ID A0A024VRA4_PLAFA Unreviewed; 1272 AA.
AC A0A024VRA4;
DT 09-JUL-2014, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=CNNM transmembrane domain-containing protein {ECO:0000259|PROSITE:PS51846};
GN ORFNames=PFFCH_01713 {ECO:0000313|EMBL:ETW30833.1};
OS Plasmodium falciparum FCH/4.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036724 {ECO:0000313|EMBL:ETW30833.1, ECO:0000313|Proteomes:UP000030656};
RN [1] {ECO:0000313|EMBL:ETW30833.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW30833.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW30833.1, ECO:0000313|Proteomes:UP000030656}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FCH/4 {ECO:0000313|EMBL:ETW30833.1,
RC ECO:0000313|Proteomes:UP000030656};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum FCH/4.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI927883; ETW30833.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A024VRA4; -.
DR EnsemblProtists; ETW30833; ETW30833; PFFCH_01713.
DR Proteomes; UP000030656; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR002550; CNNM.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF59; UNEXTENDED PROTEIN; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU01193, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030656};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU01193,
KW ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|PROSITE-ProRule:PRU01193,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..184
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT REGION 405..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 996..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1137..1164
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1272 AA; 147246 MW; C714ABCA7CE85AA3 CRC64;
MQLWLLITCI VVCGILSSLF SGLSLGIMML DTLQLNLLIL VSEKNKKEIN NAKNARKILP
LRNNTNEILV TFITANVMVN SAFSLLLSEV TDGFTSFIIS TLIITIFGEI IPQSICSKHG
LAIGGFFAPL IYVLKFLLYL FAKPTSLLLD HFVGKNVLNT YDKKQLKALV DMHKSAANIL
HEDEAKILVS ALELSQYKIV HIMTDIDYVF GIDYNSVINY DSIKRLLRSG FSRIPVINRN
KAECIVGLIH IKDLINIWFG INKIIFDNRN KLIRNQNIKK NGKIQLFYKK SNTINKNQKD
DSLNIDVQGG YYYMKKKSQK IRIANKIFTF NGQKLYSHKI LNDKQNDISS SNKKQNHITL
SQEYLNVKKK FISNYQGIYS NEIYNINNNN KENHNIIQTD SRSSNNITNV INSDSTSYDD
GSNNEDVKIN IGGTSFTNNS SSSNNSSSNN SCSSITTKKK HTKIINSTLV QDIKGNNKKK
NIGNINNSLE NHPYNKLISN QKNKEQINKQ INTQNKIKNT MDASFIFKHN YYDIGPSDII
NPSKLRNKKK QDMKKAPRII TKNKKVNFVD YLSDNMMDTN DENSTISSCN EYIYTNIKSK
INFYDKNRNK IKTKQLAKLF NKKKKQITFR LWDGDKKKKI EKNNKESDHM SNNNNIENVD
NIENVDNIEN VENVDNIENV DNIENVENIE NVENIENVEN VDNNNNDEQH KDVQSGEEII
GLIDDDNINL HLKHNNSYYN YNDKDKDMNN KHNYVLNNHK QPGKDIYSSD NIKSDKTINI
KNIKTYDKKD PTIQKTKSKT KTNTNTNTNT KTKWQFSQSI MIKENLNKEK NMKEIYKDIK
NFISINEHKS IEIPLKYILK HIGRYIYGVD YNDSILSLLN FFKSASNHMV VVRKVIYNDN
EDPKYAHIGI ITLEDVIEIL LQEEISDEFD FKKIKTGSSI PSNFVWKNSD DSKKKMKSKI
RRRNHKVVFD EDNVKMIEGL DVHASQNKIS LTTTINNNNN NNNINNNNDD GGGGNSCDNN
KIQRSTDVTK LGISPSHKDV LQRAQTILKY KKDIMNFLKE SIYFKYIDPQ LLNQYIQRKK
IKTLYKGEIL LKDNTFLNYA IILIKGKVKN LSSCQSQNII QDKCFIGLEA LGPSNIIELF
NQTIEKRNSL IKNIEEEEEK KKKRRRFTFS RTRLTLKSFR KKETILKKKK KKKKTIATKK
IPNQVTKSNT HVIKKNINIL FRKWYTQHVY YNKNEYVAET TCEYMMIPKS DYMDMIIECY
CNNQVEEIIE AS
//
