ID A0A024HLQ4_PSEKB Unreviewed; 391 AA.
AC A0A024HLQ4;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:CDF85980.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:CDF85980.1};
GN Name=thlA {ECO:0000313|EMBL:CDF85980.1};
GN ORFNames=PKB_4656 {ECO:0000313|EMBL:CDF85980.1};
OS Pseudomonas knackmussii (strain DSM 6978 / LMG 23759 / B13).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1301098 {ECO:0000313|EMBL:CDF85980.1, ECO:0000313|Proteomes:UP000025241};
RN [1] {ECO:0000313|EMBL:CDF85980.1, ECO:0000313|Proteomes:UP000025241}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B13 {ECO:0000313|EMBL:CDF85980.1,
RC ECO:0000313|Proteomes:UP000025241};
RA Linke B.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDF85980.1, ECO:0000313|Proteomes:UP000025241}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B13 {ECO:0000313|EMBL:CDF85980.1,
RC ECO:0000313|Proteomes:UP000025241};
RA Miyazaki R., Bertelli C., Falquet L., Robinson-Rechavi M., Gharib W.,
RA Roy S., Van der Meer J.R.;
RT "Genome sequence of the 3-chlorobenzoate degrading bacterium Pseudomonas
RT knackmussii B13 shows multiple evidence for horizontal gene transfer.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; HG322950; CDF85980.1; -; Genomic_DNA.
DR RefSeq; WP_043254816.1; NZ_HG322950.1.
DR AlphaFoldDB; A0A024HLQ4; -.
DR STRING; 1301098.PKB_4656; -.
DR KEGG; pkc:PKB_4656; -.
DR PATRIC; fig|1301098.3.peg.4645; -.
DR eggNOG; COG0183; Bacteria.
DR HOGENOM; CLU_031026_0_1_6; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000025241; Chromosome.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF144; ACYL-COA THIOLASE-RELATED; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:CDF85980.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000025241};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:CDF85980.1}.
FT DOMAIN 4..260
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 268..389
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 88
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 347
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 377
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 391 AA; 40570 MW; 660AF5FC54AB88D1 CRC64;
MSEIVIVSGA RTPMGGFQGS LAAVSAVDLG AIAIREAVAR AGIQASDVEE VIMGCVLPAG
LKQGPARQAA LNAGLPSAAG CTTINKLCGS GMKAVMLAHD LLKAGTNQVM IAGGMESMSN
APYVLEKART GLRMGHGEIK DHMFLDGLED ARTGRLMGSF AQETADQYGV TREEMDAYAI
ESLKRAQAAI KDGSLASEIV PVTVTTRKGE VVVKDDEQPL TANLDKIPGL KPAFKKDGTI
TAANASSISD GASALVLMTA EEAARRGLKP LAKIVGHATQ SQDPSEFTLA PIGAMTNLFK
KTGWNKDDVD LFEINEAFAM VTMLAMREHG LDHAKVNVYG GACAQGHPVG STGSRIIITL
INALQKKGGK RGVASLCIGG GEATAVAIEL L
//
