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Database: UniProt
Entry: A0A023WZP8_9ACTN
LinkDB: A0A023WZP8_9ACTN
Original site: A0A023WZP8_9ACTN 
ID   A0A023WZP8_9ACTN        Unreviewed;       450 AA.
AC   A0A023WZP8;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   27-SEP-2017, entry version 27.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=RradSPS_0001 {ECO:0000313|EMBL:AHY45284.1};
OS   Rubrobacter radiotolerans.
OC   Bacteria; Actinobacteria; Rubrobacteria; Rubrobacterales;
OC   Rubrobacteraceae; Rubrobacter.
OX   NCBI_TaxID=42256 {ECO:0000313|EMBL:AHY45284.1, ECO:0000313|Proteomes:UP000025229};
RN   [1] {ECO:0000313|EMBL:AHY45284.1, ECO:0000313|Proteomes:UP000025229}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RSPS-4 {ECO:0000313|EMBL:AHY45284.1,
RC   ECO:0000313|Proteomes:UP000025229};
RA   Egas C.C., Barroso C.C., Froufe H.J.C., Pacheco J.J.,
RA   Albuquerque L.L., da Costa M.M.S.;
RT   "Complete genome sequence of the Radio-Resistant Rubrobacter
RT   radiotolerans RSPS-4.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP007514; AHY45284.1; -; Genomic_DNA.
DR   EnsemblBacteria; AHY45284; AHY45284; RradSPS_0001.
DR   KEGG; rrd:RradSPS_0001; -.
DR   PATRIC; fig|42256.3.peg.1; -.
DR   KO; K02313; -.
DR   Proteomes; UP000025229; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000025229};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000025229}.
FT   DOMAIN      144    272       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      356    425       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     152    159       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   450 AA;  51270 MW;  138348A37DD3B6A7 CRC64;
     MLRREEQVWS EVLDNVSEQI HTPSFKVWFE GTYPMNLYED AFEISVPNIL AKEYIESKFK
     PLLEEALDSV TGRDGTSLIV TVGGENARRD TPVRSDVEAA ESILNARPTR SVRVKYTFDS
     FVTGAGNRFA HAAALAVSEN PGTQYNPLFI YGASGLGKTH LLRAVGQYIE EQDPGSRVRY
     VTCEQFTNDF INSMRDNAPL QFQKRYREND VLLIDDIQFL ENKIETQEAF FHTFNALYDE
     EKQVVIASDR HPKHIETLEQ RLVSRFEWGL IADISPPDLE TRIAILRKKA ILDKLEVDDE
     VLTFIASKVL TNIRELEGAL VRILAYASLY SRQVTVALAE EVLRDILPDQ AYREIPIELI
     QLEVCRYFGI SKQDLIGASR SKNIAYPRQV AMHLSRELTN ESLPKIGKAF GGRDHSTVMH
     ATRKISDAIN SDRDVFNQIH EITQSIKTKR
//
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