ID   A0A022QNJ9_ERYGU        Unreviewed;      1110 AA.
AC   A0A022QNJ9;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE            EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN   ORFNames=MIMGU_mgv1a000505mg {ECO:0000313|EMBL:EYU28878.1};
OS   Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX   NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU28878.1, ECO:0000313|Proteomes:UP000030748};
RN   [1] {ECO:0000313|EMBL:EYU28878.1, ECO:0000313|Proteomes:UP000030748}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX   PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA   Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA   Schmutz J., Willis J.H., Rokhsar D.S.;
RT   "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT   population shotgun sequencing.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC   -!- FUNCTION: Probably involved in the RNA silencing pathway and required
CC       for the generation of small interfering RNAs (siRNAs).
CC       {ECO:0000256|RuleBase:RU363098}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC         ECO:0000256|RuleBase:RU363098};
CC   -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC       ECO:0000256|RuleBase:RU363098}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KI631311; EYU28878.1; -; Genomic_DNA.
DR   RefSeq; XP_012847562.1; XM_012992108.1.
DR   RefSeq; XP_012847563.1; XM_012992109.1.
DR   AlphaFoldDB; A0A022QNJ9; -.
DR   STRING; 4155.A0A022QNJ9; -.
DR   GeneID; 105967512; -.
DR   KEGG; egt:105967512; -.
DR   eggNOG; KOG0988; Eukaryota.
DR   OMA; CYNEGYE; -.
DR   OrthoDB; 5477883at2759; -.
DR   PhylomeDB; A0A022QNJ9; -.
DR   Proteomes; UP000030748; Unassembled WGS sequence.
DR   GO; GO:0031380; C:nuclear RNA-directed RNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IBA:GO_Central.
DR   GO; GO:0030422; P:siRNA processing; IBA:GO_Central.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF55; RNA-DIRECTED RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030748};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU363098};
KW   RNA-mediated gene silencing {ECO:0000256|RuleBase:RU363098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
SQ   SEQUENCE   1110 AA;  127398 MW;  FB8448FE0A5D68BE CRC64;
     MGRTIQVFGF PYLVAAELVK KFLENYTGEG TVIALEVKTA KVGRRAYARV QFTNIRCAET
     IIDLAKNRLY YGTSYLKAYE SDIDIVQNPR TFAHEMENVT LNFGCQISPH KFSVLWKGES
     VTVKFGTGMK KMHFFLRHNS VEYKMQLSYE NIWQIVLYNS YGQSSKLLVI QLFGAPRIYK
     KLSGSVYSYF MVTQDDQWVR TTDFTQSLIG QSSSLCLQLP YGMRLPNFRD NFLYYKESET
     PFRLETGVPF SHNSDLVPIV RPPIDIKLPY TLLFKVCSLV QTGCLPGPKL DRSFFDLVNP
     AKHDIRYIEH ALEKLYYLKE CCYNPAAWLK EQYERYRTSK EHPKSPAICL DDGLVYVHRV
     QVTPTRVYFS GPEVNVSNRV LRHYRDYIDN FLRVSFVDEE WDKMYSTDLS PRVAAGDENK
     RTKLYERVIS ILRDGVRIGD RKFDFLAFSS SQLRDNSLWM FAPTDGLNAD GIREWMGDFS
     SIRNVAKYAA RLGQSFGSST ETLSVSKREI EEIQDVKNGT EYTFSDGIGK ISEDFARQVA
     AKCGVRSSTP SAFQIRYGGY KGVVAVDPSS KKKLSLRPSM LKYQSDNTKL DVLAWSKYQP
     CFLNRQIITL LSTLGVKDHV FEKRQREAVA QLDDVLIDPM RAQEALDLMS PGENTHILKE
     MLKCGYEPDG EPFLSMMLQT FRASKLLDLR VKARVFIPKA RQMMGCLDET GILKYGQVFV
     RYSGAVKRGL FDDSYDNSTA NERFDPVRGK VVVAKNPCLH PGDVRVLTAV DVPELRHMVD
     CVVFPKNGKR PHPNECSGSD LDGDIYFVCW DSDLIPTKQV EPMDYNPAPT TRLDHDVTIE
     EVEDYFTNYI VNDSLGIIAN AHTVFADKEP LMALSEPCLE LARLFSIAVD FNKTGIPAEI
     PPHLRVKEYP DFMEKPDKIN YASSRVIGKL FREVKDIAPQ TSSFRSFTKE VARRSYDPDM
     EVDGFEDHID EAFLHKTEYD YKLGNLMEYY GVKTEAEVLS GGIMKMSKTF DRRKDAEAIG
     AAVRSLRNEA RSWFKKGTEA DDVYAKASAW YYVTYHPDYF GCYNEGMKRD HYLSFPWCVY
     DKLVKIKKDN SRRASQMASL RRQFNDRVRI
//