ID A0A024UPP6_9STRA Unreviewed; 4251 AA.
AC A0A024UPP6;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0000256|ARBA:ARBA00023902};
GN ORFNames=H310_00980 {ECO:0000313|EMBL:ETW08386.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETW08386.1};
RN [1] {ECO:0000313|EMBL:ETW08386.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETW08386.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI913953; ETW08386.1; -; Genomic_DNA.
DR RefSeq; XP_008862191.1; XM_008863969.1.
DR STRING; 157072.A0A024UPP6; -.
DR EnsemblFungi; H310_00980-t26_1; H310_00980-t26_1-p1; H310_00980.
DR EnsemblProtists; ETW08386; ETW08386; H310_00980.
DR GeneID; 20078030; -.
DR VEuPathDB; FungiDB:H310_00980; -.
DR eggNOG; KOG3595; Eukaryota.
DR OrthoDB; 312195at2759; -.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR049400; DYNC2H1_AAA_dom.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF352; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1678..1815
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1969..2191
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2272..2420
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 671..705
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2877..2929
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3058..3085
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3376..3403
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4251 AA; 478952 MW; 9FCDCD1E0D1BFB92 CRC64;
MGREGEDVRR SYVLQLLESM WRDKGADVNQ IHDDKALASF LDDTACGLLQ VRLGADKKMS
LSTSVQWDDN NNAAEGVSQA VLLVKTLPQP LTSDNLSTNI QVSSMTNSPL YSLFQSVNKI
YAPLLLNGGS GSLSQKLKDV LLELDAGLQT TVREKGDEKG GDISLFGIVT IQDEVQFWEN
HMTGRDRERS SKFTSSLDAI QSRYGTLDAL SFDDMSELLD DTNNTVDDIW RADLEGAAQY
PQKRMVHFFG LVDHALNSFI VLKAGALNVW KGPYHAVQVA LTQSILLCEK WIEHMEQLTG
TFWPSYAEHP WDGRPHNDVI LPPLMKRLEE VLRVRTTFEE LMSLCNDKAL NASCFDVFDR
VQPLQYNPYT VKAWQSTVDE FEALLAPMEA QAGTNLRERM ASVLSKPTTA LRYLQQYRAL
LKRPAISRVL SGERDTLLAQ ILAQIDQLGS DFETRANEDA PCGKNLSSKV NYIVWGTMLT
NRITTIMTLA TTVLEDLPGF PGLRKAGDQM LQKIHGTITE HIRSWQDEVE ENLSSTESSL
KLSGRLMEID KSGLLTVNYS EFLVTLLRDV RQLTELNATD PGSKHHPPWV PPRVLQVALE
AEKYYRYGVT LKKVANFYNN MESQIIDEQK PMLLDALVAF EDIVRRPGVK QSSTSTKTSK
PKQVDVTWNN LDECEEYVRQ LQQAADALSV ENRKLRRAHD KVAEELVVLM DVDLLRYPEK
WKDKFDSIKA FVTTSIKKYD ATLTKKWLLF WDHQLYKVLE AGYQIGLESL NENLPEIKVE
LVFPQRGPLA FKPPIEDLRA NYYKAMKKFI GRPAMFKGFA NPSVFASMCD MNAANIVQVY
KNGELLFAKL EAVTKDYDAW TYLTCATDLD AMLDSMLTDV ADWDMNLKTL KAKRKDSDKI
PDFVKVDCVS VSLVPFKSSL DEYLSRLQDS LLLSLRKSLT GHLKHVEEFL DTSMDKLNKR
PHSIEEIGLA KNEWKVIDGQ KGTFQALVQK AEKKKTLLLS SAGGSIDTSD VVFRLSQIPS
KWENFDIALE AFNEMIEEQR ESLKGDIETK IIECNQEIEK FSQRWNTLKP TEVSTWDDSS
VNKIYDAIVE WRDQFNDIVN RSKVLVDNCT TFQMPLPQFD GVPALEADIT RVEVNWSLYK
EYNAEIDAMA KNDWITFREK IFDLADVAAK WADKLKAMEH TGVVDRILDH CGHIKRAMPT
LKLCRGDPFK EEHWTQLFHK LGLAKGVSLV QLTVGHFLQC LDVLEAQATL QFVKVLHARA
QGEVTIRDAL QELRAWTQTA ELSLLQHEQD GKTCCIIKDW KDITLQLGDN QSLLASLKES
QFFKPFADQA SQFETKMALL DQCLVQLNII QRKWVYLEPI FGKGALPSEA TRFKRVDDEF
RDIMGSVETD PKLFNLADDM LFPQLQDRLT TMVDQLERCQ KALADFLEEK RSRFPRFYFI
GDEDLLEILG QSQNPAVIQT HLKKLYQGIH RVEFSEKKDQ IVAMCSSAQE KVPLNSPVTI
TSAVEEWLEA LTAEMRKTLK LLVVKATNSA SPDYAEYPSQ VLCLAEQIRF NSQCEAAIKN
GTVPELKATL QDTLRELTSL DLSQEPLMHL KVKALVLDLV HHIDVCEQLV NTRSLTDWQW
QKQLRFYLDK SHQCVIKMND AVFNYTYEYQ GNAPKLVHTP LTDKCYLTLT QGMHMGFGGN
PYGPAGTGKT ESVKALGGQF GRQVLVFNCD EGIDFQSMGR IFIGLVKCGA WGCFDEFNRL
KEDQLSAISQ QIQLIQDAIK NHVTSITLLH RHVDVDFNAG IFVTLNPAGK GYGGRSKLPD
NLKALFRPVA MGRPDNNLIA EVVLSSEGFS EAKDIASKVV SLYTLSRQLL TPQQHYDWGL
RALKAVLSTA GKLLQLAKKQ VSGRMTGAQE TEILIKAVRI NTLSKLTFGD SQRFLALIGD
VFPGIESADI SGGDLEAAIR DVMEKKPFCC QVDDIQIRKM LQLKESLDQR MGCVVVGPSG
SGKSTVWQVL QMAMVQCGQL VKTYVMNPKS MPRERLLGHM DLDTREWHDG VLTDAARKVV
KEPETTRSWI VCDGDVDPEW IESLNSVLDD NHLLTLPNGE RINFGPNVNF IFETNDLRFA
SPATISRMGM IFLSDEDMDM KRLVTQWLKT QPDSANLSKW IDELFVLAMD EIAKFDKTVA
TTTVGTIMNG LSHVSGATTR SEFVVALIRG LGANLSLAHR AVFAKSVFLF SNERPPDISA
PLDCFCSGST FTAYETKRTT YDGNSPTVTA TSVIQTISMQ RGLHTVAPWV DRMSPFILVG
PEGAGKNMLI RQAFSAVKGA SFSVLHCNAQ TTADHVIAKI AQSCSLFSTN KGRVYRPRDG
DRLVLYLKDI NLPKPDQYDT CMLIAFLQQL ITFEGFYDPN LEFLGIERIQ IVASMNAATT
VGRHVLSTRF TAIVRVAYMD YPTGDELTAV YSTFLEAVSA LQEAPHREKL ARSMVELYES
IRSKFSVDDH RHYLFTPRDL TRWTFGLLRY DLSGEEVLDV LAYEARRLFR DRLVDADSKA
KFDSALNTIL KTQWRHHAKL QDAYFTSLGQ KRPDDELALV PLRRMATDDF SHVVAQGMVL
YEREEKELHM LLFDEILDHV AIVDRVLSEA GGSMLLIGQS GVGRRTATTL IAHMLGYKLF
TPNLTRNYNS GEFKVDLKTV LLSAGVEGQH TVLYLEDHHF VEDAILELTN SLLSAGEVPG
LYTHEELEPL LGPLKEKMME STIAYRTVYE FFVARVQTFL HIVLGMDSRH GQFVRRCESN
PALYTRATIV WMGAWSAASL KKIPEMLLTS SELLHDEVQK VHLLNMVHLI YESVQADGAT
PREFISFLQT WQVLYTEKSK QLVTEVKHLK SGLSKLVEAS TTVDDLSRSA GIKKKELSAA
QVSADEAMDE IKRALDRASG NRREVEDLKK QLAKAEEATN ARKREIEDEL SDITPVLESA
KQAVGNIKSD NINEIRSLKM PPEPIHDVLS AVLMLLGIQD TSWNSMKKFL GNRGVKEDIQ
NYDTRRITPD ISKAVTKLLK AKSASFEHEN IYRVSVAAAP LAAWVKANMK YSIVIAKIEP
LEADLAEAKR SLEASQARLL SCESELKAID VKVDEMKHLF GEKTKEAEIL RVGLERAEST
LQKAQGLLGK LGGEQTRWSA QVKELETRVV ELPMKLLMAS GFTIFLGQCS ETKRMAVSKT
WDAAMDSATT FEYRKLMSSE SELLTWKSMG LPADNLSMEN GLVVHYTNDR TPFIIDPANA
ATGWLQAHLA KDTTRPLSVV QSQEPRFVSF VEQAVRFGKT LVVLEVDYVE PYLFPLIRRD
LTHQGPRFVV HLGDKDIDYN DNFRMVLVTR NPDPELPPDA RAIVNVVNFT VTKSGLEGQL
LGVTIQNEQP ELEAQKSELL RSEEEFKVQL AALEKQLLEA LATSEGDILD NTTLIESLTR
TKATSADIES ALKKSAVKSE ELDEQRAIYA PFARDGARLF FLVKALHSVN HMYRFSLASF
IALFRATLTA KMDVSNVKDR IMRLSPMLET KVLMFVGRSL FKEHRPMFGL HLIHGMHPDA
FEDNEWEFFV GDLLSDIKKE SALPDWVAPD RRDSYTLFVD TFPKLASQLK FDSSDVWLRW
SKAIDCEVAY HQKVDKVLSA FQRVLLVQAL RPDRLQSAIH AFICTILKVK TLTPPSLDLK
DLCMTEASNV TPVLLITTAG ADPSKELEEV ATEIVGRDHY FEVAMGGGQQ EKALALLRST
ADNGEWLCLQ NLHLVVAWLV VLEKELNGLT PHRKFRLWCT TESHDAFPLI LLEQSLKVTF
ESPPGLKKNL QRTYATFQID GPTTPQRMQL LFLLAFFHSL LQERRTYMPQ GWTKFYEFSF
GDLRAGLNVM ESLSQAKDMD WDTIHGLMEN AIYGGRIDNP YDLRVLRCYL QMYFAHDVLN
GKTSLCKGVK MPSTDQRDDF TAVIDHLPDH DPPRTFGLPD NIERSVQRTA SSAVIAQLRT
LTSSEQASSK FDREKWRVLL GPLIENWGKL TSSFNLDHPA STSGGIPKDK VLTPVEAFVA
MENAAATDLA WTVNQSLQSL KKVIYGTGLL TPAIQTIAAA LLVGQVPSEW SNRWEASEVV
QVWLRSLALR KRALNEWKED CAKGTLLSRP LDLSDVLQPG TFLNALRQQA ARALKCSMDG
MKLMSCWEKD KTTSGTTEWF AIGGMLLQGA SFEGGTLQEP TSDGQELISV PTCYVAYTRE
EEREPYAKDT FIKVPLYYST SRERMLVEIS LPVSGDPSRW IIGGVALFLG E
//
