ID A0A024GNQ8_9STRA Unreviewed; 726 AA.
AC A0A024GNQ8;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=alpha-1,2-Mannosidase {ECO:0000256|RuleBase:RU361193};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361193};
GN ORFNames=BN9_096570 {ECO:0000313|EMBL:CCI48519.1};
OS Albugo candida.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Albuginales; Albuginaceae; Albugo.
OX NCBI_TaxID=65357 {ECO:0000313|EMBL:CCI48519.1, ECO:0000313|Proteomes:UP000053237};
RN [1] {ECO:0000313|EMBL:CCI48519.1, ECO:0000313|Proteomes:UP000053237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ac Nc2 {ECO:0000313|EMBL:CCI48519.1,
RC ECO:0000313|Proteomes:UP000053237};
RA Gardiner A., Kemen E., Schultz-Larsen T., MacLean D., Van Oosterhout C.,
RA Jones J.D.G.;
RT "Recombination and specialization in a pathogen metapopulation.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR601382-2};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 47 family.
CC {ECO:0000256|ARBA:ARBA00007658, ECO:0000256|RuleBase:RU361193}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCI48519.1}.
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DR EMBL; CAIX01000231; CCI48519.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A024GNQ8; -.
DR STRING; 65357.A0A024GNQ8; -.
DR InParanoid; A0A024GNQ8; -.
DR OrthoDB; 942598at2759; -.
DR Proteomes; UP000053237; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004571; F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR044674; EDEM1/2/3.
DR InterPro; IPR001382; Glyco_hydro_47.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR036026; Seven-hairpin_glycosidases.
DR PANTHER; PTHR45679; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR45679:SF2; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3; 1.
DR Pfam; PF01532; Glyco_hydro_47; 1.
DR Pfam; PF02225; PA; 1.
DR PRINTS; PR00747; GLYHDRLASE47.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF48225; Seven-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR601382-2};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycosidase {ECO:0000256|RuleBase:RU361193};
KW Hydrolase {ECO:0000256|RuleBase:RU361193};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601382-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000053237}.
FT DOMAIN 595..685
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT ACT_SITE 123
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 263
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 358
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 380
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT BINDING 465
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-2"
SQ SEQUENCE 726 AA; 82182 MW; 4061ACA57B21ADFE CRC64;
MRLDGFVWLL MYGSPQLYAR EFHSSERIHL KNKAREMFYH GYNNYMEHAF PWDELKPLTC
EGRRWDRRER GDLDQTLGGF SLTLIDSLDM LAILGDHKEF RRAVKLVIQH VTFDRNVTVS
VFESAIRVIG GLLSAHVLAS SDYVGLMPPP EYTNELLELA VDLATRLLPA FDTPTGIPMD
RINLLHGISK HGPFVTCPAA GSVLVEFSYL SRLSKNPIFE QKARIAVLAM WERRSQLDLL
GSSIDVLSGT WTSSHVGIGA GTDSFYEYLL KYHILTGEAS WLDIFNSSYT AVEAHTKFND
LHVEVDMHYG NRRIRYPRVS ALQAFWPGLQ VLAGDVINAV KSHDKLFDLW VKFGAMPELF
DLRGGGAVVE WARASPLRPE LIESTYHLYQ ATRNHKYLKV GRKLLHDIEA VSRVPCGYAA
VKDIYTLEVE DRMDSYFLSE TIKYLYLLFS DDPSVIVPST YIGKTHTVSN VSAFGTTNCF
DGEGYWTRPV KSSEIIFSTE GHILLTAPEL YRRNSSHQMA ILHQCESSTG FENNQVESLS
SRKYSSSGYM PLGLSVRYKN THVGTILASP AKFGQQIINT KLTLEAFFDL EPVGNGCDTI
SPSSLLSERI SGKMVMVYRG NCTFARKALN LEQAGAAGVV IINTARVPYK KYRTQFYLIW
DDRSKIGQNV SIPVLMVLAE DVNRLVQLIK DHELKSLLTV KNHRKHKQSF LEEEDEIVVS
LSSWLW
//