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Database: UniProt
Entry: A0A024VKE6_PLAFA
LinkDB: A0A024VKE6_PLAFA
Original site: A0A024VKE6_PLAFA 
ID   A0A024VKE6_PLAFA        Unreviewed;      1491 AA.
AC   A0A024VKE6;
DT   09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=tRNA/rRNA methyltransferase SpoU type domain-containing protein {ECO:0000259|Pfam:PF00588};
GN   ORFNames=PFFCH_03897 {ECO:0000313|EMBL:ETW28768.1};
OS   Plasmodium falciparum FCH/4.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=1036724 {ECO:0000313|EMBL:ETW28768.1, ECO:0000313|Proteomes:UP000030656};
RN   [1] {ECO:0000313|EMBL:ETW28768.1, ECO:0000313|Proteomes:UP000030656}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FCH/4 {ECO:0000313|EMBL:ETW28768.1,
RC   ECO:0000313|Proteomes:UP000030656};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA   Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Annotation of Plasmodium falciparum FCH/4.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ETW28768.1, ECO:0000313|Proteomes:UP000030656}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FCH/4 {ECO:0000313|EMBL:ETW28768.1,
RC   ECO:0000313|Proteomes:UP000030656};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum FCH/4.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005156}.
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DR   EMBL; KI928022; ETW28768.1; -; Genomic_DNA.
DR   EnsemblProtists; ETW28768; ETW28768; PFFCH_03897.
DR   UniPathway; UPA00559; -.
DR   Proteomes; UP000030656; Unassembled WGS sequence.
DR   GO; GO:0090560; F:2-(3-amino-3-carboxypropyl)histidine synthase activity; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0016423; F:tRNA (guanine) methyltransferase activity; IEA:InterPro.
DR   GO; GO:0017183; P:protein histidyl modification to diphthamide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0030488; P:tRNA methylation; IEA:InterPro.
DR   CDD; cd18091; SpoU-like_TRM3-like; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   Gene3D; 3.40.50.11840; Diphthamide synthesis DPH1/DPH2 domain 1; 1.
DR   Gene3D; 3.40.50.11860; Diphthamide synthesis DPH1/DPH2 domain 3; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR016435; DPH1/DPH2.
DR   InterPro; IPR042263; DPH1/DPH2_1.
DR   InterPro; IPR042265; DPH1/DPH2_3.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR045330; Trm3/TARBP1.
DR   InterPro; IPR044748; Trm3/TARBP1_C.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   NCBIfam; TIGR00322; diphth2_R; 2.
DR   PANTHER; PTHR12029:SF11; METHYLTRANSFERASE TARBP1-RELATED; 1.
DR   PANTHER; PTHR12029; RNA METHYLTRANSFERASE; 1.
DR   Pfam; PF01866; Diphthamide_syn; 2.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   SFLD; SFLDS00032; Radical_SAM_3-amino-3-carboxyp; 1.
DR   SUPFAM; SSF75217; alpha/beta knot; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030656}.
FT   DOMAIN          633..774
FT                   /note="tRNA/rRNA methyltransferase SpoU type"
FT                   /evidence="ECO:0000259|Pfam:PF00588"
FT   REGION          890..916
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1491 AA;  176833 MW;  4F23C7DD3379C2DB CRC64;
     MILYIYETLI IYILKKIDNK NIYHMNNKSP NIINSSNDNK SFFNIQQNKE KEKIPPLPSS
     HGHNIQLRGL QALCMLSKYF KHLKKKKRKE IISYINIILI YDHLNNTRQY LEYFCLAISH
     SSFVLMYPYL IKYLSHDNVN NQLTITSLII CAYLFLKSKF SYYSFEQLYI NSYAQICCTK
     EKKKKKKSVL TKNGPILNKK ESKLKRRAQG KKVKHIINEL VKKNKNDING IVQGVKKMKN
     MSTHKNDKKG YNDYVTNNNI VHNFDNKKYD NKKYDNKKGK DHNYNMIKVE MVRRKDSFKN
     NDLKINEDKN GDICNISNEK KERRKDNIQN DYFYSEHIFK CLLKLLYGIV SLCSSHSAII
     RSMAQFILYK FIKIKGTSHL NPFFSSLFSY IKYNKDCKRI RKKIKNQFNY WNVSFFDNIR
     FLLPTENYSY NHFDEDRNYN NVNTFAHILY NNELVMSYTF LDKFKQIVQQ EMSFMIFNID
     LEKEKQTDKN FKLNSEQNVS LNMINRIYEH NIRTQIERVH DKEGSSKNVY SDSTEETFMS
     YDNSVDIKSD DVNKKSDSSN IADEHIPINY NEGNKKNITN ISSEINDDII ILENILEKNK
     NNYQKKFDPI SNIIEIHNEF RKNYLNNKKK NDLIVIASLI DKLPNLAGLC RTCEIFNVKK
     LLIDNINIIK DYQFQKISST ANKWMNIKEL KKSNIINYII KKKKKYSIIG LEQTHNSQKL
     NHFVFPKKCI LILGDEKEGL PSSILMFLHH CIEIPGQGII RSLNVHVSAA ITIYEYELKL
     LINIILNNNY KNVAIQLPDC MLKDSLCITN LLKNEFQKYN KEIIFNESIK NNGSINRNDS
     ECSPYCCKEK KNGEDLHTNE KKKNNCNDNK MDDDKGNIKS SVHVDVVENN NNNNEHNNEH
     NINHNNNNNN NNNNNKDKHV NLYILGDTTL NECCEDYVSA EHVEADFLVH YGISCQSFIT
     PFIPSIYIFN KQNIEDNFFH NIKQYLKNEN VFKQNKTSII LCDASFAHVL PELVRCFFDK
     IEKNNNICTD LKNEEKKEIN DSLSFYNYNN KVLYNVDDKM YVNKTFYEKG EDNYNECNIT
     DLKNDNNRNN DDYYDNSEDD MIFTNIIVCL YRIANNINGK VCYGFFNNYV EFDIKDKIED
     KYLFMCGRLV FKVFYNMKKE MIVYKIVEKK KEERQIYEEN GDDELINNKN MNLFIFSSDN
     KNFINRCLLE YNNCNNIYIY DSKDIFIKDT RKIIDKVLLK RYSLIEKCKQ VNNVGILISN
     VNLEKNKEIR ILINYILRKN KKKCFTVVTN KLNTAKLENF YDIEIYILLT CPENNLLELK
     EFSKKIINPY EFFIAYNYIE WDGKYVFDFF ELLNISSIKK EYQAIHNNKY FLWNMDADFF
     TIKNHHKDNK DNNDENVNVI IQQNNLVLEK YDHLIDTNLS ISVEDQKKFI TRFQEDSQMC
     TYFLNILKEN NKREYKGVDI NYNTDHVPHI VKGLYGIAQK YDTDIKHLKE Q
//
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