ID A0A024VKE6_PLAFA Unreviewed; 1491 AA.
AC A0A024VKE6;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=tRNA/rRNA methyltransferase SpoU type domain-containing protein {ECO:0000259|Pfam:PF00588};
GN ORFNames=PFFCH_03897 {ECO:0000313|EMBL:ETW28768.1};
OS Plasmodium falciparum FCH/4.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036724 {ECO:0000313|EMBL:ETW28768.1, ECO:0000313|Proteomes:UP000030656};
RN [1] {ECO:0000313|EMBL:ETW28768.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW28768.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW28768.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW28768.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005156}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI928022; ETW28768.1; -; Genomic_DNA.
DR EnsemblProtists; ETW28768; ETW28768; PFFCH_03897.
DR UniPathway; UPA00559; -.
DR Proteomes; UP000030656; Unassembled WGS sequence.
DR GO; GO:0090560; F:2-(3-amino-3-carboxypropyl)histidine synthase activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0016423; F:tRNA (guanine) methyltransferase activity; IEA:InterPro.
DR GO; GO:0017183; P:protein histidyl modification to diphthamide; IEA:UniProtKB-UniPathway.
DR GO; GO:0030488; P:tRNA methylation; IEA:InterPro.
DR CDD; cd18091; SpoU-like_TRM3-like; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR Gene3D; 3.40.50.11840; Diphthamide synthesis DPH1/DPH2 domain 1; 1.
DR Gene3D; 3.40.50.11860; Diphthamide synthesis DPH1/DPH2 domain 3; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR016435; DPH1/DPH2.
DR InterPro; IPR042263; DPH1/DPH2_1.
DR InterPro; IPR042265; DPH1/DPH2_3.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR045330; Trm3/TARBP1.
DR InterPro; IPR044748; Trm3/TARBP1_C.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR NCBIfam; TIGR00322; diphth2_R; 2.
DR PANTHER; PTHR12029:SF11; METHYLTRANSFERASE TARBP1-RELATED; 1.
DR PANTHER; PTHR12029; RNA METHYLTRANSFERASE; 1.
DR Pfam; PF01866; Diphthamide_syn; 2.
DR Pfam; PF00588; SpoU_methylase; 1.
DR SFLD; SFLDS00032; Radical_SAM_3-amino-3-carboxyp; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030656}.
FT DOMAIN 633..774
FT /note="tRNA/rRNA methyltransferase SpoU type"
FT /evidence="ECO:0000259|Pfam:PF00588"
FT REGION 890..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1491 AA; 176833 MW; 4F23C7DD3379C2DB CRC64;
MILYIYETLI IYILKKIDNK NIYHMNNKSP NIINSSNDNK SFFNIQQNKE KEKIPPLPSS
HGHNIQLRGL QALCMLSKYF KHLKKKKRKE IISYINIILI YDHLNNTRQY LEYFCLAISH
SSFVLMYPYL IKYLSHDNVN NQLTITSLII CAYLFLKSKF SYYSFEQLYI NSYAQICCTK
EKKKKKKSVL TKNGPILNKK ESKLKRRAQG KKVKHIINEL VKKNKNDING IVQGVKKMKN
MSTHKNDKKG YNDYVTNNNI VHNFDNKKYD NKKYDNKKGK DHNYNMIKVE MVRRKDSFKN
NDLKINEDKN GDICNISNEK KERRKDNIQN DYFYSEHIFK CLLKLLYGIV SLCSSHSAII
RSMAQFILYK FIKIKGTSHL NPFFSSLFSY IKYNKDCKRI RKKIKNQFNY WNVSFFDNIR
FLLPTENYSY NHFDEDRNYN NVNTFAHILY NNELVMSYTF LDKFKQIVQQ EMSFMIFNID
LEKEKQTDKN FKLNSEQNVS LNMINRIYEH NIRTQIERVH DKEGSSKNVY SDSTEETFMS
YDNSVDIKSD DVNKKSDSSN IADEHIPINY NEGNKKNITN ISSEINDDII ILENILEKNK
NNYQKKFDPI SNIIEIHNEF RKNYLNNKKK NDLIVIASLI DKLPNLAGLC RTCEIFNVKK
LLIDNINIIK DYQFQKISST ANKWMNIKEL KKSNIINYII KKKKKYSIIG LEQTHNSQKL
NHFVFPKKCI LILGDEKEGL PSSILMFLHH CIEIPGQGII RSLNVHVSAA ITIYEYELKL
LINIILNNNY KNVAIQLPDC MLKDSLCITN LLKNEFQKYN KEIIFNESIK NNGSINRNDS
ECSPYCCKEK KNGEDLHTNE KKKNNCNDNK MDDDKGNIKS SVHVDVVENN NNNNEHNNEH
NINHNNNNNN NNNNNKDKHV NLYILGDTTL NECCEDYVSA EHVEADFLVH YGISCQSFIT
PFIPSIYIFN KQNIEDNFFH NIKQYLKNEN VFKQNKTSII LCDASFAHVL PELVRCFFDK
IEKNNNICTD LKNEEKKEIN DSLSFYNYNN KVLYNVDDKM YVNKTFYEKG EDNYNECNIT
DLKNDNNRNN DDYYDNSEDD MIFTNIIVCL YRIANNINGK VCYGFFNNYV EFDIKDKIED
KYLFMCGRLV FKVFYNMKKE MIVYKIVEKK KEERQIYEEN GDDELINNKN MNLFIFSSDN
KNFINRCLLE YNNCNNIYIY DSKDIFIKDT RKIIDKVLLK RYSLIEKCKQ VNNVGILISN
VNLEKNKEIR ILINYILRKN KKKCFTVVTN KLNTAKLENF YDIEIYILLT CPENNLLELK
EFSKKIINPY EFFIAYNYIE WDGKYVFDFF ELLNISSIKK EYQAIHNNKY FLWNMDADFF
TIKNHHKDNK DNNDENVNVI IQQNNLVLEK YDHLIDTNLS ISVEDQKKFI TRFQEDSQMC
TYFLNILKEN NKREYKGVDI NYNTDHVPHI VKGLYGIAQK YDTDIKHLKE Q
//