ID A0A022MN89_9ACTN Unreviewed; 1565 AA.
AC A0A022MN89;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=CRISPR-associated protein Cse1 {ECO:0000313|EMBL:EYT83384.1};
GN ORFNames=CF54_07860 {ECO:0000313|EMBL:EYT83384.1};
OS Streptomyces sp. Tu 6176.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1470557 {ECO:0000313|EMBL:EYT83384.1, ECO:0000313|Proteomes:UP000020060};
RN [1] {ECO:0000313|EMBL:EYT83384.1, ECO:0000313|Proteomes:UP000020060}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tu 6176 {ECO:0000313|EMBL:EYT83384.1,
RC ECO:0000313|Proteomes:UP000020060};
RA Olano C., Cano-Prieto C., Mendez C., Salas J.A.;
RT "Draft genome sequence of Streptomyces sp. Tu 6176, producer of the
RT cytotoxic benzoxazol nataxazol.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYT83384.1}.
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DR EMBL; JFJQ01000233; EYT83384.1; -; Genomic_DNA.
DR HOGENOM; CLU_250011_0_0_11; -.
DR Proteomes; UP000020060; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd09729; Cse1_I-E; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.132.100; -; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041372; Cas3_C.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR013381; CRISPR-assoc_prot_Cse1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR NCBIfam; TIGR02547; casA_cse1; 1.
DR PANTHER; PTHR47963:SF9; CRISPR-ASSOCIATED ENDONUCLEASE_HELICASE CAS3; 1.
DR PANTHER; PTHR47963; DEAD-BOX ATP-DEPENDENT RNA HELICASE 47, MITOCHONDRIAL; 1.
DR Pfam; PF18395; Cas3_C; 1.
DR Pfam; PF18019; Cas3_HD; 1.
DR Pfam; PF09481; CRISPR_Cse1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 28..236
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 964..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1237..1265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1565 AA; 169848 MW; 2743CD5BA5D6B810 CRC64;
MTAHSRSEPA PHALSASARS AWAKHDRKTD GWLPLWRHLR DSASVAGKLW EDWLPASVRR
LVSEPFPGGE DDAARLLRFL AASHDIGKCT PAFACQVEQL AGRMRDHGLD MPTAKEYGQD
RKLAPHGLAG QLILQEWMGQ RFGLGARVAG QFAVVAGGHH GVPPGSQQIH DLQLRPYLMR
HPGPSEDVWR RTQAELLDWC AESTGMTSLL PTWHSVRLPQ PVQVLLTAVV ILSDWIASAP
ELFPYAPESW HPVGAEGERR RLLAAWEGLD LPGPWQPRLP ASAPQELFRQ RFPTLRDAAL
RPVQREAVRL AQEMDPGGLL IVEAPMGEGK TEAALAAAEI LAARSGAGGL LMALPTRATG
DAMFARLLSW LDALPADGSR TRSVVLAHAK AALTESWSGL LREGSRSIAA VEPDALRHEV
TPNGKDQETP RHPGALHAHQ WLRGRKKQLL ASFAVGTVDQ VLFAALKSRH LALRHLAVAG
KVVVIDEVHA YDAYMNRYLD RTLEWLAAYR VPVVLLSATL PAGRRRALAA AYAGEDGAAS
VTAEAGAYPL LTAVSPGREA LTVRPDPASD RGTAVVMERV NDDLAALAER LDAELADGGC
ALVVRNTVGR VLETADALKD RFGEDQVTVV HSRFLAADRA ANDAALLARF GPSGERPARH
VVVASQVVEQ SLDVSFDLLV TDLAPVDLVL QRMGRLHRHR SPRPDRLSTP RCLVTGVDWT
ASPPAPVAGT QAVYPGDWPL LRSLAAFAPH LDGVPVRLPH DISPLVQSAY GEEPLGPAAW
AGAMAAAGER HRALLTEKRR RADGFLLGPV QRPGRPVYGW LEAHAGDADD SRTGRAQVRD
SEETLEVLVV QRQTDGRLTT VPWLDEGRED GRGGLELPVD FPPSRRAAEA VAASALTLPG
RFGKPWMIDR TIADLEKFLV PAWQAKECPW LAGELILVLD ERCQTRLAGF ALSYSRAEGL
RVTAPRTAGS DQQQTAASAA SEESGGVAKD AGRESDMVSP PARLSGRCAT DDDGPAAFNL
VREAWVPVQH LDGTVTELSL YEVFAQADTL RGLVGDVPTQ NPVLLRLLLA VLHDALEGPA
SLEDWEDLWH SPAPFTVAAD YLRSHADRFE LFDVERPFFQ VAGLRTGKDE IAPLSRIVAD
VPTGSALFSM RRPGVNRLSF AEAARWLLHA HAFDTSGIKS AMKGDETRSR AGKVYPLGVG
SLGHLGCVFA EGDTLRETLL LNLVPFEEAY AGSEFAEQTG EDRPVWRQDE PYGPGPRGER
AGGAEPLGLR DLYTWQSRRI RLCATGGAVT GVVLGYGDPL LLSAPWVLEP MSGWRRSPAQ
EKKQSRALVY TPDRHDPNRS AWRGLGALLP ARAQAQESEA RGEPPERLRS GVTRWYTQVI
TESEIDPGKL IRLRLTGVVY GTQQSVIDEI VDDSVVLPVV TLHRTNPVYG AAAVDAVSDA
EEAVTALGHL AANLVRAAGG DRPEAAAAAA RDLGYGILDG PYRAWLRELA RQPDLVAARR
TWRESVRRQM LRLARQEVRS AGPAAGEGRV IDLPGRGECL MDAGRAELWF RARLRRVLGP
SPITT
//
