ID A0A024GTV4_9STRA Unreviewed; 4712 AA.
AC A0A024GTV4;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Phosphodiesterase {ECO:0000256|RuleBase:RU363067};
DE EC=3.1.4.- {ECO:0000256|RuleBase:RU363067};
GN ORFNames=BN9_114790 {ECO:0000313|EMBL:CCI49986.1};
OS Albugo candida.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Albuginales; Albuginaceae; Albugo.
OX NCBI_TaxID=65357 {ECO:0000313|EMBL:CCI49986.1, ECO:0000313|Proteomes:UP000053237};
RN [1] {ECO:0000313|EMBL:CCI49986.1, ECO:0000313|Proteomes:UP000053237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ac Nc2 {ECO:0000313|EMBL:CCI49986.1,
RC ECO:0000313|Proteomes:UP000053237};
RA Gardiner A., Kemen E., Schultz-Larsen T., MacLean D., Van Oosterhout C.,
RA Jones J.D.G.;
RT "Recombination and specialization in a pathogen metapopulation.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|RuleBase:RU363067};
CC Note=Binds 2 divalent metal cations per subunit. Site 1 may
CC preferentially bind zinc ions, while site 2 has a preference for
CC magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067};
CC -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family.
CC {ECO:0000256|RuleBase:RU363067}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCI49986.1}.
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DR EMBL; CAIX01000373; CCI49986.1; -; Genomic_DNA.
DR STRING; 65357.A0A024GTV4; -.
DR InParanoid; A0A024GTV4; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000053237; Unassembled WGS sequence.
DR GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 3.30.450.40; -; 3.
DR Gene3D; 1.10.1300.10; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002073; PDEase_catalytic_dom.
DR InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR InterPro; IPR023174; PDEase_CS.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF00233; PDEase_I; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM00065; GAF; 3.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF55781; GAF domain-like; 3.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS00126; PDEASE_I_1; 1.
DR PROSITE; PS51845; PDEASE_I_2; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW cGMP {ECO:0000256|ARBA:ARBA00022535};
KW Hydrolase {ECO:0000256|RuleBase:RU363067};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Metal-binding {ECO:0000256|RuleBase:RU363067};
KW Reference proteome {ECO:0000313|Proteomes:UP000053237};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 780..1142
FT /note="PDEase"
FT /evidence="ECO:0000259|PROSITE:PS51845"
FT DOMAIN 3701..4177
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 4309..4627
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 752..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2300..2319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4600..4621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4689..4712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4602..4621
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4712 AA; 535106 MW; BF73803E4734A56E CRC64;
MQYCNEELDR SRRHDFHEMP SRKRWRLVLL QFSIISWLIK KLLHRHNERV VLSQQYIIDT
LLLKKYSLED SLTIIREQLI SVIDIKDCNL VLRARSSFLV QLHDAVRKNF EVFSSELRMP
DSIEDYDTST SDKPSFCLPL MNADESIQAV AYIAEAHRSI VFSSYFSTKN RSQPNYIERY
LRVLGRILQI IIARYVHAIE MNDNQESAQL NTSLDELHTG ETRNRLNGML RNSLANLTAI
LQEVVRARYC TVFSYDRSKG LQCVYTDHLK WFSLIQYGDE LAQKCANENK IIQHDANAVF
EVISDNMLQK EYSSLCVPIH DITGGVCGVL MQQIGRNEPF WDYTDTEITN RIGQHIGSAL
QIAKSSDHLE TEEKLSSDFI ASLSREIELT PLLHNASKLI SSLFRSKPCR IFLVDSKKST
YHLPVQNVYP NSIGGPTRHF SALVGIIGST IQSGDVLQIS EACTDPRFDA MADGQDDLYM
HSILVSPVRN HFGHFIGAIE IGCKTSAETF HESDENLIRR IAHCLGLTLW NSLRFECAKL
ATRKSDALLA TFQAKSSSNE HVSDVFTAFT NITCKFMSVQ HATIFFVDEL GHTLHSRIDS
RWNAYSIPMG QFLQGKVALS GELEHVPYDA QMHPELDHAY DELAKIKSKS ILCAPIKSRV
GLSMKRKQPG RVKEKVLAVL YVVNKVGFTN GGYFDDGDVE LIKALSFGMA SLVHHRAWEL
MFQPESSTSD ADESAQVANA FLSQYTSAAY NVRRRSSHES RGSSGENTEL GNAPNISKKV
TPGEQPLIAR YKKGTGFFSH YNVKSLPCHD TLCKWGLDPW KLSSTELVDS VVNMFETFEL
RQHFEIPVLT LRRFVMNVKN QYQSVPYHNY FHAFSTLHTV FMMLYAQVKV TAKRVFIEVV
QSCANDPISP TNLRFEQIFA PRDVLAMFIA AYCHDMNHNG RNNEFHIRTS SRIALMYNDH
SVLENMHAAA CFETLRHPGQ NVLATLDETE YHLIRKSIIN AILATDMQNH ANMVALLHEK
FKPGVFQPSD DSHKELLINT IVHSADLSNP TLPHDLHIRW SVCLLQEFNM QYEEEVALGL
SPTSYMNARP NSSEQGQVNL AFIDSCVFPI WSILNSALNG LEGCLQNIQE NRQSELPQMV
RRSQECDAEA HVAGKKDRQN TVTSTDVIWS EFKTYCNQLR HAKNLKDRNK AFNQLQVFMS
SENHRYYVQK WRGWSLLISS VLFTVKEDAK DVFKDLDNSL MKNVGSIAIG KRKAGKIAKI
SKKNAFSIPK MTYWNYLCTL LGDANVAEGP ILHLDANGRD VIKELFVFSG SVLECGVQLM
TTSLQNEEIV ECNTIQQKKK VVTVLTATCW QILKSVSDHR VYCNVLAPSQ VDSVFKIAFK
TLEFTDKNMF TSREPHGRPP CSIQSSFFLS ASQQTNVALI MKKLYKGRCF GIGGQDAVSH
VRFFETWFAS LQYNNIGSVE VLAVTMLQAV TKLLERHWDY GLAMMMISSP GMNIIHFIQR
AWKDTSFRLR GAYLDYLLLF CEALKQYRNG LLPFLAEIGS NEIDDSSLFR EMNTLLSIFL
HPKQLNQYLQ GVDVISRALN LVCGEQETSS ISRTENITSG ELCINSLALQ VEKQSCKFYQ
CTAELCFQHD GLLQRVQSTF EMNGPHAKLD QSAAATGSDN SLPAAAIGNY PLTSARDLLR
TKLQTLFDVK IFIPHAELSG EHVTDNVLPR HPRLKSAGSY IFLLSSIVCR YGDASDCYLD
GNIFFEVLLQ CLDSKTIDVL QFLALLTLLK ALGYLKYRSK IDEGMRLRLW ETLLRSDLPY
AATTDSSMIK NSAGSIVMQL TYACFTLLSP EFITREQNRL WKLPLFALHT KAAMNSNKNR
RVQVKGVGAS ARKESRLQLS VSPLVFISQF IVQFELYEVE EEKECGQAPF TLRNIGTRPQ
TTRERLLATI LFLLDFKSMY ELDFDRQGTT SGDVFIIQSA LSLIVLLGRA FSRQIIHTSP
LMKNLMIPTF LYTMSQSFSD KRKKKTRCSN SVEWTSFGIF VTSEEEEVSR MIHQATWPLP
FEEAHAQEAP LSVVIYREQM RSSDTNGTEG DQLTAYPESN RDTFAPIHPP PWLLDNQHSP
NCIDVEARNK DSMSTKFTNF VPDSDIQTLF TDVVAWIGNR IDVVKSTLEC LQPEDPASLA
QINTTLDMAY VVFVLTNIDS VPAVSIKEQL RQLQQKLVAS IIRNIQPDIL LELLTLNNTA
ALTVQLLFRR LETLFLITKG PNALNTQADV TQSSIRLLAT QLAMQVGALL ESLVTSKKKI
TKSPTKFCAV SKPQISFGWP SQESPSVNRR KSPVSKSFSD THTSIINDVP GECYLASEKE
ADFLDESAET RGGLKQSFIR HDIHVNVRMW ALRLLTNLDI SSAINIIQDV AQELQLTPEA
LIALASFLYR SHPTEQNLES HFLECSESVK RLALFLRLLD CAMEDIEKEA ASTRLDVKDF
FAKDVTIEKK AGDRVFAFYY QAFVALKACL STFEKQKKSL LHFTTQSILP VDLTNMITKM
LECTAQVGSE TRYWTLEVIQ LQVFEISFRL DPEYAAEFPD HCMQHLLHSV PFVRIIAARC
LQSVFYMYPS GGAQIFSTLL QVLDEEYFSS KQSAQTTDGP KHDLPWNNRV MWHLLYVCGS
SDINVLPSAL AVFLWSLRHF SHRSEPGNIY SAAHEWLRSI GNFYGYPSAQ DMMNSHMLQV
WMQWCLKLGV DGSTERPFSI LEALEAFPVY ILSPLNVRTS SEHASIPCIA PRFFLRHISV
ILPVAILVQA RVAHTQGTRI HFKSIQEVYS YLVDDDHNAM KIIGIHCISD SIALAAVLST
FGDRLDNAGQ RKHVADLAAV IINAIKDENT LNDEFSSDQL TCIVAKITQL AMSVYLPESW
ISSGEESTYS TVLIAMVSGH DDRKFWKAAL LKLEEEFLRV PTQMIEKPLD RINLPQIYAC
VWLLLLTTSC DSHSTRAEPT VDCLECLIDQ TKSFWTEQEA LSRFIMHILF TTTHHLLSTL
STTTKHFVKS SHEYTKALDR APVEATSIID SAEQLTRILC TLSEILAQEP ASTHALGRRL
TWMTEHVCRM MQVANDSKYL DKIKANLEAL TLLLVQVAEI SDKTWLNSDS IRSGLSPRLD
ALKVLFEKAK VKNDQRHGMR WGEPPTNHLY QSRPGLFATQ NEDDELLRNI QDAKTLLHSN
LGRSSENIDD ITSITSRLLR SLLHEYTSHA DQDDIISTHL RCIQAQTLGE LGALDPYVFS
LTPDYGQEER VQSWKGMVRQ TAYNGSANHG SNMPLSMHEV MISELVRILF HPHSSSQWIS
PFHTARVLRK VLSTLCRLVS SDCANQAFMN WNCKEPGLKC FVEQLASVTL INWDQECLFF
EHRTGPVHFI WSLPGKSGFD SWITHTTTSI LKVSASLDEK LSSLACDVSI IALQPGLACQ
LFPHILYIIF QKYSKDNQTF KDIVDGLESI CSSHRIQDIE SYPSADRYAV QFLMHSLNFV
REREKREFME MVNVRPGRPS YILRGILAPI DLLRVAEATI HVKMPCSAMQ YVEMWMERTY
GELVNLGRVT PETPGKKNLD RARNILLEAY QFDATNADAM DGFNEKLSTS QRILSHTHGK
DYAKALPLLD AIVQCSHFSG SGQLNNNIES LLYCLRRLGY EHLLGACVNL TSRSTADRSE
NGIKLQVQEY EYEKRWHQLE WDKKSDLAAL MSWHDQEDDK EKVRYRHHCT LFHALRALVK
NDTEQTLGII QESQLAILKL VQFAVCGQEQ VADSHKALLH LQHLKEVYDA TKLLCRTDKE
KSSAHSWEIL LHQWFKRHDR IRGDFDSLES ILRLEETLLK LLIQREWIAI DKQESNARYL
EQQTSDWSSN ALAKIYLLLA CSSRKSKRIA TATKALLFLQ EMDESRRLSF EHMIQWRLEK
SKLSWAQRDH RSAIQTAQVV LHQIDASSEP RHTLLVNVLT TLGSWLASQR SINSHVIINE
YFLRATKIAD CALTESGSFR VLVKAYRALG NYMADMYQQV QTRVSSNEWL AGKRVAEARQ
RELRACLDME ESKQKESRAH IHTLTKEIEF DHKERAKVES SVDNFLIGAL QNYSKALQHT
YIKGELAMIF RLVSLWFSNN HKSAVNETIH LVAESIPSYK FVPLSYQIIS RIGSEPNGIG
TKSQEFTFER VLNELVMKLA EQHPHHVLIH LIALRNSADV EGRGAAEFRV NAGDAKAQVA
EEYMNKLYAT KQGDLLRGLH LVSQAYGTLA LFDTREEQKK SRKISLSKVK SQVPTQSRPH
GKLVLFDHCT RYFLQKNQNV HNMPAVLTDS IEPRADMDYS DIARIRSFDP NFTVTETGIH
RPKIIYCFGS DGRRYKQLVK GMDDTRQDLV IEQMFVTMNT FLQEDPATRK RKLRIRTYKV
VPLSPISGVL EWVDSTLPWG SYLVGRTGKK NSAHERYHPH EWKHMECRNH LQNSVDKLAA
YQEIEANFTP VFHHFFLETY PDPAIWYQCR LAYTKSVAVN SIVGYVVGIG DRHSQNILIH
KDSAELVHID FGVVFDQGLA LLTPETIPFR LTRDIVDGMG ATGCDGVFTH CAQETMRLLR
NKSSSVITIL EVFVYDPLYR WTISPLKALQ LQCNRPMISE RPKSSSVHHT KQDAKRNHND
AAARALIRVK QKLEGYEDPN AIKEHKMPTI IDVAHKTAAA GLIGLTIYGL VDVSRGFSIL
VKRNIDRKHA AKSSEMEKNA HSPSTAGPGP EP
//
