ID A0A022QGS1_ERYGU Unreviewed; 498 AA.
AC A0A022QGS1;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN ORFNames=MIMGU_mgv1a005065mg {ECO:0000313|EMBL:EYU27907.1};
OS Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU27907.1, ECO:0000313|Proteomes:UP000030748};
RN [1] {ECO:0000313|EMBL:EYU27907.1, ECO:0000313|Proteomes:UP000030748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA Schmutz J., Willis J.H., Rokhsar D.S.;
RT "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT population shotgun sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR EMBL; KI631456; EYU27907.1; -; Genomic_DNA.
DR RefSeq; XP_012849260.1; XM_012993806.1.
DR AlphaFoldDB; A0A022QGS1; -.
DR STRING; 4155.A0A022QGS1; -.
DR GeneID; 105969076; -.
DR KEGG; egt:105969076; -.
DR eggNOG; KOG1116; Eukaryota.
DR OMA; NYKTLMT; -.
DR OrthoDB; 374620at2759; -.
DR PhylomeDB; A0A022QGS1; -.
DR Proteomes; UP000030748; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017050; F:D-erythro-sphingosine kinase activity; IEA:UniProt.
DR GO; GO:0001727; F:lipid kinase activity; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR GO; GO:0046512; P:sphingosine biosynthetic process; IBA:GO_Central.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR045540; YegS/DAGK_C.
DR PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF19279; YegS_C; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030748};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 106..248
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 498 AA; 54685 MW; 7BBDB1A769AE9091 CRC64;
MDQPEIGEFI LSEQVRVNGR ITAATLSSGG ELGWGDRRLD VKKQVLGFSV EGSEIKIRAV
VEAAAGSWCS GDKTKLIRKC FTLELLSIDS LRLWSQKLQE YLDSLGRPKR LFVFVNPYGG
KKSASTIFVS DVKPLLDDAS VEYTVQETKY QLHAKEVARS LDLAKYDGIV CVSGDGILVE
VLNGLLIRED WENAIKIPLG VVPAGTGNGM VKSLLDSCGE PCAASNATMS IIRGHKRSLD
VATISQGDTK FFSMLMLAWG LVADIDIESE KYRWMGSARL DFYGLQRILG LRKYNGSIIF
VPASGFESYG EPIDVEKEVI FEGESKPKSD DGPVTTQDYG YQGPKVDMKS LNWRKINGPF
VSIWLHNVPW GGEDTMAAPD AQFSDGCLDL IMIKDCPKLS LLMLMNGLND GSHVKSPHVS
YLKVKAFILQ PGPRVDDQTK AGIIDVDGEV LARGKGSYKS EEKTLMSYDK LLIKVDQGLA
TLFAPSLDLA DLIPIPRD
//
