA;  25217 MW;  3FAC93704010512D CRC64;
     MDGYGGDQIR AAERPHLDAG EPLMQRAAAG LARIVGDLLD DPAVRPVDGP GSVLVLAGSG
     DNGGDALFAG ARLAAAGRHV AVLRVGSRVH AAGLAAALDA GARLLDGASG TSGPNAGGAA
     DILRAAGRSD GERLAAVATE AALEADLVLD GILGIGVHGA TALRSPAREV VDAIRELARD
     QRAPFVVAVD VPSGVDVDTG GVADDHVLHA DVTVTFGGVK AGLLTGPAAT LAGRIELVDV
     GIGADLATME PLIRT
//
DBGET integrated database retrieval system