ID A0A024TYU3_9STRA Unreviewed; 3111 AA.
AC A0A024TYU3;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=B30.2/SPRY domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=H310_08053 {ECO:0000313|EMBL:ETV99325.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETV99325.1};
RN [1] {ECO:0000313|EMBL:ETV99325.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETV99325.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI913967; ETV99325.1; -; Genomic_DNA.
DR RefSeq; XP_008871881.1; XM_008873659.1.
DR EnsemblFungi; H310_08053-t26_2; H310_08053-t26_2-p1; H310_08053.
DR EnsemblProtists; ETV99325; ETV99325; H310_08053.
DR GeneID; 20085103; -.
DR VEuPathDB; FungiDB:H310_08053; -.
DR OrthoDB; 49176at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11709; SPRY; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.720.50; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042469; HECTD3.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR004170; WWE-dom.
DR InterPro; IPR037197; WWE_dom_sf.
DR PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF01135; PCMT; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF02825; WWE; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR SUPFAM; SSF117839; WWE domain; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50918; WWE; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Signal {ECO:0000256|SAM:SignalP};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..3111
FT /note="B30.2/SPRY domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001537791"
FT DOMAIN 1276..1479
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 2334..2421
FT /note="WWE"
FT /evidence="ECO:0000259|PROSITE:PS50918"
FT DOMAIN 2748..3106
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 3064
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 3111 AA; 353356 MW; DB0BFA86A07EF18D CRC64;
MRWKGAMAVL LSLGWTVNTT GYYHLEYLAV PSAPQNLNDA ADLLVKYIRL CEQRHQQLTQ
THHLLHLEST TAFSTTKQDK TTTASGLQQQ VEFHCPLTHQ QFTSSKDLSL HAARLEPWLK
CMVYCRMKKL FWYSPYSVQP QGNLHYPSYT SCRLEVQASS DVLWIRHPFY LYHACLRHMI
TGANGKPGDI AWRDEDDFLF GLPSVHGEVH FTHARVFPSE VAVVHALVPC VVDDNEVAAP
SQAFLQTLIQ CQECPWLVRL GPVQSRSLER IQLERKVVGL ALVVSGLLPA ATTNMDHPAW
IRLRLEYQTF HQWLHQQCQH PSNDTLGHLE LWVTFLLQMF ADAPLTDLWA TGDVFDYVIH
QVFTFFKRIH DIPLTVAIQQ RMLRHRRAAW LQMIGLVVLE AHLQACPVLP SCQHIAIESM
AAIFKHKNAG AQSIRYGRHW TKLLQATHGW SRECDAWIVE GLYRLWRQPK PVPQTFAVLD
RPAATGGLES IFDADITPEA WTTALFLTLD CIDTKSVVTL LVDQLHKWLV QAKDECVLRG
HRLVSLCMER CSTSNDVAFL PSLPTVCTLM CTKLHLFSHR TQEHLVHGLQ TLLPLIRPTP
ILLEFTVLLA TMGQDPLAVG GEPYLITEVT DIESTKVVLK PTSAYSHTLP PLALQAAKAA
MVAWSLQSTI STWLISAAND VLSSGDNLSD RSERKTGVGH LLGLGSVMLA AQDCSKFVLG
HSLHMSRSDI VPVTDGILLS LQRGNTLRAT CRCLFRSKCA ATPFFIVQCT AGLLEFPCDD
HGTFTRTLVT PNVLSLVERA ASITPSTVVT NWFFKVWLRS LDSPRDDTIS YLLDVALQPA
SLSIPPHALV SPQTALQPHT YWRVEEMYRY AVRELGRLHL LETVHADHPL LCGPFYAHER
SKEASTIQRH RHGHRLPTAL TPSRILTRDN LKRIAAIDSN EACNPTTVGN AVDLAKLCDM
GYSPSVCAYV LRHYQQNTQG ALQWLVNDQN YDDIRQIELM HQPPSRVGFG EALTPSATFF
RLNADIKESL LMSCSTSREL LNTLRQVPRE SFVPRLYEKE VEDDHAIPHP LGYTLPSMYQ
SLRVLEALKL EPGVRILDIG TGSGYFVTLL ARLMGDNASI TSWEQDADRL AYAYIYMAQS
VQDGHNVIYP KFMETIRFEV CNAFLNDHAD ATFDRVHAGA SCPRESVNLL LQYVALHGIL
VVPIDGTLCR IHKTQPTNDW MHLPVEPLGA YSIESLTPPS LQVLSASPSD ATNCQRRYGL
HGFEEETRTK PLRVLTMDED MVEIPTVPYP LQVNMLFQVT PLTKSRMYQQ GQSNTGLVVT
RVGPTPVQLK ELSVSNRGSF GTACANVYVR GGGVWFFEVR IGTSKVIQIG WILPGFDPNP
ESGLGVGDDK YSYAYDGRRK KKWHNGMSDD YWKQSCKAGD VVGCLLDLDQ GNMSFLLNGT
HLGIAYTDLP RDFSMGGYSP ACSMDGGESV WFNFGVKPFL YPPSQHFCPL ADFVYLPLID
IPTTVQSSTI FVAKRVHADA VAATTIDDPS VTILIPRNRI APLDHHLALF LYHESTYNQA
RSGSWEQLCT ELQRSLRISM ARSFLAAHMS SLSPRDLMAY LSWASEFPVI QSDQFKLSRH
QIPWLVDALD RQLHEAADTM VIEESRHPIS HRLLAVTPVV IMALKTLRTS LLDMENTMEK
GNSKGAMVHL QRATETLLSR TEREPGDHFQ RCRSQLESAY QRIRSVSNEF TFADPSTYTR
RPMLEKVVHL KQALELFEAQ VSFPSRIPIE AIEAKYVGLP EALSLKVEFD PRTLRTNWKL
LFFKDAACQQ RWPYVLSRDG FAPFIIPSNH FYYTFVPDTT KTHLTPEWGY AFRVTPYILH
PQHCTPTWSL WTAVQAQPQL QDMLIQSNDA ASWLQSILRY IRTPAAPEKV HVLSTLVLCL
HRNRMRLPAD LQPHLSEFLW YLHPELNFVY RTSIKWRLHS NPYFQTLLQT VTTIASLAER
RIQRVGIHTF GYHAEMHMWH KELIETVQGL DAMHPATWQP IISKQYNPLH MLKQLFKQFE
ASIKSDVQRW HKNRRELWIR QVDQAYHPAL LSHCLYVFND TLLPVCVASR ECGWAAERNK
WLRHLHAACT VGDIAMQLMV LAGFIDVDSH SSTWPCQSYD WRKAVMNLTK TDLSEDGQLE
VSGQWTDGHV VLENDLATTS LNRIFEDSPK LFRVRQAENV HVIGAFGYKR TLIRKIQFRL
RKTFNNTPCT AGMVFVFPEY PTPEDMMKIQ HYDHFTSEKY QSYVLKMRRR AMVPIPGDPV
AYFDVTSPHY CQGNTVTVVP DFALVGQYVV VKLLRCYNIR VMEDLADVIK RQEDHHAPTN
VYYNVNSVYL WCYKPHEEWL IYPSAIEYMI ESKYQAYCQG DIVSHGEYVV AGEDVVLDFQ
NMVQYTPTDQ FSNPVTCRIK RVQVTIDMKI KLAAPPSMEV EYMGFFGLQE TAADEAYNTW
KVKFQTLAMT AQHAQLNSPT TQLYRVLSEK SPVHNFPSLS ASISTYVLYG EIVSITARNG
RWGCIANSEA WCLLDTHQPS FFPISQARAA AHGTVPWLPD QPVHCVAPNG EAYSGMFQIG
ASREVDEELV HMVNKLRETS GRCVTNLMVS DVYASLHGKH KDYPYLSIFP IPAITGRLDV
LRAINARLSQ CLMFIGIGLK LKEPDWLSGV VLKAKSCLFL ETKMHVWKKI WSESYSMERS
SEVVTINRHL AFKARDTLRD CANVLQDDLA VYSPTVFVQL WRELHRTSPG LLRRSDGKSW
FTKFKGEPSI DDGGLYRETT ATTCYELNNG LLPLFIPCSN GKHTQGLNQN TLVPNSSCTK
WHECCEWLQF VGVLMGIATQ NLEEVFPIQL APPIWKLLVA EPLTPHDFHQ FDVATAQTLR
YLRHADFDSD DMFASIFPDQ TFTCLNEQDE VVELVPHGAT IPVTLGNRLE YADALESYRL
HQFDEAVGFI RKGLESIVQV DLLPMFTWSE LELLVCGRPT LNLALLRKKT EYSPDMDMQD
ALVERFWRTL AGFTSEEQQL FLQFVWGRTR LPFSEVDFGS YTFKLVRHMS PSNPDNYLPV
AHTCFFQLEL PNYSSAAIMR SKLLYAMNHC TSIVDEEQAA HQLEIALWDS S
//
