ID A0A022PTY3_ERYGU Unreviewed; 857 AA.
AC A0A022PTY3;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0000259|Pfam:PF00931};
DE Flags: Fragment;
GN ORFNames=MIMGU_mgv1a021341mg {ECO:0000313|EMBL:EYU17710.1};
OS Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU17710.1, ECO:0000313|Proteomes:UP000030748};
RN [1] {ECO:0000313|EMBL:EYU17710.1, ECO:0000313|Proteomes:UP000030748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA Schmutz J., Willis J.H., Rokhsar D.S.;
RT "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT population shotgun sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; KI632363; EYU17710.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A022PTY3; -.
DR Proteomes; UP000030748; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000030748}.
FT DOMAIN 169..422
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT NON_TER 857
FT /evidence="ECO:0000313|EMBL:EYU17710.1"
SQ SEQUENCE 857 AA; 98995 MW; 54DA72B011123DDE CRC64;
MAYGAVCCLE LTIDRLLKSS HISINVQNSS HQILKHLYDE ILSLKEALGE FDKRRSTINM
KMVKTLEAEI IDAIYEFEDV IDSHLSNQFH SPQSEEETDH PRLMLFSVDL HQIKQDVDSV
IETVNEMKRA YIHELCNPSP EDEDDVVPSI NYFDGHNESN MVGLSRLFTR IKDRLVYSSQ
SERMIVSLYG MAGIGKTTLA NKLFQDPFIS NSYDIHVFVT IGPKYRVADI LVDILTQMNH
ADDIMLIEGE KKIVELKRMV FESLNCWRYL IVLDDVWDKE LFSELVNLFP DQKNGSRVLL
TTRLREVAQC ANYLSTLRIP FLDKKESWAL LRHKVFDEMP VICSGKHLNF PTMPCPHELE
KPGKKIAENC EGLPLTIITV ANILSKADKT IEYWNEVADD KKNSVYKDAY DQMSKVLYPS
YDYLDQHLKA CFLYLGSFPQ NHSVHGYQLI NLWSVEGFLN PNPTHYSDAT VAFEKGTYAY
LDELHSKNVI MYHKEKHGQH LHSSFWYMCN KEAAKTKFFY AFNCRADALP EEGIKYQRRL
CIRNNILFAI EDVKDSMASA ATVRSLLCTG VFQEYPVPLC LEHLRLLRVL EAISIRFYEF
PMEVLKLAQL RYLALTYDGN LPTSISKLWN LQHLIVDRHL SIIKSGGNLS YLPIEIWNMK
ELKHIQTMGS NLPHPCEGSL LPNLLKLRDV GPQSCTKDVL QNIPNMKELA IKIELPPDAT
EPLRCFDHIS HLHQLGQLEC YIMNPILKTQ VVSPLAPLSD LPSSLTMLTL SGLGYPWEEM
NKISSLPNLR HLKLKCYAFR GPKWEVHDNE FQRIEVLNIE DTDLVHWKFV TTSSCFYEIK
WFSFEHCYKL KEIPLSF
//
