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Database: UniProt
Entry: A0A024JQD7_9MYCO
LinkDB: A0A024JQD7_9MYCO
Original site: A0A024JQD7_9MYCO 
ID   A0A024JQD7_9MYCO        Unreviewed;       532 AA.
AC   A0A024JQD7;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   30-AUG-2017, entry version 27.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:CDO86065.1};
GN   ORFNames=BN973_00403 {ECO:0000313|EMBL:CDO86065.1};
OS   Mycobacterium triplex.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=47839 {ECO:0000313|EMBL:CDO86065.1, ECO:0000313|Proteomes:UP000028880};
RN   [1] {ECO:0000313|EMBL:CDO86065.1, ECO:0000313|Proteomes:UP000028880}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44626 {ECO:0000313|EMBL:CDO86065.1,
RC   ECO:0000313|Proteomes:UP000028880};
RX   PubMed=24874681; DOI=10.1128/genomeA.00499-14;
RA   Sassi M., Croce O., Robert C., Raoult D., Drancourt M.;
RT   "Draft Genome Sequence of Mycobacterium triplex DSM 44626.";
RL   Genome Announc. Announc.2:e00499-e00414(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; HG964446; CDO86065.1; -; Genomic_DNA.
DR   EnsemblBacteria; CDO86065; CDO86065; BN973_00403.
DR   Proteomes; UP000028880; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028880};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028880}.
FT   DOMAIN      225    353       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      437    505       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     233    240       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   532 AA;  59189 MW;  14CD1857BDBFA057 CRC64;
     MYNYVDSCFV AKRGFTSTSD QGDASLTDDS GSGFTTVWNA VVSELNGDSD ADGAAGNRTT
     LVTPLTPQQR AWLNLVQPLT IVEGFALLSV PSSFVQNEIE RHLRTPITDA LSRRLGQQVQ
     LGVRIAPPTD DADETQFAQG DTFADDIDLE TSSDTDEADD NGEAIGVEQS WPNYFTERSH
     GGDPAAAAGG TSLNRRYTFE TFVIGASNRF AHAAALAIAE APARAYNPLF IWGESGLGKT
     HLLHAAGNYA QRLFPGMRVK YVSTEEFTND FINSLRDDRK VAFKRSYRDV DVLLVDDIQF
     IEGKEGIQEE FFHTFNTLHN ANKQIVISSD RPPKQLATLE DRLRTRFEWG LITDVQPPEL
     ETRIAILRKK AQMERLAVPD DVLELIASSI ERNIRELEGA LIRVTAFASL NKTPIDKSLA
     EIVLRDLIAD ASTMQISAAT IMAATAEYFD TTVEELRGPG KTRALAQSRQ IAMYLCRELT
     DLSLPKIGQA FGRDHTTVMY AQRKILSEMA ERREVFDHVK ELTTRIRQRS KR
//
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