ID A0A024UV83_9STRA Unreviewed; 1648 AA.
AC A0A024UV83;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=EF-hand domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=H310_00298 {ECO:0000313|EMBL:ETW09842.1};
OS Aphanomyces invadans.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Aphanomyces.
OX NCBI_TaxID=157072 {ECO:0000313|EMBL:ETW09842.1};
RN [1] {ECO:0000313|EMBL:ETW09842.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NJM9701 {ECO:0000313|EMBL:ETW09842.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Aphanomyces invadans NJM9701.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; KI913952; ETW09842.1; -; Genomic_DNA.
DR RefSeq; XP_008861253.1; XM_008863031.1.
DR EnsemblFungi; H310_00298-t26_2; H310_00298-t26_2-p1; H310_00298.
DR EnsemblProtists; ETW09842; ETW09842; H310_00298.
DR GeneID; 20077348; -.
DR VEuPathDB; FungiDB:H310_00298; -.
DR OrthoDB; 297674at2759; -.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF62; SODIUM CHANNEL PROTEIN 60E; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602077-1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 246..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 901..921
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 933..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 998..1016
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1165..1187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1245..1263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1275..1300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1358..1380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1448..1469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 109..473
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 539..782
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 860..1193
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1241..1474
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1488..1523
FT /note="Voltage-dependent L-type calcium channel IQ-
FT associated"
FT /evidence="ECO:0000259|Pfam:PF16905"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1137
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1648 AA; 184414 MW; CB5173F5522C5E3E CRC64;
MAPTRPNEAS GPSITKVQVR PSMPTTSSPT MAGTKQATPP KLGALVRSNS VKEMMARAAK
SKMMHAKLEA RLGGTKRHVK YNDLQARSLG CLTQQNPIRR FCVNIIKSPW FDRFIVLMVL
ANTLILSLVD YSEPWESGPN PTKLGNIIVA RANDIALLIF SAEAVVKIIA LGVTGPYSYS
LDNWNKLDAI VVLTGLASKI LESLERDSVV GLTQLRMLRI LRPLRTLHSL PGLKVLANSV
LSSLPALFNV TILLGFSYLV FAILGMDIWA GSYHGRCRLT EFPVQLNFNA SAAPINFTYP
NQTWIDTVVK DPAVYRCVDM ANDSPDWTPQ NCFWPLDPAD TVGLYCGSRE CSPGTFCGSN
YDVNGQPRFL DIFVNTTTPS TAPAFSIMTE PDFTPNLNFG LTSFDNVGSA MIIILQVVTA
SGWMVITQNT QDCLSSVLGG IYFNLALFIG MCFLLQLNMA VVYFEYQKAK EMQELVRLGS
IPPAFRRQAT MITRKESIDN FFKTQKFTEA KTLRRENSTH AIGRTAISLR KVLLSIALSK
WFQTMATCVT AVNVLLLCSD HYPSEPSFDH WSEVLNAVCL AYFIFEMTVK LVAGGARSYL
GDKFNLFDLL TIVAGIVEFF IDPPRFIDGT PGNTSPIATF RLIRALKFVR SWKSLNRLMV
AIMDAMSEIL NFLFFLFMFI YIYALLGMEL FATKFHFDGD SRPLPFNNTN PTATLRRTNF
DSIRQAVMAV FQVITYDEWP SVMYDGWLST GAIAPVYFIS IVVFGVWIIM SMFCAIMVDS
VMEGVGDVND DDARSLVPSL AVIRLKRAMR MVLAITKFRR NAIVPTSVRA SVKKLHTSRS
LGLFSYTNPI RKACVAAIVH PLWNKAMFGS IGVSCIFTAI DSPLQDTAVG VGLLVEIANK
LFAVLFAFEM VVTVVALGLV VGRRTYLRDP WRVLDFFIVI VSLLSWAIGN DAGGALSGLR
SLRSLRALRP LRVINKLPQL KVVVNTLFQC LPDIGRSLVF FFFMQLLFAV PGVIFFKGSL
NTCSISPYQY LDHPTFSPPP PWFPSNYSGN YTMAELQVVD IMTFPTNWSL LDPSIQALLA
STCNMTEASL AEQQFVPTSK QICTCFSPQT SWSPLVPQRF DNIAESMMSF FELTTFEGWT
NVANACIDAT GPDTQPLANH QPWFMLYWIV FMIVGAFFVT NMFIAVLCDA FMREKYGVMV
TDEQIDWVKD QRKVLSLSIT VHYDPPSSRW RRWCFYLVRH KKFEYAIISC ILLNMAGMTV
TYSSQPVWMA QALSLLSRVC LVVFAAEAAL KVAAYGPLYF GQGSNRFDFA VVLLTTVSEL
LPQNSSVSAG ATVFRIFRVG RALRLINKAK LMRSLFNTVV VSLPSVGNVM GLLMLLYYIF
AALGVQLFAK LNDGPEMVNS HQNFQTFWTA FQMLIGFSTG ENWDTFMWEA YNVGCPNSGC
ASWLIVPYFY AFTLIVGYIG LNLFSAIIVD AIGDDGKSPI TPEALEAFAA KWAEFDRLAT
GFIRIPELVV MLGQLPPPFG FKCVPGFTPR RIQKAIGDLR IPVYDRIWVH FKDVPRALVQ
RVLSQGSKSR FEEITELVQR LGIDNEFDLI WKRTHKKAEV LALAGREKTP VKLVVASRII
ITFLRKVNHH RERRRRRSTV IETIALES
//
