GenomeNet

Database: UniProt
Entry: A0A024GNQ8_9STRA
LinkDB: A0A024GNQ8_9STRA
Original site: A0A024GNQ8_9STRA 
ID   A0A024GNQ8_9STRA        Unreviewed;       726 AA.
AC   A0A024GNQ8;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=alpha-1,2-Mannosidase {ECO:0000256|RuleBase:RU361193};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361193};
GN   ORFNames=BN9_096570 {ECO:0000313|EMBL:CCI48519.1};
OS   Albugo candida.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Albuginales; Albuginaceae; Albugo.
OX   NCBI_TaxID=65357 {ECO:0000313|EMBL:CCI48519.1, ECO:0000313|Proteomes:UP000053237};
RN   [1] {ECO:0000313|EMBL:CCI48519.1, ECO:0000313|Proteomes:UP000053237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ac Nc2 {ECO:0000313|EMBL:CCI48519.1,
RC   ECO:0000313|Proteomes:UP000053237};
RA   Gardiner A., Kemen E., Schultz-Larsen T., MacLean D., Van Oosterhout C.,
RA   Jones J.D.G.;
RT   "Recombination and specialization in a pathogen metapopulation.";
RL   Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR601382-2};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 47 family.
CC       {ECO:0000256|ARBA:ARBA00007658, ECO:0000256|RuleBase:RU361193}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCI48519.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CAIX01000231; CCI48519.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A024GNQ8; -.
DR   STRING; 65357.A0A024GNQ8; -.
DR   InParanoid; A0A024GNQ8; -.
DR   OrthoDB; 942598at2759; -.
DR   Proteomes; UP000053237; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004571; F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR044674; EDEM1/2/3.
DR   InterPro; IPR001382; Glyco_hydro_47.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR036026; Seven-hairpin_glycosidases.
DR   PANTHER; PTHR45679; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2; 1.
DR   PANTHER; PTHR45679:SF2; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3; 1.
DR   Pfam; PF01532; Glyco_hydro_47; 1.
DR   Pfam; PF02225; PA; 1.
DR   PRINTS; PR00747; GLYHDRLASE47.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF48225; Seven-hairpin glycosidases; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRSR:PIRSR601382-2};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycosidase {ECO:0000256|RuleBase:RU361193};
KW   Hydrolase {ECO:0000256|RuleBase:RU361193};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR601382-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053237}.
FT   DOMAIN          595..685
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   ACT_SITE        123
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT   ACT_SITE        263
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT   ACT_SITE        358
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT   ACT_SITE        380
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT   BINDING         465
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-2"
SQ   SEQUENCE   726 AA;  82182 MW;  4061ACA57B21ADFE CRC64;
     MRLDGFVWLL MYGSPQLYAR EFHSSERIHL KNKAREMFYH GYNNYMEHAF PWDELKPLTC
     EGRRWDRRER GDLDQTLGGF SLTLIDSLDM LAILGDHKEF RRAVKLVIQH VTFDRNVTVS
     VFESAIRVIG GLLSAHVLAS SDYVGLMPPP EYTNELLELA VDLATRLLPA FDTPTGIPMD
     RINLLHGISK HGPFVTCPAA GSVLVEFSYL SRLSKNPIFE QKARIAVLAM WERRSQLDLL
     GSSIDVLSGT WTSSHVGIGA GTDSFYEYLL KYHILTGEAS WLDIFNSSYT AVEAHTKFND
     LHVEVDMHYG NRRIRYPRVS ALQAFWPGLQ VLAGDVINAV KSHDKLFDLW VKFGAMPELF
     DLRGGGAVVE WARASPLRPE LIESTYHLYQ ATRNHKYLKV GRKLLHDIEA VSRVPCGYAA
     VKDIYTLEVE DRMDSYFLSE TIKYLYLLFS DDPSVIVPST YIGKTHTVSN VSAFGTTNCF
     DGEGYWTRPV KSSEIIFSTE GHILLTAPEL YRRNSSHQMA ILHQCESSTG FENNQVESLS
     SRKYSSSGYM PLGLSVRYKN THVGTILASP AKFGQQIINT KLTLEAFFDL EPVGNGCDTI
     SPSSLLSERI SGKMVMVYRG NCTFARKALN LEQAGAAGVV IINTARVPYK KYRTQFYLIW
     DDRSKIGQNV SIPVLMVLAE DVNRLVQLIK DHELKSLLTV KNHRKHKQSF LEEEDEIVVS
     LSSWLW
//
DBGET integrated database retrieval system