ID   A0A024UN63_9STRA        Unreviewed;       370 AA.
AC   A0A024UN63;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Dynein regulatory complex protein 10 {ECO:0000256|ARBA:ARBA00021752};
DE   AltName: Full=IQ domain-containing protein D {ECO:0000256|ARBA:ARBA00032180};
GN   ORFNames=H310_01847 {ECO:0000313|EMBL:ETW07292.1};
OS   Aphanomyces invadans.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Aphanomyces.
OX   NCBI_TaxID=157072 {ECO:0000313|EMBL:ETW07292.1};
RN   [1] {ECO:0000313|EMBL:ETW07292.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NJM9701 {ECO:0000313|EMBL:ETW07292.1};
RG   The Broad Institute Genomics Platform;
RA   Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA   Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA   Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC       key regulator of ciliary/flagellar motility which maintains the
CC       alignment and integrity of the distal axoneme and regulates microtubule
CC       sliding in motile axonemes. {ECO:0000256|ARBA:ARBA00003029}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000256|ARBA:ARBA00004611}.
CC   -!- SIMILARITY: Belongs to the DRC10 family.
CC       {ECO:0000256|ARBA:ARBA00009071}.
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DR   EMBL; KI913954; ETW07292.1; -; Genomic_DNA.
DR   RefSeq; XP_008863385.1; XM_008865163.1.
DR   AlphaFoldDB; A0A024UN63; -.
DR   STRING; 157072.A0A024UN63; -.
DR   EnsemblFungi; H310_01847-t26_1; H310_01847-t26_1-p1; H310_01847.
DR   EnsemblProtists; ETW07292; ETW07292; H310_01847.
DR   GeneID; 20078897; -.
DR   VEuPathDB; FungiDB:H310_01847; -.
DR   eggNOG; ENOG502QQS9; Eukaryota.
DR   OrthoDB; 50940at2759; -.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.190; -; 1.
DR   InterPro; IPR042815; DRC10.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   PANTHER; PTHR31598:SF1; DYNEIN REGULATORY COMPLEX PROTEIN 10; 1.
DR   PANTHER; PTHR31598; IQ DOMAIN-CONTAINING PROTEIN D; 1.
DR   Pfam; PF00612; IQ; 1.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212}.
FT   COILED          148..240
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          270..335
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   370 AA;  43052 MW;  A2A3A9552A080162 CRC64;
     MNKLTNVESQ RVMSVLGDML DRLNYLTYVP LKRDYHLIGR LHENGVSMVG DQVEQLWQLD
     DGLENMDEPG ARRDDMLAKI KLTVRSICRH MRENPVVVTT FFGTASSTPV DVGDEMMALI
     KFLSELTDLM YSQLSKTVED ETSKRDMMEN IFNRRKQAED DLVELRDKLN DMRKTKEDDI
     SHLDIQLQKL KGELATINKT TANELQLIQT QVKETLEKAY EQQSIEMQAL QETHTQHEQL
     LQKNTTEHRD IEDALRKAKC KIAIEVASTV ERYDQDMLAV TAEIDALQDK YAAELKEFQA
     LSDHFVKIDE EQLRIEEEER ILEAIREEER REIQKLHDAA IRIQSVWRGY VVRREFAAKK
     KKGGKKGKKK
//