UniProt: A0A024USU1

Database: UniProt
Entry: A0A024USU1_9STRA

LinkDB:  A0A024USU1_9STRA 
Original site:  A0A024USU1_9STRA

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Ontology (8)   
   GO (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (15)   
   InterPro (10)   
   Pfam (3)   
   PROSITE (1)   
   SMART (1)   
All databases (27)   

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ID   A0A024USU1_9STRA        Unreviewed;      1050 AA.
AC   A0A024USU1;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=H310_01455 {ECO:0000313|EMBL:ETW08977.1};
OS   Aphanomyces invadans.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Aphanomyces.
OX   NCBI_TaxID=157072 {ECO:0000313|EMBL:ETW08977.1};
RN   [1] {ECO:0000313|EMBL:ETW08977.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NJM9701 {ECO:0000313|EMBL:ETW08977.1};
RG   The Broad Institute Genomics Platform;
RA   Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA   Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA   Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966,
CC         ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KI913953; ETW08977.1; -; Genomic_DNA.
DR   RefSeq; XP_008862782.1; XM_008864560.1.
DR   AlphaFoldDB; A0A024USU1; -.
DR   STRING; 157072.A0A024USU1; -.
DR   EnsemblFungi; H310_01455-t26_1; H310_01455-t26_1-p1; H310_01455.
DR   EnsemblProtists; ETW08977; ETW08977; H310_01455.
DR   GeneID; 20078505; -.
DR   VEuPathDB; FungiDB:H310_01455; -.
DR   eggNOG; KOG0969; Eukaryota.
DR   OrthoDB; 211439at2759; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd05777; DNA_polB_delta_exo; 1.
DR   CDD; cd05533; POLBc_delta; 1.
DR   Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR   Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR   Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   NCBIfam; TIGR00592; pol2; 1.
DR   PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR   PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|RuleBase:RU000442};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU000442};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000442}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU000442};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN          134..420
FT                   /note="DNA-directed DNA polymerase family B exonuclease"
FT                   /evidence="ECO:0000259|Pfam:PF03104"
FT   DOMAIN          484..918
FT                   /note="DNA-directed DNA polymerase family B
FT                   multifunctional"
FT                   /evidence="ECO:0000259|Pfam:PF00136"
FT   DOMAIN          959..1029
FT                   /note="C4-type zinc-finger of DNA polymerase delta"
FT                   /evidence="ECO:0000259|Pfam:PF14260"
SQ   SEQUENCE   1050 AA;  117503 MW;  99B90DFE79492C34 CRC64;
     MEPPAKKSRV LRTHASTWPR TTLPSLNAAE HDIRFQWIDI SMYDGEPLAV NPYSRTQPIP
     GPRTGSSSII RLTGVTEDGH SIMAHIHGFV PYFYASCPDG LKPSDCNIVR EALDAAAKKN
     PSDAPAVQLV EIVEDKMSLY GYQFDKKVRL IKIYLSLPNF VPKLRTALES GITIPGYGTR
     SYQTYESNVP YILRFMIDQE IQGCNWVELP AATYRFRTPE KQLSLCQMEV DIVYLNLVSH
     APVGAWGKLA PLRILSFDIE CMGRTGQFPD ADKDPVIQIA NVVWEQGAEH PVTRNVFVLG
     TCKPIVGAHV MEFESEGDML EAWASFVRQV DPDILTGYNI DNFDVPYLIN RGKALKLTPQ
     YHCWGRLKNT PNHMEKKAFQ SAQYGKSDNM RTTMHGRTSF DMLPIIRRNQ QLSSYSLNSV
     CAQFLGQQKE DVPHGIISDL QRGTDDDRHR LAVYCLKDAV LPLTLLQKLS YLVNYIEMAR
     VTGVPLDFLI DRGQQIKVYS MLLRKCRGAG LVVPNLPRAG GGDDIGYEGA TVIEPVKAYY
     TVPIATLDFA SLYPSIMQGY NLCYSTLVAP SDINKLPVDA YQTSPSGDVF VRSATKKGIL
     PLILEELLSA RKQAKRDMAT APDAMSKAVQ NGRQLALKVS ANSVYGFTGA NVGQLPCIPI
     ASSVTAYGRD LLLRTREEVE KVFTIENGYK NNAEVIYGDT DSVMVKFGVE TVAEAMPLAE
     EAAKLVSDIF PKPIKLEFEK VYYPYLLMNK KRYAGLLWTK AEKYDKLDTK GLETVRRDNC
     LLVRRMVESC LKKILIERNV DAAISYTKHI ISELLQNKID ISLLVITKGL SKSTDSDDYK
     VKQAHTELAA RMKKRDPGSA PVLGERVAYV IIDKGKNVPL YDKAEDPVYA LTNNIPIDCD
     YYMSNQLQNP IERIFEPIIG LSKVKSDLLA GDHTRKRSKP GLVQNSGGMM NFAVKKQKCL
     GCKAPLGGDQ ALCASCIEQE AQVYSKQLSV VVAAEQQFAR LWTQCQNCQG SLHQDVLCTS
     RDCPIFYKRI KVQKELGEAQ LALERFKYEW
//

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